LSI Challenge: Health

The aim of Research Ireland enterprise partnership scheme PhD scholarship project is to examine novel targeted therapy approaches for triple negative breast cancer. This project is in partnership with the Clinical Cancer Research Trust. Triple negative breast cancer is a form of the disease where the cancer cells do not have any of the characteristics which allow them to be easily destroyed, making for fewer treatment options. Larissa Bless is testing combinations of antibody drug conjugates with targeted DNA damage repair inhibitors and radiotherapy, using 2D and 3D bioprinted TNBC cell models. This project will also inform on the role the stromal microenvironment plays in ADC response.

Overall, we hope that this project can provide the pre-clinical rationale for more effective yet kinder treatments for TNBC patients.