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Paula Meleady

Assoc. Prof

Contact Details


X211, School of Biotechnology
T:Ext. 5406

E:Paula.Meleady@dcu.ie
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1989-1993: BSc (Hons) Biotechnology, Dublin City University 1993-1997: Ph.D, National Cell and Tissue Culture Centre (NCTCC), DCU Oct 1997-May 2001: Post-doctoral Research Scientist, NCTCC, DCU June 2001-present: Senior Research Scientist, NICB, DCU October 2007-present: Programme Leader, Proteomics Core Facility, NICB, DCU. October 2015 - present; Associate Director NICB. March 2021 - Assistant Professor, School of Biotechnology, DCU. October 2023 - Associate Professor, School of Biotechnology, DCU.

Book Chapter

Year Publication
2023 Meleady, P. (2023) 'Two-Dimensional Gel Electrophoresis and 2D-DIGE' In: Methods in Molecular Biology. [Link] [DOI]
2017 Henry, M.; Meleady, P. (2017) 'Clinical proteomics: Liquid chromatography–Mass spectrometry (LC–MS) purification systems' In: Methods in Molecular Biology. [Link] [DOI]
2017 Henry, M.; Coleman, O.; Prashant, ; Clynes, M.; Meleady, P. (2017) 'Phosphopeptide enrichment and LC-MS/MS analysis to study the phosphoproteome of recombinant chinese hamster ovary cells' In: Methods in Molecular Biology. [Link] [DOI]
2017 Coleman, O.; Henry, M.; Clynes, M.; Meleady, P. (2017) 'Filter-aided sample preparation (FASP) for improved proteome analysis of recombinant chinese hamster ovary cells' In: Methods in Molecular Biology. [Link] [DOI]
2017 Henry, M; Meleady, P (2017) 'Clinical Proteomics: Liquid Chromatography-Mass Spectrometry (LC-MS) Purification Systems' In: PROTEIN CHROMATOGRAPHY: METHODS AND PROTOCOLS, 2ND EDITION. TOTOWA : HUMANA PRESS INC. [DOI]
2012 Colin Clarke, Niall Barron, Mark Gallagher, Michael Henry, Paula Meleady, Martin Clynes (2012) 'Target prediction algorithms and bioinformatics resources for miRNA studies' In: MicroRNAs as Tools in Biopharmaceutical Production. Netherlands : Springer.
2012 Clarke, C.; Barron, N.; Gallagher, M.; Henry, M.; Meleady, P.; Clynes, M. (2012) 'Target prediction algorithms and bioinformatics resources for miRNA studies' In: MicroRNAs as Tools in Biopharmaceutical Production. [Link] [DOI]
2011 Dowling P, Clynes M and Meleady P (2011) 'Sample preparation techniques for cancer proteomics' In: Sample Preparation in Biological Mass Spectrometry. USA : Springer.
2011 Henry, M; Meleady, P (2011) 'Clinical Proteomics: Liquid Chromatography-Mass Spectrometry Purification Systems' In: PROTEIN CHROMATOGRAPHY: METHODS AND PROTOCOLS. TOTOWA : HUMANA PRESS INC. [DOI]
2011 Henry M and Meleady P. (2011) 'Clinical proteomics –Liquid Chromatography-Mass Spectrometry (LC/MS) purification systems' In: Walls D and Loughran S(Eds.). Protein Chromatography: Methods and Protocols. Methods in Molecular Biology. : 0.
2011 Meleady P (2011) '2D electrophoresis and mass spectrometry identification and analysis of proteins' In: Gene Expression Profiling: Methods and Protocols. USA : Humana Press.
2006 Meleady, P, O'Connor R (2006) 'General Procedures for Cell Culture' In: Celis J(Eds.). Cell Biology, A Laboratory Handbook. : Elsevier Academic Press.
2006 Meleady, P.; O'Connor, R. (2006) 'General procedures for cell culture' In: Cell Biology, Four-Volume Set. [Link] [DOI]
2005 Meleady, P.; O'Connor, R. (2005) 'General procedures for cell culture' In: Cell Biology: A Laboratory Handbook. [Link] [DOI]
1998 Meleady, P., O'Sullivan, F., McBride, S. and Clynes, M. (1998) 'Isolation, cultivation and differentiation of lung type II epithelial cells. In: Animal Cell Culture Techniques' In: Animal Cell Culture Techniques. : 0.
1998 Keenan, J., Meleady, P. and Clynes, M. (1998) 'Serum-free media' In: Animal Cell Culture Techniques. : 0.
1998 O'Sullivan, F., Meleady, P., McBride, S. and Clynes, M. (1998) 'Primary culture' In: Animal Cell Culture Techniques. : 0.

Edited Book

Year Publication
2017 Meleady P (Ed.). (2017) Heterologous Protein Production in CHO cells. USA: Humana Press, Springer,

Peer Reviewed Journal

Year Publication
2023 Di Luca, A; Bennato, F; Ianni, A; Grotta, L; Henry, M; Meleady, P; Martino, G (2023) 'Comparative Label-Free Liquid Chromatography-Mass Spectrometry Milk Proteomic Profiles Highlight Putative Differences between the Autochthon Teramana and Saanen Goat Breeds'. Animals : An Open Access Journal From Mdpi, 13 (14). [DOI]
2023 Soliman, MG; Trinh, DN; Ravagli, C; Meleady, P; Henry, M; Movia, D; Doumett, S; Cappiello, L; Prina-Mello, A; Baldi, G; Monopoli, MP (2023) 'Development of a fast and simple method for the isolation of superparamagnetic iron oxide nanoparticles protein corona from protein-rich matrices'. Journal of Colloid and Interface Science, 659 . [DOI]
2023 Ryan, D.; Sideri, C.K.; Henry, M.; Efeoglu, E.; Meleady, P. (2023) 'Label-free quantitative proteomics analysis of producer and non-producer Chinese Hamsters Ovary (CHO) cells under ER stress conditions'. Current Research in Biotechnology, 6 . [Link] [DOI]
2023 Di Luca, A; Ianni, A; Bennato, F; Martino, C; Henry, M; Meleady, P; Martino, G (2023) 'Comparative Proteomics Analysis of Pig Muscle Exudate through Label-Free Liquid Chromatography-Mass Spectrometry'. Animals : An Open Access Journal From Mdpi, 13 (9). [DOI]
2023 Murphy, S; Schmitt-John, T; Dowling, P; Henry, M; Meleady, P; Swandulla, D; Ohlendieck, K (2023) 'Proteomic profiling of the brain from the wobbler mouse model of amyotrophic lateral sclerosis reveals elevated levels of the astrogliosis marker glial fibrillary acidic protein'. European Journal Of Translational Myology, 33 (3). [DOI]
2023 Henry, M; Meleady, P (2023) 'Clinical Proteomics: Liquid Chromatography-Mass Spectrometry (LC-MS) Purification Systems'. Methods in molecular biology (Clifton, N.J.), 2699 . [DOI]
2023 Dunphy, K; Bazou, D; Henry, M; Meleady, P; Miettinen, JJ; Heckman, CA; Dowling, P; O'Gorman, P (2023) 'Proteomic and Metabolomic Analysis of Bone Marrow and Plasma from Patients with Extramedullary Multiple Myeloma Identifies Distinct Protein and Metabolite Signatures'. Cancers, 15 (15). [DOI]
2023 Dowling, P; Zweyer, M; Sabir, H; Henry, M; Meleady, P; Swandulla, D; Ohlendieck, K (2023) 'Mass spectrometry-based proteomic characterization of the middle-aged mouse brain for animal model research of neuromuscular diseases'. European Journal Of Translational Myology, 33 (3). [DOI]
2022 O'Neill, F; Allen-Coyle, TJ; Roche, S; Meiller, J; Conlon, NT; Swan, N; Straubinger, RM; Geoghegan, J; Straubinger, NL; Conlon, K; McDermott, R; O'Sullivan, F; Henry, M; Meleady, P; McVey, G; O'Connor, R; Moriarty, M; Clynes, M (2022) 'Alteration in Levels of Specific miRNAs and Their Potential Protein Targets between Human Pancreatic Cancer Samples, Adjacent Normal Tissue, and Xenografts Derived from These Tumors'. Life (Basel, Switzerland), 13 (3). [DOI]
2022 Bookey, N; Drago, P; Leung, KY; Hughes, L; MacCooey, A; Ozaki, M; Henry, M; De Castro, SCP; Doykov, I; Heywood, WE; Mills, K; Murphy, MM; Cavallé-Busquets, P; Campbell, S; Burtenshaw, D; Meleady, P; Chill, PA; Greene, NDE; Parle-McDermott, A (2022) 'The Differential Translation Capabilities of the Human DHFR2 Gene Indicates a Developmental and Tissue-Specific Endogenous Protein of Low Abundance'. MOLECULAR & CELLULAR PROTEOMICS, 23 (3). [DOI]
2022 Trinh, DN; Radlinskaite, M; Cheeseman, J; Kuhnle, G; Osborn, HMI; Meleady, P; Spencer, DIR; Monopoli, MP (2022) 'Biomolecular Corona Stability in Association with Plasma Cholesterol Level'. Nanomaterials (Basel, Switzerland), 12 (15). [DOI]
2022 Smith, H; Grant, S; Meleady, P; Henry, M; O'Gorman, D; Clynes, M; Murphy, R (2022) 'Yeast Mannan-Rich Fraction Modulates Endogenous Reactive Oxygen Species Generation and Antibiotic Sensitivity in Resistant E. coli'. International Journal of Molecular Sciences, 24 (1). [DOI]
2022 Di Luca, A.; Ianni, A.; Bennato, F.; Henry, M.; Meleady, P.; Martino, G. (2022) 'A Label-Free Quantitative Analysis for the Search of Proteomic Differences between Goat Breeds'. Animals, 12 . [Link] [DOI]
2022 Gargan, S.; Dowling, P.; Zweyer, M.; Henry, M.; Meleady, P.; Swandulla, D.; Ohlendieck, K. (2022) 'Proteomic Identification of Markers of Membrane Repair, Regeneration and Fibrosis in the Aged and Dystrophic Diaphragm'. Life, 12 . [Link] [DOI]
2022 Efeoglu, E.; Henry, M.; Clynes, M.; Meleady, P. (2022) 'Label-Free Quantitative Proteomics Analysis of Adriamycin Selected Multidrug Resistant Human Lung Cancer Cells'. Biomolecules, 12 . [Link] [DOI]
2022 Di Luca, A; Ianni, A; Henry, M; Martino, C; Meleady, P; Martino, G (2022) 'Label-free quantitative proteomics and stress responses in pigs-The case of short or long road transportation'. PLoS ONE, 17 (11). [DOI]
2022 Ramos, T; Parekh, M; Meleady, P; O'Sullivan, F; Stewart, RMK; Kaye, SB; Hamill, K; Ahmad, S (2022) 'Specific decellularized extracellular matrix promotes the plasticity of human ocular surface epithelial cells'. Frontiers in medicine, 9 . [DOI]
2022 Meleady, P (2022) 'Two-Dimensional Gel Electrophoresis and 2D-DIGE'. Methods in molecular biology (Clifton, N.J.), 2596 . [DOI]
2021 Parle-McDermott, A; Bookey, N; Meleady, P; Drago, P (2021) 'Methods to Study Translated Pseudogenes: Recombinant Expression and Complementation, Targeted Proteomics, and RNA Profiling'. Methods in molecular biology (Clifton, N.J.), 2324 . [DOI]
2020 O'Brien, M.E.; Fee, L.; Browne, N.; Carroll, T.P.; Meleady, P.; Henry, M.; McQuillan, K.; Murphy, M.P.; Logan, M.; McCarthy, C.; McElvaney, O.J.; Reeves, E.P.; McElvaney, N.G. (2020) 'Activation of complement component 3 is associated with airways disease and pulmonary emphysema in alpha-1 antitrypsin deficiency'. Thorax, 75 . [Link] [DOI]
2020 Murphy, M.P.; McEnery, T.; McQuillan, K.; McElvaney, O.F.; McElvaney, O.J.; Landers, S.; Coleman, O.; Bussayajirapong, A.; Hawkins, P.; Henry, M.; Meleady, P.; Reeves, E.P.; McElvaney, N.G. (2020) 'α1 Antitrypsin therapy modulates the neutrophil membrane proteome and secretome'. European Respiratory Journal, 55 . [Link] [DOI]
2020 O'Doherty, C; O'Sullivan, F; Henry, M; Meleady, P; Clynes, M; Horgan, K; Keenan, J; Murphy, R (2020) 'LC-MS proteomic profiling of Caco-2 human intestinal cells exposed to the copper-chelating agent, triethylenetetramine: A preliminary study'. Biochemical and Biophysical Research Communications, 524 (4). [DOI]
2019 O'Doherty, C; Keenan, J; Henry, M; Meleady, P; Sinkunaite, I; Clynes, M; O'Sullivan, F; Horgan, K; Murphy, R (2019) 'Characterisation and proteomic profiling of continuously exposed Cu-resistant variants of the Caco-2 cell line'. Toxicology in vitro : an international journal published in association with BIBRA, 65 . [DOI]
2019 Dowling, P; Zweyer, M; Raucamp, M; Henry, M; Meleady, P; Swandulla, D; Ohlendieck, K (2019) 'Proteomic and cell biological profiling of the renal phenotype of the mdx-4cv mouse model of Duchenne muscular dystrophy'. European Journal of Cell Biology, 99 (1). [DOI]
2019 Dowling, P; Zweyer, M; Raucamp, M; Henry, M; Meleady, P; Swandulla, D; Ohlendieck, K (2019) 'Dataset on the mass spectrometry-based proteomic profiling of the kidney from wild type and the dystrophic mdx-4cv mouse model of X-linked muscular dystrophy'. Data In Brief, 28 . [DOI]
2019 Reeves, E.P.; Dunlea, D.M.; McQuillan, K.; O’Dwyer, C.A.; Carroll, T.P.; Saldova, R.; Akepati, P.R.; Wormald, M.R.; McElvaney, O.J.; Shutchaidat, V.; Henry, M.; Meleady, P.; Keenan, J.; Liberti, D.C.; Kotton, D.N.; Rudd, P.M.; Wilson, A.A.; McElvaney, N.G. (2019) 'Circulating truncated alpha-1 antitrypsin glycoprotein in patient plasma retains anti-inflammatory capacity'. Journal of Immunology, 202 . [Link] [DOI]
2019 Murphy, S.; Zweyer, M.; Henry, M.; Meleady, P.; Mundegar, R.R.; Swandulla, D.; Ohlendieck, K. (2019) 'Proteomic analysis of the sarcolemma-enriched fraction from dystrophic mdx-4cv skeletal muscle'. Journal of Proteomics, 191 . [Link] [DOI]
2019 Coleman, O.; Suda, S.; Meiller, J.; Henry, M.; Riedl, M.; Barron, N.; Clynes, M.; Meleady, P. (2019) 'Increased growth rate and productivity following stable depletion of miR-7 in a mAb producing CHO cell line causes an increase in proteins associated with the Akt pathway and ribosome biogenesis'. Journal of Proteomics, 195 . [Link] [DOI]
2019 Clarke, C.; Gallagher, C.; Kelly, R.M.; Henry, M.; Meleady, P.; Frye, C.C.; Osborne, M.D.; Brady, C.P.; Barron, N.; Clynes, M. (2019) 'Transcriptomic analysis of IgG4 Fc-fusion protein degradation in a panel of clonally-derived CHO cell lines using RNASeq'. Biotechnology and Bioengineering, 116 . [Link] [DOI]
2019 Ramasamy P; Larkin AM; Linge A; Tiernan D; McAree F; Horgan N; Moriarty P; Beatty S; Murphy CC; Clynes M; Kennedy S; Meleady P; (2019) 'PRDX3 is associated with metastasis and poor survival in uveal melanoma'. Journal of Clinical Pathology, . [DOI]
2019 Li, S; Cha, SW; Heffner, K; Hizal, DB; Bowen, MA; Chaerkady, R; Cole, RN; Tejwani, V; Kaushik, P; Henry, M; Meleady, P; Sharfstein, ST; Betenbaugh, MJ; Bafna, V; Lewis, NE (2019) 'Proteogenomic Annotation of Chinese Hamsters Reveals Extensive Novel Translation Events and Endogenous Retroviral Elements'. Journal of Proteome Research, 18 (6). [DOI]
2018 Kelly, PS; Dorival-García, N; Paré, S; Carillo, S; Ta, C; Alarcon Miguez, A; Coleman, O; Harper, E; Shannon, M; Henry, M; Connolly, L; Clynes, M; Meleady, P; Bones, J; Barron, N (2018) 'Improvements in single-use bioreactor film material composition leads to robust and reliable Chinese hamster ovary cell performance'. Biotechnology Progress, 35 (4). [DOI]
2018 Murphy, S; Zweyer, M; Raucamp, M; Henry, M; Meleady, P; Swandulla, D; Ohlendieck, K (2018) 'Proteomic profiling of the mouse diaphragm and refined mass spectrometric analysis of the dystrophic phenotype'. Journal of Muscle Research and Cell Motility, 40 (1). [DOI]
2018 Murphy, S; Henry, M; Meleady, P; Ohlendieck, K (2018) 'Utilization of dried and long-term stored polyacrylamide gels for the advanced proteomic profiling of mitochondrial contact sites from rat liver'. Biology methods & protocols, 3 (1). [DOI]
2018 Henry, M; Gallagher, C; Kelly, RM; Frye, CC; Osborne, MD; Brady, CP; Barron, N; Clynes, M; Meleady, P (2018) 'Clonal variation in productivity and proteolytic clipping of an Fc-fusion protein in CHO cells: Proteomic analysis suggests a role for defective protein folding and the UPR'. Journal of Biotechnology, 281 :21-30. [DOI]
2018 Trappe, A.; Füssl, F.; Carillo, S.; Zaborowska, I.; Meleady, P.; Bones, J. (2018) 'Rapid charge variant analysis of monoclonal antibodies to support lead candidate biopharmaceutical development'. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1095 . [Link] [DOI]
2018 Henry, M.; Gallagher, C.; Kelly, R.M.; Frye, C.C.; Osborne, M.D.; Brady, C.P.; Barron, N.; Clynes, M.; Meleady, P. (2018) 'Clonal variation in productivity and proteolytic clipping of an Fc-fusion protein in CHO cells: Proteomic analysis suggests a role for defective protein folding and the UPR'. Journal of Biotechnology, 281 . [Link] [DOI]
2018 Murphy, S; Zweyer, M; Henry, M; Meleady, P; Mundegar, RR; Swandulla, D; Ohlendieck, K (2018) 'Proteomic profiling of liver tissue from the mdx-4cv mouse model of Duchenne muscular dystrophy'. Clinical Proteomics, 15 . [DOI]
2018 Kaushik, P; Henry, M; Clynes, M; Meleady, P (2018) 'The Expression Pattern of the Phosphoproteome Is Significantly Changed During the Growth Phases of Recombinant CHO Cell Culture'. Biotechnology journal, 13 (10). [DOI]
2018 Keenan, J; O'Sullivan, F; Henry, M; Breen, L; Doolan, P; Sinkunaite, I; Meleady, P; Clynes, M; Horgan, K; Murphy, R (2018) 'Acute exposure to organic and inorganic sources of copper: Differential response in intestinal cell lines'. FOOD SCIENCE & NUTRITION, 6 (8). [DOI]
2018 Coleman, O; Henry, M; O'Neill, F; Roche, S; Swan, N; Boyle, L; Murphy, J; Meiller, J; Conlon, NT; Geoghegan, J; Conlon, KC; Lynch, V; Straubinger, NL; Straubinger, RM; McVey, G; Moriarty, M; Meleady, P; Clynes, M (2018) 'A Comparative Quantitative LC-MS/MS Profiling Analysis of Human Pancreatic Adenocarcinoma, Adjacent-Normal Tissue, and Patient-Derived Tumour Xenografts'. Proteomes, 6 (4). [DOI]
2018 Costello, A; Coleman, O; Lao, NT; Henry, M; Meleady, P; Barron, N; Clynes, M (2018) 'Depletion of endogenous miRNA-378-3p increases peak cell density of CHO DP12 cells and is correlated with elevated levels of ubiquitin carboxyl-terminal hydrolase 14'. Journal of Biotechnology, 288 . [DOI]
2018 Coleman, O; Costello, A; Henry, M; Lao, NT; Barron, N; Clynes, M; Meleady, P (2018) 'A proteomic profiling dataset of recombinant Chinese hamster ovary cells showing enhanced cellular growth following miR-378 depletion'. Data In Brief, 21 . [DOI]
2018 Hu, S.; Musante, L.; Tataruch, D.; Xu, X.; Kretz, O.; Henry, M.; Meleady, P.; Luo, H.; Zou, H.; Jiang, Y.; Holthofer, H. (2018) 'Purification and Identification of Membrane Proteins from Urinary Extracellular Vesicles using Triton X-114 Phase Partitioning'. Journal of Proteome Research, 17 . [Link] [DOI]
2017 Lopes-Rodrigues, V; Di Luca, A; Mleczko, J; Meleady, P; Henry, M; Pesic, M; Cabrera, D; van Liempd, S; Lima, RT; O' Connor, R; Falcon-Perez, JM; Vasconcelos, MH (2017) 'Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles'. Scientific Reports, 7 . [DOI]
2017 Costello, Alan; Lao, Nga; Clynes, Martin; Barron, Niall (2017) 'Conditional Knockdown of Endogenous MicroRNAs in CHO Cells Using TET-ON-SanDI Sponge Vectors'. RNA INTERFERENCE: FROM BIOLOGY TO CLINICAL APPLICATIONS, 1603 . [DOI]
2017 Henry, M; Power, M; Kaushik, P; Coleman, O; Clynes, M; Meleady, P (2017) 'Differential Phosphoproteomic Analysis of Recombinant Chinese Hamster Ovary Cells Following Temperature Shift'. Journal of Proteome Research, 16 :2339-2358. [DOI]
2017 O' Sullivan, F; Keenan, J; Aherne, S; O' Neill, F; Clarke, C; Henry, M; Meleady, P; Breen, L; Barron, N; Clynes, M; Horgan, K; Doolan, P; Murphy, R (2017) 'Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine'. World Journal of Gastroenterology, 23 :7369-7386. [DOI]
2017 O' Sullivan, F; Keenan, J; Aherne, S; O' Neill, F; Clarke, C; Henry, M; Meleady, P; Breen, L; Barron, N; Clynes, M; Horgan, K; Doolan, P; Murphy, R (2017) 'Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine'. World Journal of Gastroenterology, 23 :7369-7386. [DOI]
2017 Ting, KR; Henry, M; Meiller, J; Larkin, A; Clynes, M; Meleady, P; Bazou, D; Dowling, P; O' Gorman, P (2017) 'Novel panel of protein biomarkers to predict response to bortezomib-containing induction regimens in multiple myeloma patients'. BBA Clinical, 8 :28-34. [DOI]
2017 Murphy, S; Brinkmeier, H; Krautwald, M; Henry, M; Meleady, P; Ohlendieck, K (2017) 'Proteomic profiling of the dystrophin complex and membrane fraction from dystrophic mdx muscle reveals decreases in the cytolinker desmoglein and increases in the extracellular matrix stabilizers biglycan and fibronectin'. Journal of Muscle Research and Cell Motility, 38 (2). [DOI]
2017 Henry, M; Power, M; Kaushik, P; Coleman, O; Clynes, M; Meleady, P (2017) 'Differential Phosphoproteomic Analysis of Recombinant Chinese Hamster Ovary Cells Following Temperature Shift'. Journal of Proteome Research, 16 (7). [DOI]
2017 White, M.M.; Geraghty, P.; Hayes, E.; Cox, S.; Leitch, W.; Alfawaz, B.; Lavelle, G.M.; McElvaney, O.J.; Flannery, R.; Keenan, J.; Meleady, P.; Henry, M.; Clynes, M.; Gunaratnam, C.; McElvaney, N.G.; Reeves, E.P. (2017) 'Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease'. Ebiomedicine, 23 . [Link] [DOI]
2017 Lopes-Rodrigues, V.; Di Luca, A.; Mleczko, J.; Meleady, P.; Henry, M.; Pesic, M.; Cabrera, D.; Van Liempd, S.; Lima, R.T.; O'Connor, R.; Falcon-Perez, J.M.; Vasconcelos, M.H. (2017) 'Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles'. Scientific Reports, 7 . [Link] [DOI]
2017 Murphy, S; Brinkmeier, H; Krautwald, M; Henry, M; Meleady, P; Ohlendieck, K (2017) 'Proteomic profiling of the dystrophin complex and membrane fraction from dystrophic mdx muscle reveals decreases in the cytolinker desmoglein and increases in the extracellular matrix stabilizers biglycan and fibronectin'. Journal of Muscle Research and Cell Motility, 38 :251-268. [DOI]
2017 Musante, L; Tataruch-Weinert, D; Kerjaschki, D; Henry, M; Meleady, P; Holthofer, H (2017) 'Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment'. Journal Of Extracellular Vesicles, 6 . [DOI]
2017 Ting, KR; Henry, M; Meiller, J; Larkin, A; Clynes, M; Meleady, P; Bazou, D; Dowling, P; O' Gorman, P (2017) 'Novel panel of protein biomarkers to predict response to bortezomib-containing induction regimens in multiple myeloma patients'. BBA Clinical, 8 :28-34. [DOI]
2017 White, MM; Geraghty, P; Hayes, E; Cox, S; Leitch, W; Alfawaz, B; Lavelle, GM; McElvaney, OJ; Flannery, R; Keenan, J; Meleady, P; Henry, M; Clynes, M; Gunaratnam, C; McElvaney, NG; Reeves, EP (2017) 'Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease'. Ebiomedicine, 23 :173-184. [DOI]
2017 O' Sullivan, F; Keenan, J; Aherne, S; O' Neill, F; Clarke, C; Henry, M; Meleady, P; Breen, L; Barron, N; Clynes, M; Horgan, K; Doolan, P; Murphy, R (2017) 'Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine'. World Journal of Gastroenterology, 23 :7369-7386. [DOI]
2017 McCarthy C; Dunlea DM; Saldova R; Henry M; Meleady P; McElvaney OJ; Marsh B; Rudd PM; Reeves EP; McElvaney NG; (2017) 'Glycosylation Repurposes Alpha-1 Antitrypsin for Resolution of Community-acquired-pneumonia'. American Journal of Respiratory and Critical Care Medicine, . [DOI]
2017 White, MM; Geraghty, P; Hayes, E; Cox, S; Leitch, W; Alfawaz, B; Lavelle, GM; McElvaney, OJ; Flannery, R; Keenan, J; Meleady, P; Henry, M; Clynes, M; Gunaratnam, C; McElvaney, NG; Reeves, EP (2017) 'Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease'. Ebiomedicine, 23 :173-184. [DOI]
2017 O'Sullivan, F; Keenan, J; Aherne, S; O'Neill, F; Clarke, C; Henry, M; Meleady, P; Breen, L; Barron, N; Clynes, M; Horgan, K; Doolan, P; Murphy, R (2017) 'Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine'. World Journal of Gastroenterology, 23 :7369-7386. [DOI]
2017 O'Sullivan, F; Keenan, J; Aherne, S; O'Neill, F; Clarke, C; Henry, M; Meleady, P; Breen, L; Barron, N; Clynes, M; Horgan, K; Doolan, P; Murphy, R (2017) 'Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine'. World Journal of Gastroenterology, 23 (41). [DOI]
2017 Murphy, S; Dowling, P; Zweyer, M; Henry, M; Meleady, P; Mundegar, RR; Swandulla, D; Ohlendieck, K (2017) 'Proteomic profiling of mdx-4cv serum reveals highly elevated levels of the inflammation-induced plasma marker haptoglobin in muscular dystrophy'. International Journal of Molecular Medicine, 39 :1357-1370. [DOI]
2017 Henry, M; Power, M; Kaushik, P; Coleman, O; Clynes, M; Meleady, P (2017) 'Differential Phosphoproteomic Analysis of Recombinant Chinese Hamster Ovary Cells Following Temperature Shift'. Journal of Proteome Research, 16 :2339-2358. [DOI]
2017 Lopes-Rodrigues, V; Di Luca, A; Mleczko, J; Meleady, P; Henry, M; Pesic, M; Cabrera, D; van Liempd, S; Lima, RT; O'Connor, R; Falcon-Perez, JM; Vasconcelos, MH (2017) 'Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles'. Scientific Reports, 7 . [DOI]
2017 Ting, KR; Henry, M; Meiller, J; Larkin, A; Clynes, M; Meleady, P; Bazou, D; Dowling, P; O'Gorman, P (2017) 'Novel panel of protein biomarkers to predict response to bortezomib-containing induction regimens in multiple myeloma patients'. BBA Clinical, 8 :28-34. [DOI]
2017 Murphy, S; Brinkmeier, H; Krautwald, M; Henry, M; Meleady, P; Ohlendieck, K (2017) 'Proteomic profiling of the dystrophin complex and membrane fraction from dystrophic mdx muscle reveals decreases in the cytolinker desmoglein and increases in the extracellular matrix stabilizers biglycan and fibronectin'. Journal of Muscle Research and Cell Motility, 38 :251-268. [DOI]
2017 Ting, KR; Henry, M; Meiller, J; Larkin, A; Clynes, M; Meleady, P; Bazou, D; Dowling, P; O' Gorman, P (2017) 'Novel panel of protein biomarkers to predict response to bortezomib-containing induction regimens in multiple myeloma patients'. BBA Clinical, 8 :28-34. [DOI]
2017 Henry, M; Coleman, O; Prashant, ; Clynes, M; Meleady, P (2017) 'Phosphopeptide Enrichment and LC-MS/MS Analysis to Study the Phosphoproteome of Recombinant Chinese Hamster Ovary Cells'. Methods in molecular biology (Clifton, N.J.), 1603 . [DOI]
2017 Coleman, O; Henry, M; Clynes, M; Meleady, P (2017) 'Filter-Aided Sample Preparation (FASP) for Improved Proteome Analysis of Recombinant Chinese Hamster Ovary Cells'. Methods in molecular biology (Clifton, N.J.), 1603 . [DOI]
2017 O' Sullivan, F; Keenan, J; Aherne, S; O' Neill, F; Clarke, C; Henry, M; Meleady, P; Breen, L; Barron, N; Clynes, M; Horgan, K; Doolan, P; Murphy, R (2017) 'Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine'. World Journal of Gastroenterology, 23 :7369-7386. [DOI]
2017 Ting, KR; Henry, M; Meiller, J; Larkin, A; Clynes, M; Meleady, P; Bazou, D; Dowling, P; O'Gorman, P (2017) 'Novel panel of protein biomarkers to predict response to bortezomib-containing induction regimens in multiple myeloma patients'. BBA Clinical, 8 . [DOI]
2017 Meleady, P (2017) 'Two-Dimensional Gel Electrophoresis and 2D-DIGE'. Methods in molecular biology (Clifton, N.J.), 1664 . [DOI]
2017 Henry, Michael; Meleady, Paula (2017) 'Clinical Proteomics: Liquid Chromatography-Mass Spectrometry (LC-MS) Purification Systems'. RNA INTERFERENCE: FROM BIOLOGY TO CLINICAL APPLICATIONS, 1485 . [DOI]
2017 Henry, Michael; Coleman, Orla; Clynes, Martin; Meleady, Paula (2017) 'Phosphopeptide Enrichment and LC-MS/MS Analysis to Study the Phosphoproteome of Recombinant Chinese Hamster Ovary Cells'. RNA INTERFERENCE: FROM BIOLOGY TO CLINICAL APPLICATIONS, 1603 . [DOI]
2017 Coleman, Orla; Henry, Michael; Clynes, Martin; Meleady, Paula (2017) 'Filter-Aided Sample Preparation (FASP) for Improved Proteome Analysis of Recombinant Chinese Hamster Ovary Cells'. RNA INTERFERENCE: FROM BIOLOGY TO CLINICAL APPLICATIONS, 1603 . [DOI]
2017 Murphy, S; Dowling, P; Zweyer, M; Henry, M; Meleady, P; Mundegar, RR; Swandulla, D; Ohlendieck, K (2017) 'Proteomic profiling of mdx-4cv serum reveals highly elevated levels of the inflammation-induced plasma marker haptoglobin in muscular dystrophy'. International Journal of Molecular Medicine, 39 :1357-1370. [DOI]
2016 Sommeregger, W.; Mayrhofer, P.; Steinfellner, W.; Reinhart, D.; Henry, M.; Clynes, M.; Meleady, P.; Kunert, R. (2016) 'Proteomic differences in recombinant CHO cells producing two similar antibody fragments'. Biotechnology and Bioengineering, 113 . [Link] [DOI]
2016 Henry, M; Meleady, P (2016) 'Clinical Proteomics: Liquid Chromatography-Mass Spectrometry (LC-MS) Purification Systems'. Methods in molecular biology (Clifton, N.J.), 1485 . [DOI]
2016 Dowling, P.; Moran, B.; McAuley, E.; Meleady, P.; Henry, M.; Clynes, M.; McMenamin, M.; Leonard, N.; Monks, M.; Wynne, B.; Ormond, P.; Larkin, A. (2016) 'Quantitative label-free mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue representing the invasive cutaneous malignant melanoma proteome'. Oncology Letters, 12 . [Link] [DOI]
2016 Sommeregger W.; Mayrhofer P.; Steinfellner W.; Reinhart D.; Henry M.; Clynes M.; Meleady P.; Kunert R. (2016) 'Proteomic differences in recombinant CHO cells producing two similar antibody fragments'. Biotechnology and Bioengineering, . [DOI]
2016 Murphy, S; Dowling, P; Zweyer, M; Mundegar, RR; Henry, M; Meleady, P; Swandulla, D; Ohlendieck, K (2016) 'Proteomic analysis of dystrophin deficiency and associated changes in the aged mdx-4cv heart model of dystrophinopathy-related cardiomyopathy'. Journal of Proteomics, 145 :24-36. [DOI]
2016 Murphy, S.; Dowling, P.; Zweyer, M.; Mundegar, R.R.; Henry, M.; Meleady, P.; Swandulla, D.; Ohlendieck, K. (2016) 'Proteomic analysis of dystrophin deficiency and associated changes in the aged mdx-4cv heart model of dystrophinopathy-related cardiomyopathy'. Journal of Proteomics, 145 . [Link] [DOI]
2016 Murphy, S; Dowling, P; Zweyer, M; Henry, M; Meleady, P; Mundegar, RR; Swandulla, D; Ohlendieck, K (2016) 'Proteomic profiling of mdx-4cv serum reveals highly elevated levels of the inflammation-induced plasma marker haptoglobin in muscular dystrophy'. International Journal of Molecular Medicine, 39 (6). [DOI]
2016 Dowling, P; Moran, B; McAuley, E; Meleady, P; Henry, M; Clynes, M; McMenamin, M; Leonard, N; Monks, M; Wynne, B; Ormond, P; Larkin, A (2016) 'Quantitative label-free mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue representing the invasive cutaneous malignant melanoma proteome'. Oncology Letters, 12 :3296-3304. [DOI]
2016 Kelly, PS; McSweeney, S; Coleman, O; Carillo, S; Henry, M; Chandran, D; Kellett, A; Bones, J; Clynes, M; Meleady, P; Barron, N (2016) 'Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics'. Biotechnology Progress, 32 (6). [DOI]
2016 Sommeregger, W; Mayrhofer, P; Steinfellner, W; Reinhart, D; Henry, M; Clynes, M; Meleady, P; Kunert, R (2016) 'Proteomic Differences in Recombinant CHO Cells Producing Two Similar Antibody Fragments'. Biotechnology and Bioengineering, 113 :1902-1912. [DOI]
2016 Moloney, NM; Owens, RA; Meleady, P; Henry, M; Dolan, SK; Mulvihill, E; Clynes, M; Doyle, S (2016) 'The iron-responsive microsomal proteome of Aspergillus fumigatus'. Journal of Proteomics, 136 :99-111. [DOI]
2016 Lopes-Rodrigues, V; Di Luca, A; Sousa, D; Seca, H; Meleady, P; Henry, M; Lima, RT; O' Connor, R; Vasconcelos, MH (2016) 'Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells'. Biochimica et Biophysica Acta - General Subjects, 1860 :618-627. [DOI]
2016 Lopes-Rodrigues V.; Di Luca A.; Sousa D.; Seca H.; Meleady P.; Henry M.; Lima R.; O'Connor R.; Vasconcelos M. (2016) 'Data supporting the shedding of larger extracellular vesicles by multidrug resistant tumour cells'. Data In Brief, 6 :1023-1027. [DOI]
2016 Lopes-Rodrigues, V.; Di Luca, A.; Sousa, D.; Seca, H.; Meleady, P.; Henry, M.; Lima, R.T.; O'Connor, R.; Vasconcelos, M.H. (2016) 'Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells'. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1860 . [Link] [DOI]
2016 Lopes-Rodrigues, V; Di Luca, A; Sousa, D; Seca, H; Meleady, P; Henry, M; Lima, RT; O' Connor, R; Vasconcelos, MH (2016) 'Data supporting the shedding of larger extracellular vesicles by multidrug resistant tumour cells'. Data In Brief, 6 :1023-1027. [DOI]
2016 Lopes-Rodrigues, V; Di Luca, A; Sousa, D; Seca, H; Meleady, P; Henry, M; Lima, RT; O' Connor, R; Vasconcelos, MH (2016) 'Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells'. Biochimica et Biophysica Acta - General Subjects, 1860 :618-627. [DOI]
2016 Moloney, NM; Owens, RA; Meleady, P; Henry, M; Dolan, SK; Mulvihill, E; Clynes, M; Doyle, S (2016) 'The iron-responsive microsomal proteome of Aspergillus fumigatus'. Journal of Proteomics, 136 :99-111. [DOI]
2016 Kelly, PS; McSweeney, S; Coleman, O; Carillo, S; Henry, M; Chandran, D; Kellett, A; Bones, J; Clynes, M; Meleady, P; Barron, N (2016) 'Process-Relevant Concentrations of the Leachable bDtBPP Impact Negatively on CHO Cell Production Characteristics'. Biotechnology Progress, 32 :1547-1558. [DOI]
2016 Dowling, P; Moran, B; McAuley, E; Meleady, P; Henry, M; Clynes, M; McMenamin, M; Leonard, N; Monks, M; Wynne, B; Ormond, P; Larkin, A (2016) 'Quantitative label-free mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue representing the invasive cutaneous malignant melanoma proteome'. Oncology Letters, 12 :3296-3304. [DOI]
2016 Sommeregger, W; Mayrhofer, P; Steinfellner, W; Reinhart, D; Henry, M; Clynes, M; Meleady, P; Kunert, R (2016) 'Proteomic Differences in Recombinant CHO Cells Producing Two Similar Antibody Fragments'. Biotechnology and Bioengineering, 113 :1902-1912. [DOI]
2016 Lopes-Rodrigues V.; Di Luca A.; Sousa D.; Seca H.; Meleady P.; Henry M.; Lima R.; O'Connor R.; Vasconcelos M. (2016) 'Data supporting the shedding of larger extracellular vesicles by multidrug resistant tumour cells'. Data In Brief, 6 :1023-1027. [DOI]
2016 Murphy, S; Dowling, P; Zweyer, M; Mundegar, RR; Henry, M; Meleady, P; Swandulla, D; Ohlendieck, K (2016) 'Proteomic analysis of dystrophin deficiency and associated changes in the aged mdx-4cv heart model of dystrophinopathy-related cardiomyopathy'. Journal of Proteomics, 145 :24-36. [DOI]
2016 Dowling, P; Moran, B; McAuley, E; Meleady, P; Henry, M; Clynes, M; McMenamin, M; Leonard, N; Monks, M; Wynne, B; Ormond, P; Larkin, A (2016) 'Quantitative label-free mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue representing the invasive cutaneous malignant melanoma proteome'. Oncology Letters, 12 :3296-3304. [DOI]
2016 Musante, L; Tataruch-Weinert, D; Kerjaschki, D; Henry, M; Meleady, P; Holthofer, H (2016) 'Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment'. Journal Of Extracellular Vesicles, 6 (1). [DOI]
2016 Coleman, O; Henry, M; McVey, G; Clynes, M; Moriarty, M; Meleady, P (2016) 'Proteomic strategies in the search for novel pancreatic cancer biomarkers and drug targets: recent advances and clinical impact'. Expert Review of Proteomics, 13 (4). [DOI]
2015 Murphy, S; Zweyer, M; Henry, M; Meleady, P; Mundegar, RR; Swandulla, D; Ohlendieck, K (2015) 'Label-free mass spectrometric analysis reveals complex changes in the brain proteome from the mdx-4cv mouse model of Duchenne muscular dystrophy'. Clinical Proteomics, 12 . [DOI]
2015 Holland, A.; Dowling, P.; Meleady, P.; Henry, M.; Zweyer, M.; Mundegar, R.R.; Swandulla, D.; Ohlendieck, K. (2015) 'Label-free mass spectrometric analysis of the mdx-4cv diaphragm identifies the matricellular protein periostin as a potential factor involved in dystrophinopathy-related fibrosis'. Proteomics, 15 . [Link] [DOI]
2015 Murphy, S; Henry, M; Meleady, P; Zweyer, M; Mundegar, RR; Swandulla, D; Ohlendieck, K (2015) 'Simultaneous Pathoproteomic Evaluation of the Dystrophin-Glycoprotein Complex and Secondary Changes in the mdx-4cv Mouse Model of Duchenne Muscular Dystrophy'. Biology, 4 (2). [DOI]
2015 Moloney N.; Owens R.; Meleady P.; Henry M.; Dolan S.; Mulvihill E.; Clynes M.; Doyle S. (2015) 'The iron-responsive microsomal proteome of Aspergillus fumigatus'. Journal of Proteomics, . [DOI]
2015 Kelly, P.S.; Breen, L.; Gallagher, C.; Kelly, S.; Henry, M.; Lao, N.T.; Meleady, P.; O'Gorman, D.; Clynes, M.; Barron, N. (2015) 'Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype'. Biotechnology journal, 10 . [Link] [DOI]
2015 Dowling, Paul; Henry, Michael; Meleady, Paula; Clarke, Colin; Gately, Kathy; O'Byrne, Kenneth; Connolly, Elizabeth; Lynch, Vincent; Ballot, Jo; Gullo, Giuseppe; Crown, John; Moriarty, Michael; Clynes, Martin (2015) 'Metabolomic and proteomic analysis of breast cancer patient samples suggests that glutamate and 12-HETE in combination with CA15-3 may be useful biomarkers reflecting tumour burden'. Metabolomics, 11 (3). [DOI]
2015 Murphy, S.; Zweyer, M.; Henry, M.; Meleady, P.; Mundegar, R.R.; Swandulla, D.; Ohlendieck, K. (2015) 'Label-free mass spectrometric analysis reveals complex changes in the brain proteome from the mdx-4cv mouse model of Duchenne muscular dystrophy PediOme'. Clinical Proteomics, 12 . [Link] [DOI]
2015 Holland, A; Henry, M; Meleady, P; Winkler, CK; Krautwald, M; Brinkmeier, H; Ohlendieck, K (2015) 'Comparative Label-Free Mass Spectrometric Analysis of Mildly versus Severely Affected mdx Mouse Skeletal Muscles Identifies Annexin, Lamin, and Vimentin as Universal Dystrophic Markers'. Molecules (Basel, Switzerland), 20 (6). [DOI]
2015 Holland, A; Dowling, P; Meleady, P; Henry, M; Zweyer, M; Mundegar, RR; Swandulla, D; Ohlendieck, K (2015) 'Label-free mass spectrometric analysis of the mdx-4cv diaphragm identifies the matricellular protein periostin as a potential factor involved in dystrophinopathy-related fibrosis'. Proteomics, 15 :2318-2331. [DOI]
2015 Murphy S.; Henry M.; Meleady P.; Zweyer M.; Mundegar R.; Swandulla D.; Ohlendieck K. (2015) 'Simultaneous pathoproteomic evaluation of the dystrophin-glycoprotein complex and secondary changes in the mdx-4cv mouse model of duchenne muscular dystrophy'. Journal of Biology, 4 (2):397-423. [DOI]
2015 Dowling, P; Hughes, DJ; Larkin, AM; Meiller, J; Henry, M; Meleady, P; Lynch, V; Pardini, B; Naccarati, A; Levy, M; Vodicka, P; Neary, P; Clynes, M (2015) 'Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer'. Clinica Chimica Acta, 441 :133-141. [DOI]
2015 Ravida, A; Musante, L; Kreivi, M; Miinalainen, I; Byrne, B; Saraswat, M; Henry, M; Meleady, P; Clynes, M; Holthofer, H (2015) 'Glycosylation patterns of kidney proteins differ in rat diabetic nephropathy'. Kidney International, 87 :963-974. [DOI]
2015 Kelly, PS; Breen, L; Gallagher, C; Kelly, S; Henry, M; Lao, NT; Meleady, P; O' Gorman, D; Clynes, M; Barron, N (2015) 'Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype'. Biotechnology journal, 10 :1029-1040. [DOI]
2015 Holland, A; Henry, M; Meleady, P; Winkler, CK; Krautwald, M; Brinkmeier, H; Ohlendieck, K (2015) 'Comparative Label-Free Mass Spectrometric Analysis of Mildly versus Severely Affected mdx Mouse Skeletal Muscles Identifies Annexin, Lamin, and Vimentin as Universal Dystrophic Markers'. Molecules, 20 :11317-11344. [DOI]
2015 Di Luca, A; Henry, M; Meleady, P; O' Connor, R (2015) 'Label-free LC-MS analysis of HER2+breast cancer cell line response to HER2 inhibitor treatment'. Daru, 23 . [DOI]
2015 Murphy, S; Zweyert, M; Henry, M; Meleady, P; Mundegar, RR; Swandulla, D; Ohlendieck, K (2015) 'Label-free mass spectrometric analysis reveals complex changes in the brain proteome from the mdx-4cv mouse model of Duchenne muscular dystrophy'. Clinical Proteomics, 12 . [DOI]
2015 Di Luca, A.; Henry, M.; Meleady, P.; O'Connor, R. (2015) 'Label-free LC-MS analysis of HER2+ breast cancer cell line response to HER2 inhibitor treatment'. DARU, Journal of Pharmaceutical Sciences, 23 . [Link] [DOI]
2015 Dowling, P; Pollard, D; Larkin, A; Henry, M; Meleady, P; Gately, K; O' Byrne, K; Barr, MP; Lynch, V; Ballot, J; Crown, J; Moriarty, M; O' Brien, E; Morgan, R; Clynes, M (2015) 'Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer'. Molecular BioSystems, 11 :743-752. [DOI]
2015 Dowling, P; Hughes, DJ; Larkin, AM; Meiller, J; Henry, M; Meleady, P; Lynch, V; Pardini, B; Naccarati, A; Levy, M; Vodicka, P; Neary, P; Clynes, M (2015) 'Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer'. Clinica Chimica Acta, 441 :133-141. [DOI]
2015 Ravida, A; Musante, L; Kreivi, M; Miinalainen, I; Byrne, B; Saraswat, M; Henry, M; Meleady, P; Clynes, M; Holthofer, H (2015) 'Glycosylation patterns of kidney proteins differ in rat diabetic nephropathy'. Kidney International, 87 :963-974. [DOI]
2015 Holland, A; Dowling, P; Meleady, P; Henry, M; Zweyer, M; Mundegar, RR; Swandulla, D; Ohlendieck, K (2015) 'Label-free mass spectrometric analysis of the mdx-4cv diaphragm identifies the matricellular protein periostin as a potential factor involved in dystrophinopathy-related fibrosis'. Proteomics, 15 :2318-2331. [DOI]
2015 Murphy S.; Henry M.; Meleady P.; Zweyer M.; Mundegar R.; Swandulla D.; Ohlendieck K. (2015) 'Simultaneous pathoproteomic evaluation of the dystrophin-glycoprotein complex and secondary changes in the mdx-4cv mouse model of duchenne muscular dystrophy'. Journal of Biology, 4 (2):397-423. [DOI]
2015 Murphy, S; Dowling, P; Zweyer, M; Mundegar, RR; Henry, M; Meleady, P; Swandulla, D; Ohlendieck, K (2015) 'Proteomic analysis of dystrophin deficiency and associated changes in the aged mdx-4cv heart model of dystrophinopathy-related cardiomyopathy'. Journal of Proteomics, 145 . [DOI]
2015 Dowling, P; Pollard, D; Larkin, A; Henry, M; Meleady, P; Gately, K; O' Byrne, K; Barr, MP; Lynch, V; Ballot, J; Crown, J; Moriarty, M; O' Brien, E; Morgan, R; Clynes, M (2015) 'Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer'. Molecular BioSystems, 11 :743-752. [DOI]
2015 Dowling, P; Henry, M; Meleady, P; Clarke, C; Gately, K; O' Byrne, K; Connolly, E; Lynch, V; Ballot, J; Gullo, G; Crown, J; Moriarty, M; Clynes, M (2015) 'Metabolomic and proteomic analysis of breast cancer patient samples suggests that glutamate and 12-HETE in combination with CA15-3 may be useful biomarkers reflecting tumour burden'. Metabolomics, 11 :620-635. [DOI]
2015 Kelly, PS; Breen, L; Gallagher, C; Kelly, S; Henry, M; Lao, NT; Meleady, P; O' Gorman, D; Clynes, M; Barron, N (2015) 'Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype'. Biotechnology journal, 10 :1029-1040. [DOI]
2015 Holland, A; Henry, M; Meleady, P; Winkler, CK; Krautwald, M; Brinkmeier, H; Ohlendieck, K (2015) 'Comparative Label-Free Mass Spectrometric Analysis of Mildly versus Severely Affected mdx Mouse Skeletal Muscles Identifies Annexin, Lamin, and Vimentin as Universal Dystrophic Markers'. Molecules, 20 :11317-11344. [DOI]
2015 Dowling, P; Hughes, DJ; Larkin, AM; Meiller, J; Henry, M; Meleady, P; Lynch, V; Pardini, B; Naccarati, A; Levy, M; Vodicka, P; Neary, P; Clynes, M (2015) 'Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer'. Clinica Chimica Acta, 441 :133-141. [DOI]
2015 Di Luca, A; Henry, M; Meleady, P; O' Connor, R (2015) 'Label-free LC-MS analysis of HER2+breast cancer cell line response to HER2 inhibitor treatment'. Daru, 23 . [DOI]
2015 Murphy, S; Zweyer, M; Mundegar, RR; Henry, M; Meleady, P; Swandulla, D; Ohlendieck, K (2015) 'Concurrent Label-Free Mass Spectrometric Analysis of Dystrophin Isoform Dp427 and the Myofibrosis Marker Collagen in Crude Extracts from mdx-4cv Skeletal Muscles'. Proteomes, 3 (3). [DOI]
2015 Murphy, S; Zweyert, M; Henry, M; Meleady, P; Mundegar, RR; Swandulla, D; Ohlendieck, K (2015) 'Label-free mass spectrometric analysis reveals complex changes in the brain proteome from the mdx-4cv mouse model of Duchenne muscular dystrophy'. Clinical Proteomics, 12 . [DOI]
2015 Dowling, P; Hughes, DJ; Larkin, AM; Meiller, J; Henry, M; Meleady, P; Lynch, V; Pardini, B; Naccarati, A; Levy, M; Vodicka, P; Neary, P; Clynes, M (2015) 'Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer'. Clinica Chimica Acta, 441 :133-141. [DOI]
2015 Moloney, NM; Owens, RA; Meleady, P; Henry, M; Dolan, SK; Mulvihill, E; Clynes, M; Doyle, S (2015) 'The iron-responsive microsomal proteome of Aspergillus fumigatus'. Journal of Proteomics, 136 . [DOI]
2015 Kelly, PS; Breen, L; Gallagher, C; Kelly, S; Henry, M; Lao, NT; Meleady, P; O' Gorman, D; Clynes, M; Barron, N (2015) 'Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype'. Biotechnology journal, 10 :1029-1040. [DOI]
2015 Lopes-Rodrigues, V; Di Luca, A; Sousa, D; Seca, H; Meleady, P; Henry, M; Lima, RT; O'Connor, R; Vasconcelos, MH (2015) 'Data supporting the shedding of larger extracellular vesicles by multidrug resistant tumour cells'. Data In Brief, 6 . [DOI]
2014 McCarthy, C; Saldova, R; O' Brien, ME; Bergin, DA; Carroll, TP; Keenan, J; Meleady, P; Henry, M; Clynes, M; Rudd, PM; Reeves, EP; McElvaney, NG (2014) 'Increased Outer Arm and Core Fucose Residues on the N-Glycans of Mutated Alpha-1 Antitrypsin Protein from Alpha-1 Antitrypsin Deficient Individuals'. Journal of Proteome Research, 13 :596-605. [DOI]
2014 Dowling, P; Pollard, D; Larkin, A; Henry, M; Meleady, P; Gately, K; O'Byrne, K; Barr, MP; Lynch, V; Ballot, J; Crown, J; Moriarty, M; O'Brien, E; Morgan, R; Clynes, M (2014) 'Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer'. Molecular BioSystems, 11 (3). [DOI]
2014 Ravidà, A; Musante, L; Kreivi, M; Miinalainen, I; Byrne, B; Saraswat, M; Henry, M; Meleady, P; Clynes, M; Holthofer, H (2014) 'Glycosylation patterns of kidney proteins differ in rat diabetic nephropathy'. Kidney International, 87 (5). [DOI]
2014 Linge, A.; Maurya, P.; Friedrich, K.; Baretton, G.B.; Kelly, S.; Henry, M.; Clynes, M.; Larkin, A.; Meleady, P. (2014) 'Identification and functional validation of rad23b as a potential protein in human breast cancer progression'. Journal of Proteome Research, 13 . [Link] [DOI]
2014 Dowling, P; Palmerini, V; Henry, M; Meleady, P; Lynch, V; Ballot, J; Gullo, G; Crown, J; Moriarty, M; Clynes, M (2014) 'Transferrin-bound proteins as potential biomarkers for advanced breast cancer patients'. BBA Clinical, 2 . [DOI]
2014 Dowling, P; Hughes, DJ; Larkin, AM; Meiller, J; Henry, M; Meleady, P; Lynch, V; Pardini, B; Naccarati, A; Levy, M; Vodicka, P; Neary, P; Clynes, M (2014) 'Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer'. Clinica chimica acta; international journal of clinical chemistry, 441 . [DOI]
2014 Holland, A; Schmitt-John, T; Dowling, P; Meleady, P; Henry, M; Clynes, M; Ohlendieck, K (2014) 'Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry'. Bioscience Reports, 34 (4). [DOI]
2014 McCarthy, Cormac; Saldova, Radka; O'Brien, M. Emmet; Bergin, David. A.; Carroll, Tomas P.; Keenan, Joanne; Meleady, Paula; Henry, Michael; Clynes, Martin; Rudd, Pauline M.; Reeves, Emer P.; McElvaney, Noel G. (2014) 'Increased Outer Arm and Core Fucose Residues on the N-Glycans of Mutated Alpha-1 Antitrypsin Protein from Alpha-1 Antitrypsin Deficient Individuals'. Journal of Proteome Research, 13 (2). [DOI]
2014 Pohl, K; Hayes, E; Keenan, J; Henry, M; Meleady, P; Molloy, K; Jundi, B; Bergin, DA; McCarthy, C; McElvaney, OJ; White, MM; Clynes, M; Reeves, EP; McElvaney, NG (2014) 'A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy'. Blood, 124 (7). [DOI]
2014 Linge, A; Maurya, P; Friedrich, K; Baretton, GB; Kelly, S; Henry, M; Clynes, M; Larkin, A; Meleady, P (2014) 'Identification and Functional Validation of RAD23B as a Potential Protein in Human Breast Cancer Progression'. Journal of Proteome Research, 13 :3212-3222. [DOI]
2014 Linge, A; Maurya, P; Friedrich, K; Baretton, GB; Kelly, S; Henry, M; Clynes, M; Larkin, A*; Meleady, P* (2014) 'Identification and Functional Validation of RAD23B as a Potential Protein in Human Breast Cancer Progression'. Journal of Proteome Research, 13 :3212-3222. [DOI]
2014 McDermott, MSJ; Browne, BC; Conlon, NT; O' Brien, NA; Slamon, DJ; Henry, M; Meleady, P; Clynes, M; Dowling, P; Crown, J; O' Donovan, N (2014) 'PP2A inhibition overcomes acquired resistance to HER2 targeted therapy'. Molecular Cancer, 13 . [DOI]
2014 Dowling P.; Palmerini V.; Henry M.; Meleady P.; Lynch V.; Ballot J.; Gullo G.; Crown J.; Moriarty M.; Clynes M. (2014) 'Transferrin-bound proteins as potential biomarkers for advanced breast cancer patients'. BBA Clinical, 2 :24-30. [DOI]
2014 Pohl, K; Hayes, E; Keenan, J; Henry, M; Meleady, P; Molloy, K; Jundi, B; Bergin, DA; McCarthy, C; McElvaney, OJ; White, MM; Clynes, M; Reeves, EP; McElvaney, NG (2014) 'A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy'. Blood, 124 :999-1009. [DOI]
2014 Holland, A; Schmitt-John, T; Dowling, P; Meleady, P; Henry, M; Clynes, M; Ohlendieck, K (2014) 'Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry'. Bioscience Reports, 34 :331-343. [DOI]
2014 McCarthy, C; Saldova, R; O' Brien, ME; Bergin, DA; Carroll, TP; Keenan, J; Meleady, P; Henry, M; Clynes, M; Rudd, PM; Reeves, EP; McElvaney, NG (2014) 'Increased Outer Arm and Core Fucose Residues on the N-Glycans of Mutated Alpha-1 Antitrypsin Protein from Alpha-1 Antitrypsin Deficient Individuals'. Journal of Proteome Research, 13 :596-605. [DOI]
2014 Holland, A; Schmitt-John, T; Dowling, P; Meleady, P; Henry, M; Clynes, M; Ohlendieck, K (2014) 'Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry'. Bioscience Reports, 34 :331-343. [DOI]
2014 Dowling P.; Palmerini V.; Henry M.; Meleady P.; Lynch V.; Ballot J.; Gullo G.; Crown J.; Moriarty M.; Clynes M. (2014) 'Transferrin-bound proteins as potential biomarkers for advanced breast cancer patients'. BBA Clinical, 2 :24-30. [DOI]
2014 McDermott, MSJ; Browne, BC; Conlon, NT; O' Brien, NA; Slamon, DJ; Henry, M; Meleady, P; Clynes, M; Dowling, P; Crown, J; O' Donovan, N (2014) 'PP2A inhibition overcomes acquired resistance to HER2 targeted therapy'. Molecular Cancer, 13 . [DOI]
2014 Pohl, K; Hayes, E; Keenan, J; Henry, M; Meleady, P; Molloy, K; Jundi, B; Bergin, DA; McCarthy, C; McElvaney, OJ; White, MM; Clynes, M; Reeves, EP; McElvaney, NG (2014) 'A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy'. Blood, 124 :999-1009. [DOI]
2014 Linge, A; Maurya, P; Friedrich, K; Baretton, GB; Kelly, S; Henry, M; Clynes, M; Larkin, A; Meleady, P (2014) 'Identification and Functional Validation of RAD23B as a Potential Protein in Human Breast Cancer Progression'. Journal of Proteome Research, 13 :3212-3222. [DOI]
2013 Sanchez, N; Gallagher, M; Lao, N; Gallagher, C; Clarke, C; Doolan, P; Aherne, S; Blanco, A; Meleady, P; Clynes, M; Barron, N (2013) 'MiR-7 Triggers Cell Cycle Arrest at the G1/S Transition by Targeting Multiple Genes Including Skp2 and Psme3'. PLoS ONE, 8 . [DOI]
2013 Doolan, P; Clarke, C; Kinsella, P; Breen, L; Meleady, P; Leonard, M; Zhang, L; Clynes, M; Aherne, ST; Barron, N (2013) 'Transcriptomic analysis of clonal growth rate variation during CHO cell line development'. Journal of Biotechnology, 166 :105-113. [DOI]
2013 McDermott, MS; Browne, BC; Conlon, NT; O'Brien, NA; Slamon, DJ; Henry, M; Meleady, P; Clynes, M; Dowling, P; Crown, J; O'Donovan, N (2013) 'PP2A inhibition overcomes acquired resistance to HER2 targeted therapy'. Molecular Cancer, 13 . [DOI]
2013 Ramasamy, P; Murphy, CC; Clynes, M; Horgan, N; Moriarty, P; Tiernan, D; Beatty, S; Kennedy, S; Meleady, P (2013) 'Proteomics in uveal melanoma'. Experimental Eye Research, 118 . [DOI]
2013 Doolan, P; Clarke, C; Kinsella, P; Breen, L; Meleady, P; Leonard, M; Zhang, L; Clynes, M; Aherne, ST; Barron, N (2013) 'Transcriptomic analysis of clonal growth rate variation during CHO cell line development'. Journal of Biotechnology, 166 :105-113. [DOI]
2012 Clarke, C; Henry, M; Doolan, P; Kelly, S; Aherne, S; Sanchez, N; Kelly, P; Kinsella, P; Breen, L; Madden, SF; Zhang, L; Leonard, M; Clynes, M; Meleady, P; Barron, N (2012) 'Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate'. BMC Genomics, 13 . [DOI]
2012 Linge, A.; Kennedy, S.; O'Flynn, D.; Beatty, S.; Moriarty, P.; Henry, M.; Clynes, M.; Larkin, A.; Meleady, P. (2012) 'Differential expression of fourteen proteins between uveal melanoma from patients who subsequently developed distant metastases versus those who did not'. Investigative Ophthalmology and Visual Science, 53 . [Link] [DOI]
2012 O' Connell, K; Prencipe, M; O' Neill, A; Corcoran, C; Rani, S; Henry, M; Dowling, P; Meleady, P; O' Driscoll, L; Watson, W; O' Connor, R (2012) 'The use of LC-MS to identify differentially expressed proteins in docetaxel-resistant prostate cancer cell lines'. Proteomics, 12 :2115-2126. [DOI]
2012 Zaborowska I, Kellner K, Henry M, Meleady P, Walsh D (2012) 'Recruitment of host translation initiation factor eIF4G by the Vaccinia Virus ssDNA-binding protein I3'. Virology, 425 :11-22.
2012 Meleady P, Gallagher M, Clarke C, Henry M, Sanchez N, Barron N, Clynes M (2012) 'Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells'. Journal of Biotechnology, 160 :251-262.
2012 Linge A, Kennedy S, O'Flynn D, Beatty S, Moriarty P, Henry M, Clynes M, Larkin A, Meleady P. (2012) 'Differential expression of fourteen proteins between uveal melanoma from patients who subsequently developed distant metastases versus those who did not'. INVESTIGATIVE OPTHAMOLOGY & VISUAL SCIENCE, 53 :4634-4643.
2012 Meleady P, Hoffrogge R, Henry M, Rupp O, Bort JH, Clarke C, Brinkrolf K, Kelly S, Müller B, Doolan P, Hackl M, Beckmann TF, Noll T, Grillari J, Barron N, Pühler A, Clynes M, Borth N. (2012) 'Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics'. Biotechnology and Bioengineering, 109 :1386-1394.
2012 Clarke, C; Henry, M; Doolan, P; Kelly, S; Aherne, S; Sanchez, N; Kelly, P; Kinsella, P; Breen, L; Madden, SF; Zhang, L; Leonard, M; Clynes, M; Meleady, P; Barron, N (2012) 'Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate'. BMC Genomics, 13 . [DOI]
2012 Clarke C, Doolan P, Barron N, Meleady P, Madden SF, DiNino D, Leonard M, Clynes M. (2012) 'CGCDB: a web-based resource for the investigation of gene coexpression in CHO cell culture'. Biotechnology and Bioengineering, 109 :1368-1370.
2012 Reeves EP, Bergin DA, Fitzgerald S, Hayes E, Keenan J, Henry M, Meleady P, Vega-Carrascal I, Murray MA, Low TB, McCarthy C, O’Brien E, Clynes M, Gunaratnam C, McElvaney NG (2012) 'A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis'. Journal Of Cystic Fibrosis, 11 :100-107.
2012 Doolan P, Barron N, Kinsella P, Clarke C, Meleady P, O’Sullivan F, Melville M, Leonard M, Clynes M (2012) 'Microarray expression profiling identifies several genes associated with regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines'. Biotechnology journal, 7 :516-526.
2012 Meleady, P.; Gallagher, M.; Clarke, C.; Henry, M.; Sanchez, N.; Barron, N.; Clynes, M. (2012) 'Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells'. Journal of Biotechnology, 160 . [Link] [DOI]
2012 Zaborowska, I.; Kellner, K.; Henry, M.; Meleady, P.; Walsh, D. (2012) 'Recruitment of host translation initiation factor eIF4G by the Vaccinia Virus ssDNA-binding protein I3'. Virology, 425 . [Link] [DOI]
2012 O'Connell, Kathleen; Prencipe, Maria; O'Neill, Amanda; Corcoran, Claire; Rani, Sweta; Henry, Michael; Dowling, Paul; Meleady, Paula; O'Driscoll, Lorraine; Watson, William; O'Connor, Robert (2012) 'The use of LC-MS to identify differentially expressed proteins in docetaxel-resistant prostate cancer cell lines'. Proteomics, 12 (13). [DOI]
2012 Zaborowska, I; Kellner, K; Henry, M; Meleady, P; Walsh, D (2012) 'Recruitment of host translation initiation factor eIF4G by the Vaccinia Virus ssDNA-binding protein I3'. Virology, 425 :11-22. [DOI]
2012 Clarke, C; Henry, M; Doolan, P; Kelly, S; Aherne, S; Sanchez, N; Kelly, P; Kinsella, P; Breen, L; Madden, SF; Zhang, L; Leonard, M; Clynes, M; Meleady, P; Barron, N (2012) 'Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate'. BMC Genomics, 13 . [DOI]
2012 O' Connell, K; Prencipe, M; O' Neill, A; Corcoran, C; Rani, S; Henry, M; Dowling, P; Meleady, P; O' Driscoll, L; Watson, W; O' Connor, R (2012) 'The use of LC-MS to identify differentially expressed proteins in docetaxel-resistant prostate cancer cell lines'. Proteomics, 12 :2115-2126. [DOI]
2012 Linge, A; Kennedy, S; O'Flynn, D; Beatty, S; Moriarty, P; Henry, M; Clynes, M; Larkin, A*; Meleady, P* (2012) 'Differential Expression of Fourteen Proteins between Uveal Melanoma from Patients Who Subsequently Developed Distant Metastases versus Those Who Did Not'. Investigative Ophthalmology & Visual Science, 53 :4634-4643. [DOI]
2012 Linge, A; Kennedy, S; O' Flynn, D; Beatty, S; Moriarty, P; Henry, M; Clynes, M; Larkin, A; Meleady, P (2012) 'Differential Expression of Fourteen Proteins between Uveal Melanoma from Patients Who Subsequently Developed Distant Metastases versus Those Who Did Not'. Investigative Ophthalmology & Visual Science, 53 :4634-4643. [DOI]
2012 Meleady, P; Gallagher, M; Clarke, C; Henry, M; Sanchez, N; Barron, N; Clynes, M (2012) 'Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells'. Journal of Biotechnology, 160 :251-262. [DOI]
2012 Meleady, P; Hoffrogge, R; Henry, M; Rupp, O; Bort, JH; Clarke, C; Brinkrolf, K; Kelly, S; Muller, B; Doolan, P; Hackl, M; Beckmann, TF; Noll, T; Grillari, J; Barron, N; Puhler, A; Clynes, M; Borth, N (2012) 'Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics'. Biotechnology and Bioengineering, 109 :1386-1394. [DOI]
2012 Reeves, Emer P.; Bergin, David A.; Fitzgerald, Sean; Hayes, Elaine; Keenan, Joanne; Henry, Michael; Meleady, Paula; Vega-Carrascal, Isabel; Murray, Michelle A.; Low, Teck Boon; McCarthy, Cormac; O'Brien, Emmet; Clynes, Martin; Gunaratnam, Cedric; McElvaney, Noel G. (2012) 'A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis'. JOURNAL OF CYSTIC FIBROSIS, 11 (2). [DOI]
2012 Doolan, P; Clarke, C; Kinsella, P; Breen, L; Meleady, P; Leonard, M; Zhang, L; Clynes, M; Aherne, ST; Barron, N (2012) 'Transcriptomic analysis of clonal growth rate variation during CHO cell line development'. Journal of Biotechnology, 166 (3). [DOI]
2012 Clarke, C; Henry, M; Doolan, P; Kelly, S; Aherne, S; Sanchez, N; Kelly, P; Kinsella, P; Breen, L; Madden, SF; Zhang, L; Leonard, M; Clynes, M; Meleady, P; Barron, N (2012) 'Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate'. BMC Genomics, 13 . [DOI]
2012 Sanchez, N; Gallagher, M; Lao, N; Gallagher, C; Clarke, C; Doolan, P; Aherne, S; Blanco, A; Meleady, P; Clynes, M; Barron, N (2012) 'MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3'. PLoS ONE, 8 (6). [DOI]
2011 Henry, Michael; Meleady, Paula (2011) 'Clinical Proteomics: Liquid Chromatography-Mass Spectrometry Purification Systems'. RNA INTERFERENCE: FROM BIOLOGY TO CLINICAL APPLICATIONS, 681 . [DOI]
2011 Clarke, C.; Doolan, P.; Barron, N.; Meleady, P.; O'Sullivan, F.; Gammell, P.; Melville, M.; Leonard, M.; Clynes, M. (2011) 'Predicting cell-specific productivity from CHO gene expression'. Journal of Biotechnology, 151 . [Link] [DOI]
2011 Eustace AJ, Dowling P, Henry M, Doolan P, Meleady P, Clynes M, Crown J, O'Donovan N. (2011) '2D-DIGE analysis of phospho-enriched fractions from dasatinib-treated melanoma cell lines'. Journal of Proteomics, 74 :490-501.
2011 Barron, N.; Kumar, N.; Sanchez, N.; Doolan, P.; Clarke, C.; Meleady, P.; O'Sullivan, F.; Clynes, M. (2011) 'Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7'. Journal of Biotechnology, 151 . [Link] [DOI]
2011 Meleady, P (2011) '2D gel electrophoresis and mass spectrometry identification and analysis of proteins'. Methods in molecular biology (Clifton, N.J.), 784 . [DOI]
2011 Meleady, P; Doolan, P; Henry, M; Barron, N; Keenan, J; O' Sullivan, F; Clarke, C; Gammell, P; Melville, MW; Leonard, M; Clynes, M (2011) 'Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype'. BMC Biotechnology, 11 . [DOI]
2011 Eustace, AJ; Dowling, P; Henry, M; Doolan, P; Meleady, P; Clynes, M; Crown, J; O' Donovan, N (2011) '2D-DIGE analysis of phospho-enriched fractions from dasatinib-treated melanoma cell lines'. Journal of Proteomics, 74 :490-501. [DOI]
2011 Egan, B; Dowling, P; O' Connor, PL; Henry, M; Meleady, P; Zierath, JR; O' Gorman, DJ (2011) '2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training'. Proteomics, 11 :1413-1428. [DOI]
2011 Meleady, P.; Doolan, P.; Henry, M.; Barron, N.; Keenan, J.; O'Sullivan, F.; Clarke, C.; Gammell, P.; Melville, M.W.; Leonard, M.; Clynes, M. (2011) 'Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: Proteome analysis of the molecular basis for a process-related phenotype'. BMC Biotechnology, 11 . [Link] [DOI]
2011 Linge, A.; Meleady, P.; Henry, M.; Clynes, M.; Kasper, M.; Barth, K. (2011) 'Bleomycin treatment of A549 human lung cancer cells results in association of MGr1-Ag and caveolin-1 in lipid rafts'. International Journal of Biochemistry and Cell Biology, 43 . [Link] [DOI]
2011 Egan, B.; Dowling, P.; O'Connor, P.L.; Henry, M.; Meleady, P.; Zierath, J.R.; O'Gorman, D.J. (2011) '2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training'. Proteomics, 11 . [Link] [DOI]
2011 Clarke C, Doolan, P., Barron, N., Meleady, P., O'Sullivan, F., Gammell, P., Melville, M., Leonard, M., Clynes, M (2011) 'Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity'. Journal of Biotechnology, 155 :350-359.
2011 Barron N, Kumar N, Sanchez N, Doolan P, Clarke C, Meleady P, O'Sullivan F, Clynes M. (2011) 'Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7'. Journal of Biotechnology, 151 :204-211.
2011 Meleady P, Doolan P, Henry M, Barron N, Keenan J, O'Sullivan F, Clarke C, Gammell P, Melville M, Leonard M, Clynes M. (2011) 'Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype'. BMC Biotechnology, 11 .
2011 Egan E, Dowling P, O’Connor PL, Henry M, Meleady P, Zierath JR, O’Gorman (2011) '2D-DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training'. Proteomics, 11 :1413-1428.
2011 Clarke, C., Doolan, P., Barron, N., Meleady, P., O'Sullivan, F., Gammell, P., Melville, M., Leonard, M., Clynes, M. (2011) 'Predicting cell-specific productivity from CHO gene expression'. Journal of Biotechnology, 151 :159-165.
2011 Clarke, C; Doolan, P; Barron, N; Meleady, P; O'Sullivan, F; Gammell, P; Melville, M; Leonard, M; Clynes, M (2011) 'Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity'. Journal of Biotechnology, 155 (3). [DOI]
2011 Clarke, C; Doolan, P; Barron, N; Meleady, P; Madden, SF; DiNino, D; Leonard, M; Clynes, M (2011) 'CGCDB: a web-based resource for the investigation of gene coexpression in CHO cell culture'. Biotechnology and Bioengineering, 109 (6). [DOI]
2011 Meleady, P; Hoffrogge, R; Henry, M; Rupp, O; Bort, JH; Clarke, C; Brinkrolf, K; Kelly, S; Müller, B; Doolan, P; Hackl, M; Beckmann, TF; Noll, T; Grillari, J; Barron, N; Pühler, A; Clynes, M; Borth, N (2011) 'Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics'. Biotechnology and Bioengineering, 109 (6). [DOI]
2011 Doolan, P; Barron, N; Kinsella, P; Clarke, C; Meleady, P; O'Sullivan, F; Melville, M; Leonard, M; Clynes, M (2011) 'Microarray expression profiling identifies genes regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines'. Biotechnology journal, 7 (4). [DOI]
2011 Linge, Annett; Meleady, Paula; Henry, Michael; Clynes, Martin; Kasper, Michael; Barth, Kathrin (2011) 'Bleomycin treatment of A549 human lung cancer cells results in association of MGr1-Ag and caveolin-1 in lipid rafts'. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 43 (1). [DOI]
2011 Dowling, Paul; Clynes, Martin; Meleady, Paula (2011) 'Sample Preparation Techniques for Cancer Proteomics'. Sample Preparation In Biological Mass Spectrometry, . [DOI]
2010 Bergin, DA; Reeves, EP; Meleady, P; Henry, M; McElvaney, OJ; Carroll, TP; Condron, C; Chotirmall, SH; Clynes, M; O' Neill, SJ; McElvaney, NG (2010) 'alpha-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8'. Journal of Clinical Investigation, 120 :4236-4250. [DOI]
2010 Dowling, P.; Meleady, P.; Henry, M.; Clynes, M. (2010) 'Recent advances in clinical proteomics using mass spectrometry'. Bioanalysis, 2 . [Link] [DOI]
2010 Doolan P, Meleady P, Barron N, Henry M, Gallagher R, Gammell P, Melville M, Sinacore M, McCarthy K, Leonard M, Charlebois T, Clynes M (2010) 'Microarray and proteomics expression profiling identifies several candidates, including the Valosin-containing Protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines'. Biotechnology and Bioengineering, 106 :42-56.
2010 Linge A, Meleady P, Henry M, Clynes M, Kasper M, Barth K. (2010) 'Bleomycin treatment of A549 human lung cancer cells results in association of MGr1-Ag and caveolin-1 in lipid rafts'. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, .
2010 Bergin D, Reeves E, Meleady P, Henry M, McElvaney O, Carroll T, Condron C, Chotirmall S, Clynes M, O'Neill S, McElvaney NG. (2010) 'Alpha-1 antitrypsin regulates immune complex and interleukin-8 induced neutrophil chemotaxis'. Journal of Clinical Investigation, in press .
2010 Dowling P.; Meleady P.; Henry M.; Clynes M. (2010) 'Recent advances in clinical proteomics using mass spectrometry'. Bioanalysis, 2 (9):1609-1615. [DOI]
2010 Henry, M; Meleady, P (2010) 'Clinical proteomics: liquid chromatography-mass spectrometry purification systems'. Methods in molecular biology (Clifton, N.J.), 681 .
2010 Dowling, P; Meleady, P; Henry, M; Clynes, M (2010) 'Recent advances in clinical proteomics using mass spectrometry'. Bioanalysis, 2 (9). [DOI]
2010 Bergin, D.A.; Reeves, E.P.; Meleady, P.; Henry, M.; McElvaney, O.J.; Carroll, T.P.; Condron, C.; Chotirmall, S.H.; Clynes, M.; O'Neill, S.J.; McElvaney, N.G. (2010) 'α-1 antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8'. Journal of Clinical Investigation, 120 . [Link] [DOI]
2010 Doolan, P; Meleady, P; Barron, N; Henry, M; Gallagher, R; Gammell, P; Melville, M; Sinacore, M; McCarthy, K; Leonard, M; Charlebois, T; Clynes, M (2010) 'Microarray and Proteomics Expression Profiling Identifies Several Candidates, Including the Valosin-Containing Protein (VCP), Involved in Regulating High Cellular Growth Rate in Production CHO Cell Lines'. Biotechnology and Bioengineering, 106 :42-56. [DOI]
2010 Eustace, AJ; Dowling, P; Henry, M; Doolan, P; Meleady, P; Clynes, M; Crown, J; O'Donovan, N (2010) '2D-DIGE analysis of phospho-enriched fractions from dasatinib-treated melanoma cell lines'. Journal of Proteomics, 74 (4). [DOI]
2009 Walsh,N ., O'Donovan, N., Kennedy, S., Henry, M.,Meleady, P., Clynes,M., Dowling, P. (2009) 'Identification of pancreatic cancer invasion-related proteins by proteomic analysis. '. Proteome Science, 7 . [DOI]
2009 Walsh N, O'Donovan N, Kennedy S, Henry M, Meleady P, Clynes M, Dowling P. (2009) 'Identification of pancreatic cancer invasion-related proteins by proteomic analysis'. Proteome Science, 7 .
2009 Muniyappa, M.K.; Dowling, P.; Henry, M.; Meleady, P.; Doolan, P.; Gammell, P.; Clynes, M.; Barron, N. (2009) 'MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines'. European journal of Cancer, 45 . [Link] [DOI]
2009 Keenan, J., Murphy, L.,Henry, M.,Meleady, P., Clynes, M (2009) 'Proteomic analysis of multidrug-resistance mechanisms in adriamycin-resistant variants of DLKP, a squamous lung cancer cell line'. Proteomics, 9 :1556-1566. [DOI]
2009 Keenan, J; Murphy, L; Henry, M; Meleady, P; Clynes, M (2009) 'Proteomic analysis of multidrug-resistance mechanisms in adriamycin-resistant variants of DLKP, a squamous lung cancer cell line'. Proteomics, 9 :1556-1566. [DOI]
2009 Walsh, N; O' Donovan, N; Kennedy, S; Henry, M; Meleady, P; Clynes, M; Dowling, P (2009) 'Identification of pancreatic cancer invasion-related proteins by proteomic analysis'. Proteome Science, 7 . [DOI]
2009 Muniyappa MK, Dowling P, Henry M, Meleady P, Doolan P, Gammell P, Clynes M, Barron N. (2009) 'MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines'. European journal of Cancer, 45 :3104-3118.
2009 Keenan J, Murphy L, Henry M, Meleady P, Clynes M. (2009) 'Proteomic analysis of multidrug-resistance mechanisms in adriamycin-resistant variants of DLKP, a squamous lung cancer cell line'. Proteomics, 9 :1556-1566.
2009 Muniyappa, MK; Dowling, P; Henry, M; Meleady, P; Doolan, P; Gammell, P; Clynes, M; Barron, N (2009) 'MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines'. European Journal of Cancer. Part A, 45 :3104-3118. [DOI]
2009 Keenan, J.; Murphy, L.; Henry, M.; Meleady, P.; Clynes, M. (2009) 'Proteomic analysis of multidrug-resistance mechanisms in adriamycin-resistant variants of DLKP, a squamous lung cancer cell line'. Proteomics, 9 . [Link] [DOI]
2008 Murphy, L.; Henry, M.; Meleady, P.; Clynes, M.; Keenan, J. (2008) 'Proteomic investigation of taxol and taxotere resistance and invasiveness in a squamous lung carcinoma cell line'. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1784 (9). [DOI]
2008 Walsh, N; O'Donovan, N; Kennedy, S; Henry, M; Meleady, P; Clynes, M; Dowling, P (2008) 'Identification of pancreatic cancer invasion-related proteins by proteomic analysis'. Proteome Science, 7 . [DOI]
2008 Doolan, Padraig; Melville, Mark; Gammell, Patrick; Sinacore, Martin; Meleady, Paula; McCarthy, Kevin; Francullo, Linda; Leonard, Mark; Charlebois, Timothy; Clynes, Martin (2008) 'Transcriptional profiling of gene expression changes in a PACE-transfected CHO DUKX cell line secreting high levels of rhBMP-2'. Molecular Biotechnology, 39 (3). [DOI]
2008 Dowling, P; Shields, W; Rani, S; Meleady, P; Henry, M; Jeppesen, P; O'Driscoll, L; Clynes, M (2008) 'Proteomic analysis of conditioned media from glucose responsive and glucose non-responsive phenotypes reveals a panel of secreted proteins associated with beta cell dysfunction'. Electrophoresis, 29 (20). [DOI]
2008 Dowling, P; Wormald, R; Meleady, P; Henry, M; Curran, A; Clynes, M (2008) 'Analysis of the saliva proteome from patients with head and neck squamous cell carcinoma reveals differences in abundance levels of proteins associated with tumour progression and metastasis'. Journal of Proteomics, 71 (2). [DOI]
2008 Dowling, P; Shields, W; Rani, S; Meleady, P; Henry, M; Jeppesen, P; O' Driscoll, L; Clynes, M (2008) 'Proteomic analysis of conditioned media from glucose responsive and glucose nonresponsive phenotypes reveals a panel of secreted proteins associated with beta cell dysfunction'. Electrophoresis, 29 :4141-4149. [DOI]
2008 Kumar N., Gammell P, Meleady P, Henry M. & Clynes M (2008) 'Proteome Analysis of Differential Protein Expression Following Low Temperature Culture of Suspension CHO-K1 Cells'. BMC Biotechnology, 8 .
2008 Murphy L, Henry M, Meleady P, Clynes M, Keenan J Dr. Paula Meleady (2008) 'Proteomic investigation of taxol and taxotere resistance and invasiveness in a squamous lung carcinoma cell line'. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1784 :1184-1191.
2008 Walsh N, Dowling P, O’Donovan N, Henry M, Meleady P, Clynes M (2008) 'Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells'. Journal of Proteomics, 2 :561-571.
2008 Doolan P*, Melville M* Gammell P, Sinacore M, Meleady P, McCarthy K, Francullo L, Leonard M, Charlebois T, Clynes M. (2008) 'Transcriptional profiling of gene expression changes in a PACE-transfected CHO DUKX cell line secreting high levels of rhBMP-2'. Molecular Biotechnology, 39 :187-199.
2008 Murphy, L; Henry, M; Meleady, P; Clynes, M; Keenan, J (2008) 'Proteomic investigation of taxol and taxotere resistance and invasiveness in a squamous lung carcinoma cell line'. Biochimica et Biophysica Acta - Proteins and Proteomics, 1784 :1184-1191. [DOI]
2008 Meleady, P; Henry, M; Gammell, P; Doolan, P; Sinacore, M; Melville, M; Francullo, L; Leonard, M; Charlebois, T; Clynes, M (2008) 'Proteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol'. Proteomics, 8 :2611-2624. [DOI]
2008 Dowling, P; Wormald, R; Meleady, P; Henry, M; Curran, A; Clynes, M (2008) 'Analysis of the saliva proteome from patients with head and neck squamous cell carcinoma reveals differences in abundance levels of proteins associated with tumour progression and metastasis'. Journal of Proteomics, 71 :168-175. [DOI]
2008 Dowling P, Wormald R, Meleady P, Henry M, Curran A, Clynes M (2008) 'Analysis of the saliva proteome from patients with head and neck squamous cell carcinoma reveals differences in abundance levels of proteins associated with tumour progression and metastasis'. Journal of Proteomics, 71 :168-175.
2008 Kumar N*, Maurya P*, Gammell P, Clynes M & Meleady P (2008) 'Proteomic profiling of secreted proteins from CHO cells using Surface Enhanced Laser Desorption Ionisation Time of Flight Mass Spectrometry (SELDI-TOF MS)'. Biotechnology Progress, 24 :273-278.
2008 Meleady P, Henry M, Gammell P, Doolan P, Sinacore M, Melville M, Francullo L, Leonard M, Charlebois T, & Clynes M. (2008) 'Proteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol '. Proteomics, 8 :2611-2624.
2008 Kumar, N; Gammell, P; Meleady, P; Henry, M; Clynes, M (2008) 'Differential protein expression following low temperature culture of suspension CHO-K1 cells'. BMC Biotechnology, 8 . [DOI]
2008 Daly, N; Meleady, P; Walsh, D; Clynes, M (2008) 'Regulation of keratin and integrin gene expression in cancer and drug resistance'. Cytotechnology, 27 (1-3). [DOI]
2008 Kumar, N; Maurya, P; Gammell, P; Dowling, P; Clynes, M; Meleady, P (2008) 'Proteomic profiling of secreted proteins from CHO cells using Surface-Enhanced Laser desorption ionization time-of-flight mass spectrometry'. Biotechnology Progress, 24 (1). [DOI]
2008 Meleady, P; Henry, M; Gammell, P; Doolan, P; Sinacore, M; Melville, M; Francullo, L; Leonard, M; Charlebois, T; Clynes, M (2008) 'Proteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol'. Proteomics, 8 (13). [DOI]
2008 Kumar, Niraj; Maurya, Priyanka; Ganunell, Patrick; Dowling, Paul; Clynes, Martin; Meleady, Paula (2008) 'Proteomic profiling of secreted proteins from CHO cells using surface-enhanced laser desorption ionization time-of-flight mass spectrometry'. Biotechnology Progress, 24 (1). [DOI]
2007 Dowling, P.; Maurya, P.; Meleady, P.; Glynn, S. A.; Dowd, A. J.; Henry, M.; Clynes, M. (2007) 'Purification and identification of a 7.6-kDa protein in media conditioned by superinvasive cancer cells'. Anticancer Research, 27 (3A).
2007 Dowling, P.; Maurya, P.; Meleady, P.; Glynn, S.A.; Dowd, A.J.; Henry, M.; Clynes, M. (2007) 'Purification and identification of a 7.6-kDa protein in media conditioned by superinvasive cancer cells'. Anticancer Research, . [Link]
2007 Dowling, P; Maurya, P; Meleady, P; Glynn, SA; Dowd, AJ; Henry, M; Clynes, M (2007) 'Purification and identification of a 7.6-kDa protein in media conditioned by superinvasive cancer cells'. Anticancer Research, 27 (3A).
2007 Dowling P, O’ Driscoll L, Meleady P, Henry M, Roy S, Ballot J, Moriarty M, Crown J, Clynes M (2007) 'Two-dimensional difference gel electrophoresis of the lung squamous cell carcinoma versus normal sera demonstrates consistent alterations in the levels of 10 specific proteins'. 28 :4302-4310.
2007 Dowling P, O’ Driscoll L, Meleady P, Henry M, Roy S, Ballot J, Moriarty M, Crown J, Clynes (2007) 'Two-dimensional difference gel electrophoresis of the lung squamous cell carcinoma versus normal sera demonstrates consistent alterations in the levels of 10 specific proteins'. 28 :4302-4310.
2007 Dowling P, Meleady P, Dowd A, Henry M, Glynn S, Clynes M (2007) 'Proteomic analysis of isolated membrane fractions from superinvasive cancer cells'. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1774 :93-101.
2007 Dowling P, Maurya P, Meleady P, Glynn SA, Dowd AJ, Henry M, Clynes M. (2007) 'Purification and Identification of a 7.6kDa Protein in Media Conditioned by Superinvasive Cancer Cells'. Anticancer Research, 27 :1309-1317.
2007 Dowling, P; O' Driscoll, L; Meleady, P; Henry, M; Roy, S; Ballot, J; Moriarty, M; Crown, J; Clynes, M (2007) '2-D difference gel electrophoresis of the lung squamous cell carcinoma versus normal sera demonstrates consistent alterations in the levels of ten specific proteins'. Electrophoresis, 28 :4302-4310. [DOI]
2007 Dowling, P; Meleady, P; Dowd, A; Henry, M; Glynn, S; Clynes, M (2007) 'Proteomic analysis of isolated membrane fractions from superinvasive cancer cells'. Biochimica et Biophysica Acta - Proteins and Proteomics, 1774 :93-101. [DOI]
2007 Maurya, P; Meleady, P; Dowling, P; Clynes, M (2007) 'Proteomic approaches for serum biomarker discovery in cancer'. Anticancer Research, 27 (3A).
2007 Murphy, L; Henry, M; Meleady, P; Clynes, M; Keenan, J (2007) 'Proteomic investigation of taxol and taxotere resistance and invasiveness in a squamous lung carcinoma cell line'. Biochimica et biophysica acta, 1784 (9). [DOI]
2007 Doolan, P; Melville, M; Gammell, P; Sinacore, M; Meleady, P; McCarthy, K; Francullo, L; Leonard, M; Charlebois, T; Clynes, M (2007) 'Transcriptional profiling of gene expression changes in a PACE-transfected CHO DUKX cell line secreting high levels of rhBMP-2'. Molecular Biotechnology, 39 (3). [DOI]
2007 Maurya, Priyanka; Meleady, Paula; Dowling, Paul; Clynes, Martin (2007) 'Proteomic approaches for serum biomarker discovery in cancer'. Anticancer Research, 27 (3A).
2007 Kumar, N; Gammell, P; Meleady, P; Henry, M; Clynes, M (2007) 'Differential protein expression following low temperature culture of suspension CHO-K1 cells'. BMC Biotechnology, 8 . [DOI]
2007 Dowling, P.; O'Driscoll, L.; Meleady, P.; Henry, M.; Roy, S.; Ballot, J.; Moriarty, M.; Crown, J.; Clynes, M. (2007) '2-D difference gel electrophoresis of the lung squamous cell carcinoma versus normal sera demonstrates consistent alterations in the levels of ten specific proteins'. Electrophoresis, 28 . [Link] [DOI]
2007 Dowling, P.; Meleady, P.; Dowd, A.; Henry, M.; Glynn, S.; Clynes, M. (2007) 'Proteomic analysis of isolated membrane fractions from superinvasive cancer cells'. Biochimica et Biophysica Acta - Proteins and Proteomics, 1774 . [Link] [DOI]
2006 Dowling, P; Meleady, P; Dowd, A; Henry, M; Glynn, S; Clynes, M (2006) 'Proteomic analysis of isolated membrane fractions from superinvasive cancer cells'. Biochimica et biophysica acta, 1774 (1). [DOI]
2006 Dowling, P.; O'Driscoll, L.; O'Sullivan, F.; Dowd, A.; Henry, M.; Jeppesen, P.B.; Meleady, P.; Clynes, M. (2006) 'Proteomic screening of glucose-responsive and glucose non-responsive MIN-6 beta cells reveals differential expression of proteins involved in protein folding, secretion and oxidative stress'. Proteomics, 6 . [Link] [DOI]
2006 Dowling P, O’Driscoll L, O’Sullivan F, Dowd A, Henry M, Jeppesen PB, Meleady P*, Clynes M* (2006) 'Proteomic screening of glucose-responsive and glucose non-responsive MIN-6 beta cells reveals differential expression of proteins involved in protein folding, secretion and oxidative stress'. Proteomics, 6 :6578-6587.
2006 Dowling, P; O' Driscoll, L; O' Sullivan, F; Dowd, A; Henry, M; Jeppesen, PB; Meleady, P; Clynes, M (2006) 'Proteomic screening of glucose-responsive and glucose non-responsive MIN-6 beta cells reveals differential expression of proteins involved in protein folding, secretion and oxidative stress'. Proteomics, 6 :6578-6587. [DOI]
2006 Meleady, P (2006) 'Proteomic profiling of recombinant cells from large-scale mammalian cell culture processes'. Cytotechnology, 53 (1-3). [DOI]
2003 Clynes, M; O'Connor, R; O'Driscoll, L; Daly, C; Meleady, P (2003) 'Challenges in molecular analysis for individualized cancer therapy'. Drug Discovery Today, 8 (12). [DOI]
2003 Walsh, D.*, Meleady, P.*, Power, B., Morley, S.J. and Clynes, M. (2003) 'Increased levels of the translation initiation factor, eIF4E, in differentiating epithelial lung tumour cell lines'. DIFFERENTIATION, 71 :126-134.
2003 Walsh, D; Meleady, P; Power, B; Morley, SJ; Clynes, M (2003) 'Increased levels of the translation initiation factor eIF4E in differentiating epithelial lung tumor cell lines'. Differentiation; research in biological diversity, 71 (2). [DOI]
2003 Walsh, D; Meleady, P; Power, B; Morley, SJ; Clynes, M (2003) 'Increased levels of the translation initiation factor eIF4E in differentiating epithelial lung tumor cell lines'. DIFFERENTIATION, 71 (2).
2002 Meleady, P; Clynes, M (2002) 'Bromodeoxyuridine induces integrin expression at transcriptional (alpha2 subunit) and post-transcriptional (beta1 subunit) levels, and alters the adhesive properties of two human lung tumour cell lines'. Cell communication & adhesion, 8 (1). [DOI]
2001 Meleady, P.; Clynes, M. (2001) 'Bromodeoxyuridine induces integrin expression at transcriptional (α2 subunit) and post-transcriptional (β1 subunit) levels, and alters the adhesive properties of two human lung tumour cell lines'. Cell Adhesion and Communication, 8 . [Link]
2001 Meleady, P. and Clynes, M. (2001) 'Bromodeoxyuridine increases keratin 19 protein expression at a post-transcriptional level in two human lung tumor cell lines'. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 37 :536-542.
2001 Liang, Y., Meleady, P., Cleary, I., McDonnell, S., Connolly, L. and Clynes, M. (2001) 'Selection with melphalan, or taxol, yields variants with different patterns of multidrug resistance, and integrin expression and in vitro invasiveness'. European journal of Cancer, 37 :1041-1052.
2001 Liang, Y; Meleady, P; Cleary, I; McDonnell, S; Connolly, L; Clynes, M (2001) 'Selection with melphalan or paclitaxel (Taxol) yields variants with different patterns of multidrug resistance, integrin expression and in vitro invasiveness'. European journal of cancer (Oxford, England : 1990), 37 (8). [DOI]
2001 Meleady, P; Clynes, M (2001) 'Bromodeoxyuridine increases keratin 19 protein expression at a posttranscriptional level in two human lung tumor cell lines'. In Vitro Cellular and Developmental Biology - Animal, 37 (8). 2.0.CO;2" target="_blank">[DOI]
2001 Liang, Y; Meleady, P; Cleary, I; McDonnell, S; Connolly, L; Clynes, M (2001) 'Selection with melphalan or paclitaxel (Taxol) yields variants with different patterns of multidrug resistance, integrin expression and in vitro invasiveness'. European journal of Cancer, 37 (8).
2001 Meleady, P; Clynes, M (2001) 'Bromodeoxyuridine increases keratin 19 protein expression at a posttranscriptional level in two human lung tumor cell lines'. In Vitro Cellular and Developmental Biology - Animal, 37 (8).
2001 Meleady, P; Clynes, M (2001) 'Bromodeoxyuridine induces integrin expression at transcriptional (α2 subunit) and post-transcriptional (β1 subunit) levels, and alters the adhesive properties of two human lung tumour cell lines'. Cell Communication and Adhesion, 8 (1).
2001 Meleady, P, Clynes, M (2001) 'Bromodeoxyuridine induces integrin expression at transcriptional (b2 subunit) and post-transcriptional (a1 subunit) levels, and alters the adhesive properties of two human lung tumour cell lines'. Cell Communication and Adhesion, 8 :45-59.
1999 McBride, S; Walsh, D; Meleady, P; Daly, N; Clynes, M (1999) 'Bromodeoxyuridine induces keratin protein synthesis at a posttranscriptional level in human lung tumour cell lines'. Differentiation; research in biological diversity, 64 (3). [DOI]
1999 McBride, S; Walsh, D; Meleady, P; Daly, N; Clynes, M (1999) 'Bromodeoxyuridine induces keratin protein synthesis at a posttranscriptional level in human lung tumour cell lines'. DIFFERENTIATION, 64 (3).
1999 McBride, S., Walsh, D., Meleady, P., Daly, N. and Clynes, M. (1999) 'Bromodeoxyuridine induces keratin protein expression in lung tumour cell lines at a posttranscriptional level'. DIFFERENTIATION, 64 :185-193.
1998 McBride, S., Meleady, P., Baird, A., Dinsdale, D. and Clynes, M. (1998) 'Human lung carcinoma cell line DLKP contains 3 distinct subpopulations with different growth and attachment properties'. Tumor Biology, 19 :88-103.
1998 McBride, S; Meleady, P; Baird, A; Dinsdale, D; Clynes, M (1998) 'Human lung carcinoma cell line DLKP contains 3 distinct subpopulations with different growth and attachment properties'. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 19 (2). [DOI]
1998 Daly, N.; Meleady, P.; Walsh, D.; Clynes, M. (1998) 'Regulation of keratin and integrin gene expression in cancer and drug resistance'. Cytotechnology, 27 . [Link] [DOI]
1998 McBride, S; Meleady, P; Baird, A; Dinsdale, D; Clynes, M (1998) 'Human lung carcinoma cell line DLKP contains 3 distinct subpopulations with different growth and attachment properties'. Tumor Biology, 19 (2).
1995 MELEADY, P; CLYNES, M (1995) 'GROWTH OF A HUMAN LUNG-CELL LINE IN A DEFINED SERUM-FREE MEDIUM'. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 14 (1).
1995 Meleady, P. and Clynes, M. (1995) 'Growth of a human lung cell line in a defined serum-free medium'. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 14(1) :68-70.

Review Articles

Year Publication
1998 Daly, N; Meleady, P; Walsh, D; Clynes, M (1998) Regulation of keratin and integrin gene expression in cancer and drug resistance. REV
2016 Coleman, Orla; Henry, Michael; McVey, Gerard; Clynes, Martin; Moriarty, Michael; Meleady, Paula (2016) Proteomic strategies in the search for novel pancreatic cancer biomarkers and drug targets: recent advances and clinical impact. REV [DOI]
2016 Coleman, O; Henry, M; Mcvey, G; Clynes, M; Moriarty, M; Meleady, P (2016) Proteomic strategies in the search for novel pancreatic cancer biomarkers and drug targets: recent advances and clinical impact. ABINGDON: REV [DOI]
2016 Coleman, O; Henry, M; Mcvey, G; Clynes, M; Moriarty, M; Meleady, P (2016) Proteomic strategies in the search for novel pancreatic cancer biomarkers and drug targets: recent advances and clinical impact. ABINGDON: REV [DOI]
2014 Ramasamy, P; Murphy, CC; Clynes, M; Horgan, N; Moriarty, P; Tiernan, D; Beatty, S; Kennedy, S; Meleady, P (2014) Proteomics in uveal melanoma. LONDON: REV [DOI]
2009 Jenkins, Nigel; Meleady, Paula; Tyther, Raymond; Murphy, Lisa (2009) Strategies for analysing and improving the expression and quality of recombinant proteins made in mammalian cells. REV [DOI]

Other Publication

Year Publication
2023 McDermott, MSJ; Browne, BC; Conlon, NT; O'Brien, NA; Slamon, DJ; Henry, M; Meleady, P; Clynes, M; Dowling, P; Crown, J; O'Donovan, N (2023) Correction: PP2A inhibition overcomes acquired resistance to HER2 targeted therapy. [DOI]
2018 Murphy, S.; Zweyer, M.; Henry, M.; Meleady, P.; Mundegar, R.R.; Swandulla, D.; Ohlendieck, K. (2018) Subproteomic profiling of sarcolemma from dystrophic mdx-4cv skeletal muscle. [Link] [DOI]
2017 McCarthy, C; Dunlea, DM; Saldova, R; Henry, M; Meleady, P; McElvaney, OJ; Marsh, B; Rudd, PM; Reeves, EP; McElvaney, NG (2017) Glycosylation Repurposes Alpha-1 Antitrypsin for Resolution of Community-acquired Pneumonia. [DOI]
2010 Doolan, P; Meleady, P; Barron, N; Henry, M; Gallagher, R; Gammell, P; Melville, M; Sinacore, M; McCarthy, K; Leonard, M; Charlebois, T; Clynes, M (2010) Microarray and proteomics expression profiling identifies several candidates, including the valosin-containing protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines. [DOI]
2015 Lopes-Rodrigues, Vanessa; Di Luca, Alessio; Sousa, Diana; Seca, Hugo; Meleady, Paula; Henry, Michael; Lima, Raquel T.; O'Connor, Robert; Helena Vasconcelos, M. (2015) P-gp-overexpressing MDR cells shed larger extracellular vesicles than their drug-sensitive counterparts. [DOI]
2013 White, M.; Cox, S.; Hayes, E.; Bergin, D.; Keenan, J.; Meleady, P.; Henry, M.; Clynes, M.; McElvaney, N. G.; Reeves, E. P. (2013) Altered Lipid Raft Structure and Membrane Cholesterol Content as a Potential Cause for Dysregulated Neutrophil Activity in Cystic Fibrosis.
2013 Bergin, D. A.; Henry, M.; Meleady, P.; Clynes, M.; Reeves, E. P.; McElvaney, N. G. (2013) Identification of Novel Truncated Alpha-1 Antitrypsin Protein in a Q0bolton Deficient Patient.
2013 O'Brien, M. E.; McCarthy, C.; Henry, M.; Bergin, D. A.; Meleady, P.; Reeves, E. P.; Clynes, M.; McElvaney, N. G. (2013) Alpha-1 Antitrypsin Binds Complement C3: A Novel Immune Regulatory Role.
2012 McDermott, M. S.; Browne, B. C.; O'Brien, N. A.; Slamon, D. J.; Henry, M.; Meleady, P.; Clynes, M.; Dowling, P.; Crown, J.; O'Donovan, N. (2012) PP2A-a Novel Target for the Treatment of Lapatinib-resistant Breast Cancer.
2009 Bergin, D. A.; Reeves, E. P.; Henry, M.; Meleady, P.; Clynes, M.; O'Neill, S. J.; McElvaney, N. G. (2009) The Neutrophil and alpha-1 Antitrypsin: Relationship and Regulation.
2007 Bryan, William; Dowd, Andrew; Joyce, Helena; Meleady, Paula; Clynes, Martin (2007) Proteomic analysis of DLKP and its subpopulations: DLKP-SQ, DLKP-I and DLKP-M and interpretations of altered invasion rates observed in these clones.
2007 Maurya, Priyanka; Meleady, Paula; Dowling, Paul; Clynes, Martin (2007) Differential protein profiling of secreted proteins from human cancer cell lines by surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI).
2007 Bryan, William; Meleady, Paula; Dowd, Andrew; Dowling, Paul; Clynes, Martin (2007) Proteomic analysis antiproliferative effect of 5-fluorouracil on normal and cancer epithelial cells of the lung.
2005 Dowling, P.; O'Driscoll, L.; Dowd, A.; Meleady, P.; Clynes, M. (2005) DIGE analyses indicates phenotypic changes between glucose-responsive and glucose-non-responsive MIN-6 beta cells.
2005 Meleady, P.; Dowd, A.; Dowling, P.; Henry, M.; O'Callaghan, M.; Clynes, M. (2005) Two-dimensional difference gel electrophoresis (DIGE) of a bromodeoxyuridine-treated human lung carcinoma cell line.
2005 Murphy, L.; Keenan, J.; Meleady, P.; Clynes, M. (2005) Detection of potential drug-resistant markers in lung cancer.
2022 Murphy, M. P.; Zieger, M.; Hunt, D. J. L.; Henry, M.; Meleady, P.; Mueller, C.; McElvaney, N. G.; Reeves, E. P. (2022) Degradation of Elastin in Emphysema Is Exacerbated by Peptidyl Arginine Deiminase Activity.
2021 Dunphy, Katie; Bazou, Despina; Henry, Michael; Meleady, Paula; Dowling, Paul; O'Gorman, Peter (2021) Characterisation of the Tumour Proteome in Primary Extramedullary Multiple Myeloma Identifies Key Proteins Associated with Transendothelial Migration. [DOI]
2021 Dunphy, Katie; Dowling, Paul; Miettinen, Juho J.; Heckman, Caroline A.; Meleady, Paula; Henry, Michael; Bazou, Despina; O'Gorman, Peter (2021) Phosphoproteomic Analysis of Primary Myeloma Patient Samples Identifies Distinct Phosphorylation Signatures Correlating with Chemo-Sensitivity Profiles in an Ex Vivo Drug Sensitivity Testing Platform. [DOI]
2018 McEnery, T.; Coleman, O.; Hawkins, P.; White, M.; Lacey, N.; Meleady, P.; Reeves, E. P.; McElvaney, N. G. (2018) The Circulating Neutrophil Proteome Is Altered in Alpha-1 Antitrypsin Deficiency and Is Modified by Intravenous Augmentation Therapy.
2010 Dowling P, Meleady P, Henry M, Clynes M (2010) Recent advances in clinical proteomics using mass spectrometry.
2009 Jenkins N, Meleady P, Tyther R, Murphy L. (2009) Strategies for analysing and improving the expression and quality of recombinant proteins made in mammalian cells.
2007 Maurya P, Meleady P, Dowling P, Clynes M (2007) Proteomic Approaches For Serum Biomarker Discovery In Cancer.
2007 Paula Meleady (2007) Proteomic profiling of recombinant cells from large-scale mammalian cell culture processes.
2003 Clynes M, O'Connor R, O'Driscoll L, Daly C, Meleady P. (2003) Challenges in molecular analysis for individualized cancer therapy.
1998 Daly, N., Meleady, P., Walsh, D. and Clynes, M. (1998) Regulation of keratin and integrin gene expression in cancer and drug resistance.
1997 Dr. Paula Meleady (1997) Serum-free medium and differentiation studies in cultured cell lines. Dublin City University:
2018 McCarthy, C.; Dunlea, D.M.; Saldova, R.; Henry, M.; Meleady, P.; McElvaney, O.J.; Marsh, B.; Rudd, P.M.; Reeves, E.P.; McElvaney, N.G. (2018) Glycosylation repurposes alpha-1 antitrypsin for resolution of community-acquired pneumonia. [Link] [DOI]
2017 McEnery, T.; Hunt, D. J. L.; White, M. M.; Henry, M.; Meleady, P.; Reeves, E.; McElvaney, N. G. (2017) Neutrophil Membrane Proteomics In Alpha-1 Antitrypsin Deficiency.
2017 Murphy, S.; Zweyer, M.; Dowling, P.; Henry, M.; Meleady, P.; Swandulla, D.; Ohlendieck, K. (2017) Proteomic identification of novel brain and serum biomarkers linked to the pathophysiology of Duchenne muscular dystrophy. [DOI]
2016 Meleady, Paula; Henry, Michael; Power, Martin; Prashant, Prashant; Clynes, Martin (2016) Characterisation of the phosphoproteome to understand and improve bioprocess-relevant phenotypes in recombinant Chinese hamster ovary cells. [DOI]
2014 Ramasamy, Pathma; Henry, Michael; Clynes, Martin; Murphy, Conor; Larkin, Anne-Marie; Beatty, Stephen; Moriarty, Paul; Kennedy, Susan; Meleady, Paula (2014) Quantitative Label-free LC-MS Proteomic Analysis of Uveal Melanoma Identifies Proteins Associated with Metastasis.

Conference Publication

Year Publication
1995 OTOOLE, A; MELEADY, P; CLYNES, M (1995) 1995 ICHEME RESEARCH EVENT - FIRST EUROPEAN CONFERENCE FOR YOUNG RESEARCHERS IN CHEMICAL ENGINEERING, VOLS 1 AND 2 AGITATION RESISTANCE OF CHINESE HAMSTER OVARY CELLS
2012 Kumar, Niraj; Sanchez, Noelia; Gammell, Patrick; Dowling, Patrick; Henry, M.; Meleady, P.; Barron, Niall; Clynes, Martin (2012) PROCEEDINGS OF THE 21ST ANNUAL MEETING OF THE EUROPEAN SOCIETY FOR ANIMAL CELL TECHNOLOGY (ESACT), 2009 Proteomic Profiling of Temperature-Shifted CHO Cells to Identify Genes that Impact on Both Cell Growth and Recombinant Protein Productivity in Suspension Culture [DOI]
2010 Melville, Mark; Sinacore, Martin S.; Di Nino, Dana; McCarthy, Kevin; Anderson, Karin; Kopycinski, Kathleen; Lee, Gene W.; Max, Steven; Gammell, Patrick; Doolan, Padraig; Meleady, Paula; Barron, Niall; Leonard, Mark; Clynes, Martin; Charlebois, Tim (2010) CELLS AND CULTURE Differential Expression Profiling of Industrially Relevant CHO Cell Phenotypes Using a Proprietary CHO-Specific Microarray and Proteomics Technology Platforms [DOI]
1995 Meleady, P.; Clynes, M. (1995) Growth of a human lung cell line in a defined serum-free medium [Link]

Editorial

Year Publication
2003 Clynes, M; O'Connor, R; O'Driscoll, L; Daly, C; Meleady, P (2003) Challenges in molecular analysis for individualized cancer therapy. ED
2017 Meleady, Paula (2017) Heterologous Protein Production in CHO Cells Methods and Protocols Preface. ED
Certain data included herein are derived from the © Web of Science (2024) of Clarivate. All rights reserved.

Committees

Committee Function From / To
Academic Council, DCU 01/10/2019 -
Faculty Research Commitee 01/03/2015 -

Research Interests

proteomics, clinical proteomics, mass spectrometry, bioprocessing, biopharmaceuticals, uveal melanoma, pancreatic cancer

Research Projects

Title Role Description Start date End date
Proteomics and post-translational regulatory networks - ITN eCHO network Principal Supervisor of Early Stage Researcher 01/09/2015 30/09/2018
Regulating Expression of Specific Gene Products in Mammalian Cells to Ensure Recombinant Protein Product Quality. Innovation Partnership with Eli Lilly Ireland. DCU PI 01/02/2014 31/01/2016
A pincer movement on PDAC: combining proteomics and spectralomics for biological marker discovery (Esen Efeoglu) DCU PI 01/10/2021 30/09/2023
Proteomic Strategies to Identify Process Changes that can Affect Product Quality of Biopharmaceutical Proteins from CHO Cells DCU PI 15/02/2022 14/02/2024
Deciphering the role of ubiquitination in regulating the productivity of biotherapeutics from recombinant Chinese hamster ovary cell lines. DCU PI 01/12/2020 30/11/2024
Mapping the molecular basis for productivity in industrially relevant CHO cell lines - Laura Bryan DCU PI 04/01/2017 03/01/2021

Current Postgraduate Students

Student Name Degree Supervision
Sideri ,Christiana-Kondylo PhD-track Supervisor
Ryan ,David PhD-track Supervisor