Christine Loscher
Prof.
Professor Christine Loscher completed her PhD
in Immunology at NUI, Maynooth in 2000 and was awarded a Health Research Board
Fellowship to pursue her postdoctoral studies at Trinity College Dublin. In
2003 she moved to the Institute of Molecular Medicine at St James Hospital to
continue her research and then was appointed to a permanent academic position
at Dublin City University in 2005. She leads the Immunomodulation Research
Group at DCU which has a focus on translating how modulation of the immune
response has health benefits. Her focus includes discovering new
anti-inflammatory/anti-allergic compounds and ingredients that can be used in
the pharma and food industry. She is a Principal Investigator in the Food for
Health Ireland Technology Centre and served on the Scientific Advisory Council
at Kerry Foods from 2015 to 2017. She has developed significant expertise in
commercial research and industry engagement and has secured over €5.5M in
external funding for her research. In 2014 she was named in Silicon Republics top
100 Women in STEM and in 2015 she was a speaker at InspireFest. In 2016 she
delivered a TEDx talk to communicate her views on the Future of Food and in
2018 she was included in Silicon Republic’s “22 high-flying scientists making the world a
better place in 2019”. She is currently the Associate Dean for Research in the
Faculty of Science & Health at DCU. In
2020 she was promoted to Full Professor of Immunology and established the DCU
Covid-19 Research & Innovation Hub which currently has 16 funded projects
aimed at novel solutions in the fight against Covid-19.
https://www.youtube.com/watch?v=XFOk-dlPafQ
https://www.youtube.com/watch?v=XFOk-dlPafQ
Book Chapter
Peer Reviewed Journal
| Year | Publication | |
|---|---|---|
| 2015 | Collins L.;DeCourcey J.;Rochfort K.;Kristek M.;Loscher C. (2015) 'A role for syntaxin 3 in the secretion of IL-6 from dendritic cells following activation of toll-like receptors'. Frontiers in Immunology, 6 (JAN). [DOI] | |
| 2013 | Morine M.;Toomey S.;McGillicuddy F.;Reynolds C.;Power K.;Browne J.;Loscher C.;Mills K.;Roche H. (2013) 'Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice'. Journal of Nutritional Biochemistry, 24 (5):788-795. [DOI] | |
| 2012 | Bruneau J.;Stack E.;O'Kennedy R.;Loscher C. (2012) 'Aflatoxins B 1, B 2 and G 1 modulate cytokine secretion and cell surface marker expression in J774A.1 murine macrophages'. Toxicology in Vitro, 26 (5):686-693. [DOI] | |
| 2011 | McEntee G.;Minguzzi S.;O'Brien K.;Larbi N.;Loscher C.;O'́faǵaín C.;Parle-McDermott A. (2011) 'The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional'. Proceedings of the National Academy of Sciences of the United States of America, 108 (37):15157-15162. [DOI] | |
| 2011 | Ryan A.;Lynch M.;Smith S.;Amu S.;Nel H.;McCoy C.;Dowling J.;Draper E.;O'Reilly V.;McCarthy C.;O'Brien J.;Eidhin D.;O'Connell M.;Keogh B.;Morton C.;Rogers T.;Fallon P.;O'Neill L.;Kelleher D.;Loscher C. (2011) 'A role for TLR4 in clostridium difficile infection and the recognition of surface layer proteins'. PLoS Pathogens, 7 (6). [DOI] | |
| 2015 | Kristek M.;Collins L.;DeCourcey J.;McEvoy F.;Loscher C. (2015) 'Soluble factors from colonic epithelial cells contribute to gut homeostasis by modulating macrophage phenotype'. Innate immunity, 21 (4):358-369. [DOI] | |
| 2015 | Negm O.;Hamed M.;Dilnot E.;Shone C.;Marszalowska I.;Lynch M.;Loscher C.;Edwards L.;Tighe P.;Wilcox M.;Monaghan T. (2015) 'Profiling humoral immune responses to Clostridium difficile-specific antigens by protein microarray analysis'. Clinical And Vaccine Immunology, 22 (9):1033-1039. [DOI] | |
| 2015 | Webb A.;Gerek Z.;Morgan C.;Walsh T.;Loscher C.;Edwards S.;O'Connell M. (2015) 'Adaptive evolution as a predictor of species-specific innate immune response'. Molecular Biology and Evolution, 32 (7):1717-1729. [DOI] | |
| 2014 | Draper E.;DeCourcey J.;Higgins S.;Canavan M.;McEvoy F.;Lynch M.;Keogh B.;Reynolds C.;Roche H.;Mills K.;Loscher C. (2014) 'Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses'. Journal of Nutritional Biochemistry, 25 (7):741-749. [DOI] | |
| 2014 | Collins LE, Lynch M, Marszalowska I, Kristek M, Rochfort K, O’Connell M, Windle H, Kelleher D and Loscher CE. (2014) 'Surface Layer Proteins Isolated from Clostridium difficile Induce Clearance Responses in Macrophages. '. Microbes and Infection, Available online 19 February 2014 PMID: 24560642 . | |
| 2014 | Haberlin G, McCarthy C, Doran R, Loscher CE and Guiry PJ. (2014) 'Synthesis and Biological Evaluation of 1,3- and 1,4-Disubstituted Benzo-type Lipoxin A4 Analogues. '. Organic and Biomolecular Chemistry, Under review Organic & Biomolecular Chemistry. Manuscript number OB-ART-09-2013-041948 . | |
| 2014 | Kennedy E.;Hakimjavadi R.;Greene C.;Mooney C.;Fitzpatrick E.;Collins L.;Loscher C.;Guha S.;Morrow D.;Redmond E.;Cahill P. (2014) 'Embryonic rat vascular smooth muscle cells revisited - A model for neonatal, neointimal SMC or differentiated vascular stem cells?'. Vascular Cell, 6 (1). [DOI] | |
| 2014 | Canavan M.;McCarthy C.;Larbi N.;Dowling J.;Collins L.;O'Sullivan F.;Hurley G.;Murphy C.;Quinlan A.;Moloney G.;Darby T.;Macsharry J.;Kagechika H.;Moynagh P.;Melgar S.;Loscher C. (2014) 'Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-κBp50'. Innate immunity, 20 (7):675-687. [DOI] | |
| 2014 | Korzeniowska B.;Woolley R.;DeCourcey J.;Wencel D.;Loscher C.;McDonagh C. (2014) 'Intracellular pH-sensing using core/shell silica nanoparticles'. Journal of Biomedical Nanotechnology, 10 (7):1336-1345. [DOI] | |
| 2014 | Kristek M.;Loscher C. (2014) 'The emerging roles of intestinal macrophages in sickness and in health'. Periodicum Biologorum, 116 (2):125-129. | |
| 2014 | Haberlin G.;McCarthy C.;Doran R.;Loscher C.;Guiry P. (2014) 'Asymmetric synthesis and biological evaluation of 1,3- and 1,4-disubstituted benzo-type lipoxin A4analogues'. Tetrahedron, (38):6859-6869. [DOI] | |
| 2014 | Collins L.;Lynch M.;Marszalowska I.;Kristek M.;Rochfort K.;O'Connell M.;Windle H.;Kelleher D.;Loscher C. (2014) 'Surface layer proteins isolated from Clostridium difficile induce clearance responses in macrophages'. Microbes and Infection, 16 (5):391-400. [DOI] | |
| 2013 | Rahman A.;DeCourcey J.;Larbi N.;Loughran S.;Walls D.;Loscher C. (2013) 'Syntaxin-4 is essential for IgE secretion by plasma cells'. Biochemical and Biophysical Research Communications, 440 (1):163-167. [DOI] | |
| 2013 | Rahman A, DeCourcey J, Ben Larbi N, Loughran ST, Walls D and Loscher CE. (2013) 'Syntaxin-4 is Essential for IgE Secretion by Plasma Cells. '. Biochemical and Biophysical Research Communications, doi:pii: S0006-291X(13)01539-8. 10.1016/j.bbrc.2013.09.058. [Epub ahead of print]PMID: 24055037 . | |
| 2013 | Dowling J.;McCoy C.;Doyle S.;BenLarbi N.;Canavan M.;O'Neill L.;Loscher C. (2013) 'Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14'. Journal of Nutritional Biochemistry, 24 (5):920-928. [DOI] | |
| 2012 | Morgan CC, Shakya K, Webb A, Walsh TA, Lynch M, Loscher CE, Ruskin HJ, O'Connell MJ. (2012) 'Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions. '. BMC Evolutionary Biology, 12(1):114. PMID: 22788692 . | |
| 2012 | Bruneau JC, Stack E, O'Kennedy R, Loscher CE. (2012) 'Aflatoxins B(1), B(2) and G(1) modulate cytokine secretion and cell surface marker expression in J774A.1 murine macrophages'. Toxicology in Vitro, 26(5):686-93. PMID:22445859 . | |
| 2011 | Ryan A, Lynch M, Smith SM, Amu S, Nel HJ, McCoy CE, Dowling JK, Draper E, O'Reilly V, McCarthy C, O'Brien J, Ní Eidhin D, O'Connell MJ, Keogh B, Morton CO, Rogers TR, Fallon PG, O'Neill LA, Kelleher D, Loscher CE. (2011) 'A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins'. PLoS Pathogens, 7(6):e1002076. PMID: 21738466 . | |
| 2011 | Draper E.;Reynolds C.;Canavan M.;Mills K.;Loscher C.;Roche H. (2011) 'Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ'. Journal of Nutritional Biochemistry, 22 (8):784-790. [DOI] | |
| 2010 | Duffy C.;Maderna P.;McCarthy C.;Loscher C.;Godson C.;Guiry P. (2010) 'Synthesis and biological evaluation of pyridine-containing lipoxin A4 analogues'. ChemMedChem, 5 (4):517-522. [DOI] | |
| 2009 | Hamilton CM, Dowling DJ, Loscher CE, Morphew RM, Brophy PM, O'Neill SM. (2009) 'The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function. '. Infection and Immunity, 77(6):2488-98. PMID: 19332532 . | |
| 2009 | de Roos B, Rungapamestry V, Ross K, Rucklidge G, Reid M, Duncan G, Horgan G, Toomey S, Browne J, Loscher CE, Mills KH and Roche HM. (2009) 'Attenuation of inflammation and oxidative stress related pathways maintain insulin sensitivity in obese type I interleukin 1 receptor knockout mice on a high fat diet. '. Proteomics, 9(12):3244-56 PMID 19562798 . | |
| 2009 | Reynolds C.;Draper E.;Keogh B.;Rahman A.;Moloney A.;Mills K.;Loscher C.;Roche H. (2009) 'A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARγ-mediated suppression of toll-like receptor 4'. Journal of Nutrition, 139 (12):2351-2357. [DOI] | |
| 2008 | Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME, Garlanda C, Mantovani A, O'Neill LA, Mills KH, Lynch MA. (2008) 'IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8. '. Journal of Neurochemistry, 105(5):1960-9 . | |
| 2008 | Reynolds CM, Loscher CE, Moloney AP, Roche HM. (2008) (2008) 'Cis-9, trans-11-conjugated linoleic acid but not its precursor trans-vaccenic acid attenuate inflammatory markers in the human colonic epithelial cell line Caco-2. '. British Journal of Nutrition, 100(1):13-17 . | |
| 2007 | Moloney F., Toomey S., Noone E., Nugent A., Allan B., Loscher CE and Roche HM (2007) 'Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue'. Diabetes, 56 :574-582. | |
| 2005 | De Roos B, Rucklidge G, Reid M, Pickard K, Navarro MA, Arbones-Mainar JM, Guzman-Garcia MA, Osada J., Browne J., Loscher CE. and Roche HM. (2005) 'Divergent mechanisms of cis9, trans11- and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach'. 19 :1746-1758. | |
| 2005 | Loscher CE, Draper E, Leavy O, Mills KH and Roche HM. (2005) 'Polyunsaturated fatty acids suppress NFкB activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction'. Journal of Immunology, 175 (8): 4990-8. . | |
| 2005 | Armstrong, M.E., Lavelle, E.C., Loscher, C.E., Lynch, M.A. and Mills, K.H. (2005) 'Pro-inflammatory responses in the murine brain following intranasal delivery of cholera toxin: implications for the use of AB toxins as adjuvants in nasal vaccines'. JOURNAL OF INFECTIOUS DISEASE, 192 :1628-1633. | |
| 2003 | Loscher, C.E., Mills, K.H. and Lynch, M.A. (2003) 'Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type ƒ¹ receptor'. Journal of Neuroimmunology, 137 :117-124. | |
| 2003 | Kelly, Á., Vereker, E., Nolan Y, Brady, M., Barry, C., Loscher, C.E., Mills, K.H and Lynch, M.A. (2003) 'Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta on long-term potentiation in rat dentate gyrus'. Journal of Biological Chemistry, 278 :19453-19562. | |
| 2003 | 6) Loscher, C.E.,* Armstrong, M.E.,* Lynch, M.A. and Mills, K.H. (2003) 'IL-1beta dependent neurological side effects of the whole cell pertussis vaccine: a role for IL-1-associated signaling components in vaccine reactogenicity'. Journal of Neuroimmunology, 136 :25-33. | |
| 2001 | Donnelly S., Loscher C.E., Lynch M.A. and Mills K.H. (2001) 'Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination'. Infection and Immunity, 69 :4217-4223. | |
| 2000 | Loscher C.E., Donnelly S., Lynch M.A. and Mills K.H. (2000) 'Induction of inflammatory cytokines in the brain following respiratory infection with Bordetella pertussis'. Journal of Neuroimmunology, 102 :172-181. | |
| 2000 | Loscher C.E., Donnelly S., Mills K.H. and Lynch, M.A. (2000) 'Interleukin-1-beta-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine'. Journal of Neuroimmunology, 111 :68-76. | |
| 1999 | Donnelly S., Loscher C.E., Mills K.H. and Lynch, M.A. (1999) 'Glycerol-induced seizure: involvement of IL-1beta and glutamate'. NeuroReport, 10 :1821-1825. | |
| 1998 | Loscher C.E., Donnelly S., McBennet S., Lynch M.A. and Mills K.H. (1998) 'Proinflammatory cytokines in the adverse systemic and neurologic effects associated with parenteral injection of a whole cell pertussis vaccine'. ANNALS OF THE NEW YORK ACADEMY OF SCIENCE, 856 :274-277. | |
| 1997 | Kelly, J.A., Loscher, C.E., Gallagher, S. and O’Connor, B. (1997) 'Degradation of pyroglutamyl-phenylalanyl-proline amide by a pyroglutamyl aminopeptidase purified from membrane fractions of bovine brain'. Biochemical Society Transactions, 1 . |
Other Journal
Conference Contribution
Review Articles
| Year | Publication | |
|---|---|---|
| 2015 | Collins L.;DeCourcey J.;di Luca M.;Rochfort K.;Loscher C. (2015) An emerging role for SNARE proteins in dendritic cell function. REV [DOI] |
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