Research interests

➢ Regulation of the vascular cytoskeletal architecture via haemodynamic forces -the role of cytoskeletal adaptor proteins. ➢ Nuclear actin dynamics. ➢ Mechano-transduction and the regulation of vascular cellular fate and function. ➢ The investigation of uPAR-integrin interactions on integrin state (affinity, avidity) and integrin-dependent signaling pathways. ➢ MicroRNAs, micromanagers of the vascular transcriptome (collaboration with Applied Biosystems). ➢ Intergin-microRNA-GTPase signalling nexus in the vasculature. ➢ Microparticles as biomarkers: In vitro studies and in vivo testing of adverse effects of biologics, devices and drugs. ➢ Stratification of clinical trials by molecular and cellular techniques, e.g. Pharmacogenomics. ➢ Development of molecular/cellular prognostics and diagnostics for cardiovascular disease. ➢ Exercise, diet and lifestyle on vascular health and competence. ➢ Cell biology of platelets and megakaryocytes. ➢ Cell adhesion and migration.