Janosch Heller
Dr.
Dr Janosch Heller is an Irish Research Council Laureate and Assistant Professor of Biomedical Sciences in the School of Biotechnology at Dublin City University. Additionally, Dr Heller is an Honorary Lecturer at University College London Queen Square Institute of Neurology, UK.
Dr Heller obtained a Diplom in Biology with a focus on Biochemistry and Genetics from the University of Cologne in Germany before moving to the UK in 2009. There, he completed a PhD in Clinical Neurosciences under the supervision of Prof James Fawcett and Prof Keith Martin at the University of Cambridge. His research focused on activating integrins as a therapeutic strategy in spinal cord injury and age-related macular degeneration.
Afterwards, Dr. Heller moved to the Queen Square Institute of Neurology at University College London, UK as a Research Associate to work with Prof Dmitri Rusakov. He was the first to establish single molecule localisation microscopy at the Institute and investigated the nano-environment of tripartite synapses.
In 2018, Janosch joined the Royal College of Surgeons in Ireland and the SFI Research Centre FutureNeuro as a Marie Skłodowska-Curie Fellow. His project AstroMiRimage aimed at deciphering microRNA control of local translation in astrocytic processes in epilepsy.
In 2020, Dr Heller joined the School of Biotechnology at DCU to start his research group focussing on astrocytes as therapeutic targets in neurological diseases.
Book Chapter
| Year | Publication | |
|---|---|---|
| 2020 | (2020) 'Multicolor Superresolution Microscopy: Revealing the Nano World of Astrocytes In Situ' In: Volume Microscopy. [DOI] | |
| 2019 | (2019) 'A Method to Visualize the Nanoscopic Morphology of Astrocytes In Vitro and In Situ' In: Methods in Molecular Biology. [DOI] | |
| 2014 | Kwok, J.C.F.;Heller, J.P.;Zhao, R.-R.;Fawcett, J.W.; (2014) 'Targeting inhibitory chondroitin sulphate proteoglycans to promote plasticity after injury' In: Methods in Molecular Biology. [DOI] |
Peer Reviewed Journal
| Year | Publication | |
|---|---|---|
| 2021 | Michaluk P;Heller JP;Rusakov DA; (2021) 'Rapid recycling of glutamate transporters on the astroglial surface'. eLife, 10 . [DOI] | |
| 2020 | (2020) 'Imaging tripartite synapses using super-resolution microscopy'. Methods, . [DOI] | |
| 2020 | (2020) 'A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy'. Proceedings Of The National Academy Of Sciences, . [DOI] | |
| 2020 | Janosch P Heller;Tristan G Heintz;Jessica CF Kwok;Keith R Martin;James W Fawcett; (2020) 'Immunochemical analysis of the integrin expression in retinal pigment epithelial cells'. . [DOI] | |
| 2020 | Piotr Michaluk;Janosch Heller;Dmitri A. Rusakov; (2020) 'Rapid recycling of glutamate transporters on the astroglial surface'. . [DOI] | |
| 2020 | Henneberger C;Bard L;Panatier A;Reynolds JP;Kopach O;Medvedev NI;Minge D;Herde MK;Anders S;Kraev I;Heller JP;Rama S;Zheng K;Jensen TP;Sanchez-Romero I;Jackson CJ;Janovjak H;Ottersen OP;Nagelhus EA;Oliet SHR;Stewart MG;Nägerl UV;Rusakov DA; (2020) 'LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia'. Neuron, 108 (5). [DOI] | |
| 2019 | (2019) 'Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons'. . [DOI] | |
| 2019 | Naila Haq;Christoph Schmidt-Hieber;Fernando J. Sialana;Lorenza Ciani;Janosch P. Heller;Michelle Stewart;Liz Bentley;Sara Wells;Richard J. Rodenburg;Patrick M. Nolan;Elizabeth Forsythe;Michael C. Wu;Gert Lubec;P. Salinas;Michael Häusser;Philip L. Beales;Sofia Christou-Savina; (2019) 'Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons'. PLoS Biology, . [DOI] | |
| 2018 | (2018) 'LTP induction drives remodeling of astroglia to boost glutamate escape from synapses: Supplementary Figures'. . [DOI] | |
| 2018 | Andreas Lieb;Yichen Qiu;Christine L. Dixon;Janosch P. Heller;Matthew C. Walker;Stephanie Schorge;Dimitri M. Kullmann; (2018) 'Biochemical autoregulatory gene therapy for focal epilepsy'. Nature Medicine, . [DOI] | |
| 2017 | Janosch P. Heller;Piotr Michaluk;Kohtaroh Sugao;Dmitri A. Rusakov; (2017) 'Probing nano-organization of astroglia with multi-color super-resolution microscopy'. Neuroscience Research, . [DOI] | |
| 2017 | (2017) 'Exploring Nanoscale Organisation of Synapses with Super-Resolution Microscopy'. Opera Medica Et Physiologica, . [DOI] | |
| 2017 | Heller, J.P.;Rusakov, D.A.; (2017) 'The nanoworld of the tripartite synapse: Insights from super-resolution microscopy'. Frontiers in Cellular Neuroscience, . [DOI] | |
| 2015 | Heller, J.P.;Kwok, J.C.F.;Vecino, E.;Martin, K.R.;Fawcett, J.W.; (2015) 'A method for the isolation and culture of adult rat retinal pigment epithelial (RPE) cells to study retinal diseases'. Frontiers in Cellular Neuroscience, . [DOI] | |
| 2015 | Vecino, E.;Heller, J.P.;Veiga-Crespo, P.;Martin, K.R.;Fawcett, J.W.; (2015) 'Influence of extracellular matrix components on the expression of integrins and regeneration of adult retinal ganglion cells'. PLoS ONE, . [DOI] | |
| 2015 | Heller, J.P.;Rusakov, D.A.; (2015) 'Morphological plasticity of astroglia: Understanding synaptic microenvironment'. Glia, . [DOI] | |
| 2015 | White, A.J.R.;Heller, J.P.;Leung, J.;Tassoni, A.;Martin, K.R.; (2015) 'Retinal ganglion cell neuroprotection by an angiotensin II blocker in an ex vivo retinal explant model'. JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, . [DOI] | |
| 2015 | (2015) 'Full length talin stimulates integrin activation and axon regeneration'. MOLECULAR AND CELLULAR NEUROSCIENCE, . [DOI] | |
| 2014 | Heintz, T.G.;Heller, J.P.;Zhao, R.;Caceres, A.;Eva, R.;Fawcett, J.W.; (2014) 'Kinesin KIF4A transports integrin β1 in developing axons of cortical neurons'. MOLECULAR AND CELLULAR NEUROSCIENCE, . [DOI] | |
| 2014 | (2014) 'Enhancing RPE Cell-Based Therapy Outcomes for AMD: The Role of Bruch's Membrane'. Translational Vision Science & Technology, . [DOI] | |
| 2014 | Johnson, T.V.;Dekorver, N.W.;Levasseur, V.A.;Osborne, A.;Tassoni, A.;Lorber, B.;Heller, J.P.;Villasmil, R.;Bull, N.D.;Martin, K.R.;Tomarev, S.I.; (2014) 'Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome'. Brain, . [DOI] | |
| 2011 | Kwok, J.C.F.;Tan, C.L.;Wang, D.;Heller, J.;Fawcett, J.W.; (2011) 'Chondroitin sulfates in axon regeneration and plasticity'. Trends in Glycoscience and Glycotechnology, . [DOI] | |
| 2009 | Calamai, M.;Specht, C.G.;Heller, J.;Alcor, D.;Machado, P.;Vannier, C.;Triller, A.; (2009) 'Gephyrin oligomerization controls GlyR mobility and synaptic clustering'. Neuroscience, . [DOI] | |
| 2021 | Aleksejenko, N;Heller, JP (2021) 'Super-resolution imaging to reveal the nanostructure of tripartite synapses'. Neuronal signaling, 5 (4). [DOI] |
Certain data included herein are derived from the © Web of Science (2023) of Clarivate. All rights reserved.
Employment
Reviews
Research Interests
Dr. Heller’s current research interests are focused on manipulating astrocyte control of waste clearing in the brain. Specifically, Dr. Heller’s laboratory combines molecular and biochemical approaches together with state-of-the-art bioimaging (super-resolution microscopy) to understand how specialised glia cells change in disease and how these cells can be targeted as novel therapeutic intervention to treat neurological and neuropsychiatric diseases.