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Nicholas Dunne

PROF

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Professor Nicholas Dunne is the Chair of Mechanical and Manufacturing Engineering in the School of Mechanical and Manufacturing, the Founding Executive Director of Biodesign Europe and the Executive Director of the Medical Engineering Research Centre Engineering (MedEng) at DCU. Professor Dunne is also a Honorary Research Professor of Biomaterials Engineering at the School of Pharmacy at the Queen's University of Belfast (QUB), an Adjunct Professor of the School of Mechanical Engineering at Trinity College Dublin and a Principal Investigator in the Trinity Centre for Bioengineering.

Prior to his appointment at DCU, he was the Professor of Biomaterials Engineering at QUB He has also held Joint-Directorship positions in the Advanced Materials and Processes Research Cluster and the Polymer Processing Research Centre at QUB.

Professor Dunne’s research programme lies at the interface of materials science, engineering and biology. He leads a multidisciplinary group working at the host/biomaterial interface that has played a leading role in the development of biomaterials that simulate an efficacious drug delivery or therapeutic response. This work spans fundamental mechanisms at the host/material interface as well as translational research to target non-union bone defects, bone metastases and chronic wounds. This research has been developed via a strong, interdisciplinary programme complemented with over-arching institutional and industrial collaborations.

Internationally he is recognised as an authority on biomaterials for orthopaedic applications, having been awarded an Orthopaedic Research Society/British Orthopaedic Research Society Fellowship (2008) and the RAEng/Leverhulme Trust Senior Research Fellow Award (2010). His work has been supported continuously by RCUK, EU and Charity funding organisations and also attracts significant interest from industrial partners. To date, he has secured ≈€19M PI research funding (and €18.5M as CI) - from the EU Commissio, Engineering and Physical Sciences Research Council, Science Foundation Ireland, Medical Research Council, Invest NI, Irish Research Council, Innovate UK and The Royal Academy of Engineering and several major multinational medical device companies.

He has authored +250 peer-reviewed journal publications and delivered +500 research presentations at national and international biomaterials and biomechanics conferences He is a Journal Editor of Biomaterials Advances and Editorial Board Member of Regenerative Biomaterials, Royal Society of Chemistry - Biomaterials Science, Journal of Materials Science: Materials in Medicine, International Journal of Biomaterials and Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine.

He is also highly passionate about engaging new and young researchers on matters that are important to their research career and professional development. This enthusiasm and motivation have been hardened during his time as President of Northern Ireland Bioengineering Society (2008-2015) and Spokesperson of the Young Scientist Fora of the European Society for Biomaterials (2010-2014) and UK Society for Biomaterials (2011-2015). He was the VP and Secretary of the Executive Organising Committee of the 11th World Biomaterials Congress (Glasgow, 2020) and also on the Executive Organising Committee member of the 8th World Biomechanics Congress (Dublin, 2018), as well as the President of the Royal Academy of Medicine in Ireland – Section of Bioengineering (2019-2023). He is a member of the European Society for Biomaterials Council (2019) and currently holds the position of Council Secretary.

Book Chapter

Year Publication
2021 Dunne, N.; Tzagiollari, A.; Sahebalzamani, M.; Dunne, T.J. (2021) 'Acrylic cements for bone fixation in joint replacement' In: Joint Replacement Technology. [Link] [DOI]
2021 Jena L, Dunne NJ, McCarthy HO. (2021) 'Nanoparticles beyond the blood-brain barrier for glioblastoma' In: Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies. USA : Academic Press. [DOI]
2019 Chambers P, McCarthy HO, Dunne NJ. (2019) 'Emerging areas of bone repair materials: nucleic acid therapy and drug delivery' In: Bone Repair Biomaterials: Regeneration and Clinical Applications. UK : Woodhead Publishing. [DOI]
2018 Cole, G; Dunne, NJ; McCarthy, HO (2018) 'Microneedles for Gene Therapy: Overcoming Extracellular and Intracellular Barriers' In: MICRONEEDLES FOR DRUG AND VACCINE DELIVERY AND PATIENT MONITORING. CHICHESTER : JOHN WILEY & SONS LTD.
2018 Cole G, Dunne NJ, McCarthy HO. (2018) 'Microneedles for Gene Therapy: Overcoming Extracellular and Intracellular Barriers' In: Microneedles for Drug and Vaccine Delivery and Patient Monitoring. USA : Wiley & Sons. [DOI]
2018 Pentlavalli S, McCarthy HO, Dunne NJ. (2018) 'Hydrogels for Bone Regeneration' In: Hydrogels: Design, Synthesis and Application in Drug Delivery and Regenerative Medicine. USA : CRC Press.
2017 Pentlavalli S, McCarthy HO, Dunne NJ. (2017) 'The Mechanical Properties of the Scaffolds Reinforced by Fibres or Tubes for Tissue Repair' In: Tissue Repair. Singapore : Springer. [DOI]
2016 Cunningham E, Walker G, Buchanan F, Dunne N. (2016) 'Bio-inspired calcium phosphate materials for hard-tissue repair' In: Biomineralization and Biomaterials. UK : Woodhead Publishing. [DOI]
2014 Dunne N, Clements J, Wang JS. (2014) 'Acrylic cements for bone fixation in joint replacement' In: Joint Replacement Technology. Singapore : Woodhead Publishing. [DOI]
2014 O’Hara R, Buchanan F, Dunne N. (2014) 'Injectable calcium phosphate cements for spinal bone repair' In: Biomaterials for Bone Regeneration. UK : Woodhead Publishing. [DOI]
2013 Dunne N, Ormsby R, Mitchell CA. (2013) 'Carbon nanotubes in acrylic bone cement' In: Biologically Responsive Biomaterials for Tissue Engineering. New York : Springer. [DOI]
2011 Dunne N, Mitchell C. (2011) 'Biomedical/bioengineering applications of carbon nanotube-based nanocomposites' In: Polymer–Carbon Nanotube Composites: Preparation, Properties and Applications. UK : Woodhead Publishing. https://doi.org/10.1533/9780857091390.3.676
2011 Dunne N, Ormsby RW. (2011) 'MWCNT Used in Orthopaedic Bone Cements' In: Carbon Nanotubes-Growth and Applications. UK : InTech. [DOI]
2008 Dunne NJ. (2008) 'Mechanical properties of bone cements' In: Orthopaedic Bone Cements. UK : Woodhead Publishing. [DOI]
2008 Wang JS, Dunne NJ. (2008) 'Bone Cement Fixation: Acrylic Cements' In: Joint Replacement Technology: New Developments. UK : Woodhead Publishing. [DOI]

Review Articles

Year Publication
2020 de Armentia, SL; del Real, JC; Paz, E; Dunne, N (2020) Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration. BASEL: REV [DOI]
2020 Bi X.; Liu B.; Mao Z.; Wang C.; Dunne N.; Fan Y.; Li X. (2020) Applications of materials for dural reconstruction in pre-clinical and clinical studies: Advantages and drawbacks, efficacy, and selections. REV [DOI]
2020 Juncos Bombin A.D.; Dunne N.J.; McCarthy H.O. (2020) Electrospinning of natural polymers for the production of nanofibres for wound healing applications. REV [DOI]
2020 Levingstone, TJ; Herbaj, S; Redmond, J; McCarthy, HO; Dunne, NJ (2020) Calcium Phosphate Nanoparticles-Based Systems for RNAi Delivery: Applications in Bone Tissue Regeneration. BASEL: REV [DOI]
2019 Pei B.; Wang W.; Dunne N.; Li X. (2019) Applications of carbon nanotubes in bone tissue regeneration and engineering: Superiority, concerns, current advancements, and prospects. REV [DOI]
2019 Levingstone T.; Herbaj S.; Dunne N. (2019) Calcium phosphate nanoparticles for therapeutic applications in bone regeneration. REV [DOI]

Peer Reviewed Journal

Year Publication
2023 Acheson, J.G.; McFerran, A.; Xu, D.; Ziminska, M.; Goel, S.; Lennon, A.B.; Dunne, N.; Hamilton, A.R. (2023) 'Hydrated behavior of multilayer polyelectrolyte-nanoclay coatings on porous materials and demonstration of shape memory effect'. Surface and Coatings Technology, 458 . [Link] [DOI]
2023 Mondal, S.; MacManus, D.B.; Bonatti, A.F.; De Maria, C.; Dalgarno, K.; Chatzinikolaidou, M.; De Acutis, A.; Vozzi, G.; Fiorilli, S.; Vitale-Brovarone, C.; Dunne, N. (2023) 'A computational analysis of a novel therapeutic approach combining an advanced medicinal therapeutic device and a fracture fixation assembly for the treatment of osteoporotic fractures: Effects of physiological loading, interface conditions, and fracture fixation materials'. Medical Engineering and Physics, 114 . [Link] [DOI]
2022 Sargioti, N; Levingstone, TJ; O'Cearbhaill, ED; McCarthy, HO; Dunne, NJ (2022) 'Metallic Microneedles for Transdermal Drug Delivery: Applications, Fabrication Techniques and the Effect of Geometrical Characteristics'. Bioengineering (Basel, Switzerland), 10 (1). [DOI]
2022 Bombin, ADJ; Dunne, N; McCarthy, HO (2022) 'Delivery of a peptide/microRNA blend via electrospun antimicrobial nanofibres for wound repair'. Acta Biomaterialia, . [DOI]
2022 Munir, M; Kett, VL; Dunne, NJ; McCarthy, HO (2022) 'Development of a Spray-Dried Formulation of Peptide-Dna Nanoparticles into a Dry Powder for Pulmonary Delivery Using Factorial Design'. Pharmaceutical Research, . [DOI]
2022 Saha, C; Bojdo, J; Dunne, NJ; Duary, RK; Buckley, N; McCarthy, HO (2022) 'Nucleic acid vaccination strategies for ovarian cancer'. Frontiers In Bioengineering And Biotechnology, 10 . [DOI]
2022 Al-Kharusi, G; Dunne, NJ; Little, S; Levingstone, TJ (2022) 'The Role of Machine Learning and Design of Experiments in the Advancement of Biomaterial and Tissue Engineering Research'. Bioengineering (Basel, Switzerland), 9 (10). [DOI]
2022 Banche-Niclot, F; Corvaglia, I; Cavalera, C; Boggio, E; Gigliotti, CL; Dianzani, U; Tzagiollari, A; Dunne, N; Manca, A; Fiorilli, S; Vitale-Brovarone, C (2022) 'Optimization of an Injectable, Resorbable, Bioactive Cement Able to Release the Anti-Osteoclastogenic Biomolecule ICOS-Fc for the Treatment of Osteoporotic Vertebral Compression Fractures'. Biomolecules, 13 (1). [DOI]
2022 Chen, J; Cao, G; Li, L; Cai, Q; Dunne, N; Li, X (2022) 'Modification of polyether ether ketone for the repairing of bone defects'. Biomedical Materials (Bristol), . [DOI]
2022 Mulholland EJ, McErlean EM, Dunne NJ, McCarthy HO. (2022) 'A Peptide/MicroRNA-31 nanomedicine within an electrospun biomaterial designed to regenerate wounds in vivo'. Acta Biomaterialia, 138 :285-300. [DOI]
2022 Tzagiollari, A; McCarthy, HO; Levingstone, TJ; Dunne, NJ (2022) 'Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of Bone'. Bioengineering (Basel, Switzerland), 9 (6). [DOI]
2022 Redmond, J; McCarthy, HO; Buchanan, P; Levingstone, TJ; Dunne, NJ (2022) 'Development and characterisation of 3D collagen-gelatin based scaffolds for breast cancer research'. Biomaterials advances, 142 . [DOI]
2022 Sahebalzamani, M; Ziminska, M; McCarthy, HO; Levingstone, TJ; Dunne, NJ; Hamilton, AR (2022) 'Advancing bone tissue engineering one layer at a time: a layer-by-layer assembly approach to 3D bone scaffold materials'. Biomaterials Science, . [DOI]
2021 de Armentia, SL; Fernández-Villamarín, S; Ballesteros, Y; Del Real, JC; Dunne, N; Paz, E (2021) '3D Printing of a Graphene-Modified Photopolymer Using Stereolithography for Biomedical Applications: A Study of the Polymerization Reaction'. International journal of bioprinting, 8 (1). [DOI]
2021 McGauran, Thomas; Harris, Matt; Dunne, Nicholas; Smyth, Beatrice M.; Cunningham, Eoin (2021) 'Production of Feather-Based Biopolymers as a Direct Alternative to Synthetic Plastics'. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, . [DOI]
2021 Munir M, Jena L, Kett VL, Dunne NJ, McCarthy HO. (2021) 'Spray drying: Inhalable powders for pulmonary gene therapy'. Materials Science and Engineering C, :1-13. [DOI]
2021 Jena, L.N.; Bennie, L.A.; McErlean, E.M.; Pentlavalli, S.; Glass, K.; Burrows, J.F.; Kett, V.L.; Buckley, N.E.; Coulter, J.A.; Dunne, N.J.; McCarthy, H.O. (2021) 'Exploiting the anticancer effects of a nitrogen bisphosphonate nanomedicine for glioblastoma multiforme'. Journal of Nanobiotechnology, 19 . [Link] [DOI]
2021 McGivern, S; Boutouil, H; Al-Kharusi, G; Little, S; Dunne, NJ; Levingstone, TJ (2021) 'Translational Application of 3D Bioprinting for Cartilage Tissue Engineering'. Bioengineering (Basel, Switzerland), 8 (10). [DOI]
2021 Levingstone T, Ali B, Kearney C, Dunne N. (2021) 'Hydroxyapatite sonosensitization of ultrasound‐triggered, thermally responsive hydrogels: An on‐demand delivery system for bone repair applications'. Materials Science and Engineering C, . https://doi.org/10.1002/jbm.b.34820
2021 McGauran, T.; Harris, M.; Dunne, N.; Smyth, B.M.; Cunningham, E. (2021) 'Development and optimisation of extruded bio-based polymers from poultry feathers'. European Polymer Journal, 158 . [Link] [DOI]
2021 O'Brolcháin, F.; Gordijn, B.; Byrne, G.; Dunne, N. (2021) 'Ethical aspects of the biologicalisation of manufacturing'. CIRP Journal of Manufacturing Science and Technology, . [Link] [DOI]
2021 McGauran, T.; Dunne, N.; Smyth, B.M.; Cunningham, E.; Harris, M. (2021) 'Poultry feather disulphide bond breakdown to enable bio-based polymer production'. Polymers from Renewable Resources, . [Link] [DOI]
2021 Mulholland, E.J.; McErlean, E.M.; Dunne, N.; McCarthy, H.O. (2021) 'Design of a novel electrospun PVA platform for gene therapy applications using the CHAT peptide'. International Journal of Pharmaceutics, 598 . [Link] [DOI]
2021 McGauran, T.; Dunne, N.; Smyth, B.M.; Cunningham, E. (2021) 'Feasibility of the use of poultry waste as polymer additives and implications for energy, cost and carbon'. Journal of Cleaner Production, 291 . [Link] [DOI]
2021 Redmond J; McCarthy H; Buchanan P; Levingstone TJ; Dunne NJ; (2021) 'Advances in biofabrication techniques for collagen-based 3D in vitro culture models for breast cancer research'. Materials Science and Engineering C, 122 . [DOI]
2021 McErlean, E.M.; McCrudden, C.M.; McBride, J.W.; Cole, G.; Kett, V.L.; Robson, T.; Dunne, N.J.; McCarthy, H.O. (2021) 'Rational design and characterisation of an amphipathic cell penetrating peptide for non-viral gene delivery'. International Journal of Pharmaceutics, 596 . [Link] [DOI]
2021 McErlean, E.M.; Ziminska, M.; McCrudden, C.M.; McBride, J.W.; Loughran, S.P.; Cole, G.; Mulholland, E.J.; Kett, V.; Buckley, N.E.; Robson, T.; Dunne, N.J.; McCarthy, H.O. (2021) 'Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery'. Journal of Controlled Release, 330 . [Link] [DOI]
2021 Paz, E.; Ballesteros, Y.; Abenojar, J.; Dunne, N.; Del Real, J.C. (2021) 'Advanced g-mps-pmma bone cements: Influence of graphene silanisation on fatigue performance, thermal properties and biocompatibility'. Nanomaterials, 11 . [Link] [DOI]
2021 O'Connor, J.D.; Hill, J.C.; Beverland, D.E.; Dunne, N.J.; Lennon, A.B. (2021) 'Influence of preoperative femoral orientation on radiographic measures of femoral head height in total hip replacement'. Clinical Biomechanics, 81 . [Link] [DOI]
2021 Levingstone T; Ali B; Kearney C; Dunne N; (2021) 'Hydroxyapatite sonosensitization of ultrasound-triggered, thermally responsive hydrogels: An on-demand delivery system for bone repair applications'. Journal of Biomedical Materials Research - Part B Applied Biomaterials, . [DOI]
2020 Levingstone TJ; Herbaj S; Redmond J; McCarthy HO; Dunne NJ; (2020) 'Calcium Phosphate Nanoparticles-Based Systems for RNAi Delivery: Applications in Bone Tissue Regeneration'. Journal of Nanomaterials, 10 (1). [DOI]
2020 Wang W, Wang Z, Fu Y, Dunne N, Liang C, Luo X, Liu K, Li X, Pang X, Lu K. (2020) 'Improved osteogenic differentiation of human amniotic mesenchymal stem cells on gradient nanostructured Ti surface'. Journal of Biomedical Materials Research - Part A, 108 (9):1824-1833. https://doi.org/10.1002/jbm.a.36948
2020 Wang, W; Wang, ZB; Fu, YT; Dunne, N; Liang, C; Luo, X; Liu, KD; Li, XM; Pang, XN; Lu, K (2020) 'Improved osteogenic differentiation of human amniotic mesenchymal stem cells on gradient nanostructured Ti surface'. Journal of Biomedical Materials Research - Part A, . [DOI]
2020 Ní Shé É; Cassidy J; Davies C; De Brún A; Donnelly S; Dorris E; Dunne N; Egan K; Foley M; Galvin M; Harkin M; Killilea M; Kroll T; Lacey V; Lambert V; McLoughlin S; Mitchell D; Murphy E; Mwendwa P; Nicholson E; O'Donnell D; O'Philbin L; (2020) 'Minding the gap: identifying values to enable public and patient involvement at the pre-commencement stage of research projects'. Research Involvement and Engagement, 6 . [DOI]
2020 Yan L.P.; Castaño I.M.; Sridharan R.; Kelly D.; Lemoine M.; Cavanagh B.L.; Dunne N.J.; McCarthy H.O.; O'Brien F.J. (2020) 'Collagen/GAG scaffolds activated by RALA-siMMP-9 complexes with potential for improved diabetic foot ulcer healing'. Materials Science and Engineering C, 114 . [DOI]
2020 O'Doherty, M; Mulholland, EJ; Chambers, P; Pentlavalli, S; Ziminska, M; Chalanqui, MJ; Pauly, HM; Sathy, BN; Donahue, TH; Kelly, DJ; Dunne, N; McCarthy, HO (2020) 'Improving the Intercellular Uptake and Osteogenic Potency of Calcium Phosphate via Nanocomplexation with the RALA Peptide'. Journal of Nanomaterials, 10 . [DOI]
2020 McGauran, T.; Dunne, N.; Smyth, B.M.; Cunningham, E. (2020) 'Incorporation of poultry eggshell and litter ash as high loading polymer fillers in polypropylene'. Composites Part C: Open Access, 3 . [Link] [DOI]
2020 Ziminska M.; Wilson J.J.; McErlean E.; Dunne N.; McCarthy H.O. (2020) 'Synthesis and evaluation of a thermoresponsive degradable chitosan-grafted PNIPAAm hydrogel as a smart gene delivery system'. Materials, 13 (11). [DOI]
2020 Zhou, ZX; Lennon, A; Buchanan, F; McCarthy, HO; Dunne, N (2020) 'Binder jetting additive manufacturing of hydroxyapatite powders: Effects of adhesives on geometrical accuracy and green compressive strength'. Additive Manufacturing, 36 . [DOI]
2019 Cole, G.; Ali, A.A.; McErlean, E.; Mulholland, E.J.; Short, A.; McCrudden, C.M.; McCaffrey, J.; Robson, T.; Kett, V.L.; Coulter, J.A.; Dunne, N.J.; Donnelly, R.F.; McCarthy, H.O. (2019) 'DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen'. Acta Biomaterialia, 96 . [Link] [DOI]
2019 Blair RW, Dunne NJ, Lennon AB, Menary GH. (2019) 'Characterisation and constitutive modelling of biaxially stretched poly (L-lactic acid) sheet for application in coronary stents'. Journal of the Mechanical Behavior of Biomedical Materials, 1 (97):346-354. https://doi.org/10.1016/j.jmbbm.2019.05.039
2019 Liao J, Wu S, Li K, Fan Y, Dunne N, Li X. (2019) 'Peptide‐modified bone repair materials: Factors influencing osteogenic activity'. Journal of Biomedical Materials Research - Part A, 107 (7):1491-1512. https://doi.org/10.1002/jbm.a.36663
2019 Gonzalez-Fernandez T, Rathan S, Hobbs C, Pitacco P, Freeman FE, Cunniffe GM, Dunne NJ, McCarthy HO, Nicolosi V, O'Brien FJ, Kelly DJ. (2019) 'Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues'. Journal of controlled release : official journal of the Controlled Release Society, 10 (301):13-27.
2019 Sathy BN, Daly A, Gonzalez-Fernandez T, Cunniffe G, McCarthy HO, Dunne N, Jeon O, Alsberg E, Donahue TL, Kelly DJ. (2019) 'Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells'. Acta Biomaterialia, 1 (88):314-324.
2019 Rutherford M, O'Connor JD, Gill HS, Hill J, Beverland D, Lennon AB, Dunne NJ. (2019) 'Operative and radiographic acetabular component orientation in total hip replacement: Influence of pelvic orientation and surgical positioning technique'. Medical Engineering and Physics, 64 :7-14.
2019 Wang L, Wu S, Cao G, Fan Y, Dunne N, Li X. (2019) 'Biomechanical studies on biomaterial degradation and co-cultured cells: mechanisms, potential applications, challenges and prospects'. Journal of Materials Chemistry B, 7 (47):7439-7459.
2019 Chalanqui MJ, Pentlavalli S, McCrudden C, Chambers P, Ziminska M, Dunne N, McCarthy HO (2019) 'Graphene Oxide and Graphene Reinforced PMMA Bone Cements: Evaluation of Thermal Properties and Biocompatibility'. Materials Science and Engineering C, 95 :409-421.
2019 Paz E.; Ballesteros Y.; Abenojar J.; del Real J.; Dunne N. (2019) 'Graphene oxide and graphene reinforced PMMA bone cements: Evaluation of thermal properties and biocompatibility'. Materials, 12 (19). [DOI]
2019 Rutherford M, O’Connor JD, Hill JC, Beverland DE, Lennon AB, Dunne NJ. (2019) 'Patient positioning and cup orientation during total hip arthroplasty: assessment of current UK practice'. HIP International, 29 (1):89-95. [DOI]
2019 Mulholland, E.J.; Ali, A.; Robson, T.; Dunne, N.J.; McCarthy, H.O. (2019) 'Delivery of RALA/siFKBPL nanoparticles via electrospun bilayer nanofibres: An innovative angiogenic therapy for wound repair'. Journal of Controlled Release, 316 . [Link] [DOI]
2019 Ziminska, M.; Chalanqui, M.J.; Chambers, P.; Acheson, J.G.; McCarthy, H.O.; Dunne, N.J.; Hamilton, A.R. (2019) 'Nanocomposite-coated porous templates for engineered bone scaffolds: A parametric study of layer-by-layer assembly conditions'. Biomedical Materials (Bristol), 14 . [Link] [DOI]
2019 Wang C, Yu B, Fan Y, Ormsby RW, McCarthy HO, Dunne N, Li X. (2019) 'Incorporation of multi-walled carbon nanotubes to PMMA bone cement improves cytocompatibility and osseointegration'. Materials Science and Engineering C, 103 .
2019 Wang, L.; Wu, S.; Cao, G.; Fan, Y.; Dunne, N.; Li, X. (2019) 'Biomechanical studies on biomaterial degradation and co-cultured cells: mechanisms, potential applications, challenges and prospects'. Journal of Materials Chemistry B, 7 . [Link] [DOI]
2019 Paz E.; Ballesteros Y.; Forriol F.; Dunne N.; del Real J. (2019) 'Graphene and graphene oxide functionalisation with silanes for advanced dispersion and reinforcement of PMMA-based bone cements'. Materials Science and Engineering C, 104 . [DOI]
2019 Levingstone TJ; Herbaj S; Dunne NJ; (2019) 'Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration'. Journal of Nanomaterials, 9 (11). [DOI]
2019 Mulholland EJ, Ali A, Robson T, Dunne NJ, McCarthy HO. (2019) 'Delivery of RALA/siFKBPL nanoparticles via electrospun bilayer nanofibres: An innovative angiogenic therapy for wound repair'. Journal of controlled release : official journal of the Controlled Release Society, 28 (316):53-65.
2019 Rutherford M, O'Connor JD, Gill HS, Hill J, Beverland D, Lennon AB, Dunne NJ. (2019) 'Operative and radiographic acetabular component orientation in total hip replacement: Influence of pelvic orientation and surgical positioning technique'. Medical Engineering and Physics, 64 (1):7-14. [DOI]
2019 Liao J, Wu S, Li K, Fan Y, Dunne N, Li X. (2019) 'Peptide-modified bone repair materials: Factors influencing osteogenic activity'. Journal of Biomedical Materials Research - Part A, . [DOI]
2019 Sathy BN, Daly A, Gonzalez-Fernandez T, Olvera D, Cunniffe G, McCarthy HO, Dunne NJ, Jeon O, Alsberg E, Donahue TH, Kelly DJ. (2019) 'Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells'. Acta Biomaterialia, . [DOI]
2019 Blair RW, Dunne NJ, Lennon AB, Menary GH. (2019) 'Multi-objective optimisation of material properties and strut geometry for poly (L-lactic acid) coronary stents using response surface methodology'. PLoS ONE, 14 (8).
2019 Gonzalez-Fernandez T., Rathan S, Hobbs C, Pitacco P, Freeman FE⁠, Cunniffe GM Dunne NJ⁠, McCarthy HO, Nicolosi V., O'Brien FJ, Kelly DJ. (2019) 'Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues'. Journal of Controlled Release, . https://doi.org/10.1016/j.jconrel.2019.03.006
2018 Zhou Z, Cunningham E, Lennon A, McCarthy HO, Buchanan F, Dunne N. (2018) 'Development of three-dimensional printing polymer-ceramic scaffolds with enhanced compressive properties and tuneable resorption'. Materials Science and Engineering C, 93 (1):975-986. [DOI]
2018 McCrudden CM, McBride JW, McCaffrey J, McErlean EM, Dunne NJ, Kett VL, Coulter JA, Robson T, McCarthy HO. (2018) 'Gene therapy with RALA/iNOS composite nanoparticles significantly enhances survival in a model of metastatic prostate cancer'. Cancer Nanotechnology, 9 (1):1-5. [DOI]
2018 O'Connor JD, Rutherford M, Bennett D, Hill JC, Beverland DE, Dunne NJ, Lennon AB. (2018) 'Long-term hip loading in unilateral total hip replacement patients is no different between limbs or compared to healthy controls at similar walking speeds'. Journal of Biomechanics, 80 :8-15. [DOI]
2018 Blair RW, Dunne NJ, Lennon AB, Menary GH. (2018) 'Processing-property relationships of biaxially stretched poly (L-lactic acid) sheet for application in coronary stents'. Journal of the Mechanical Behavior of Biomedical Materials, 86 :113-121. [DOI]
2018 O’Connor JD, Rutherford M, Hill JC, Beverland DE, Dunne NJ, Lennon AB. (2018) 'Effect of combined flexion and external rotation on measurements of the proximal femur from anteroposterior pelvic radiographs'. Journal of Orthopaedics and Traumatology, 104 (4):449-454. [DOI]
2018 Cole G, Ali AA, McCrudden CM, McBride JW, McCaffrey J, Robson T, Kett VL, Dunne NJ, Donnelly RF, McCarthy HO (2018) 'DNA vaccination for cervical cancer: Strategic optimisation of RALA mediated gene delivery from a biodegradable microneedle system'. European Journal of Pharmaceutics and Biopharmaceutics, 127 :288-297. [DOI]
2018 O’Connor J, Rutherford M, Hill J, Beverland D, Dunne N, Lennon A. (2018) 'Statistical Shape Model Based 2D–3D Reconstruction of the Proximal Femur—Influence of Radiographic Femoral Orientation on Reconstruction Accuracy'. Computer methods in biomechanics and biomedical engineering, :153-160. [DOI]
2018 O’Connor JD, Rutherford M, Hill JC, Beverland DE, Dunne NJ, Lennon AB. (2018) 'Effect of combined flexion and external rotation on measurements of the proximal femur from anteroposterior pelvic radiographs'. Journal of Orthopaedic Surgery and Research, 104 (4):449-454. [DOI]
2018 O'Connor, J.D.; Rutherford, M.; Hill, J.C.; Beverland, D.E.; Dunne, N.J.; Lennon, A.B. (2018) 'Effect of combined flexion and external rotation on measurements of the proximal femur from anteroposterior pelvic radiographs'. Revue de Chirurgie Orthopedique et Traumatologique, 104 . [Link] [DOI]
2018 de Lima GG, Traon F, Moal E, Canillas M, Rodriguez MA, McCarthy HO, Dunne N, Devine DM, Nugent MJD. (2018) 'Composite cryogels for dual drug delivery and enhanced mechanical properties'. Polymer Composites, . [DOI]
2018 Zhang K, Fan Y, Dunne N, Li X. (2018) 'Effect of microporosity on scaffolds for bone tissue engineering'. Regenerative Medicine, . [DOI]
2017 O’Neill R, McCarthy HO, Montufar E, Ginebra MP, Wilson DI, Dunne N. (2017) 'Critical Review: Injectability of calcium phosphate pastes and cements'. Acta Biomaterialia, 50 (3):1-19. [DOI]
2017 Paz E, Forriol F, del Real JC, Dunne NJ. (2017) 'Graphene oxide versus graphene for optimisation of PMMA bone cement for orthopaedic applications'. Materials Science and Engineering C, 77 :1003-1011. [DOI]
2017 Gonzalez-Fernandez T, Sathy BN, Hobbs C, Cunniffe GM, McCarthy HO, Dunne NJ, Nicolosi, O’Brien FJ, Kelly DJ. (2017) 'Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector'. Acta Biomaterialia, 55 (6):226-238. [DOI]
2017 Pauly HM, Sathy BN, Olvera D, McCarthy HO, Kelly DJ, Popat KC, Dunne NJ, Haut Donahue TL. (2017) 'Hierarchically structured electrospun scaffolds with chemically conjugated growth factor for ligament tissue engineering'. Tissue Engineering, 23 (8):823-836. [DOI]
2017 McCrudden CM, McBride JW, McCaffrey J, Ali AA, Dunne NJ, Kett VL, Coulter JA, Robson T, McCarthy HO. (2017) 'Systemic RALA/iNOS nanoparticles: A potent gene therapy for metastatic breast cancer coupled as a biomarker of treatment'. Molecular Therapy - Nucleic Acids, 6 (3):249-258. [DOI]
2017 Mulholland EJ, Dunne N, McCarthy HO (2017) 'MicroRNA as therapeutic targets for chronic wound healing'. Molecular Therapy - Nucleic Acids, 8 (9):46-55. [DOI]
2017 Sathy BN, Olvera D, Gonzalez-Fernandez T, Cunniffe GM Pentlavalli S, Chambers P, Jeon O, Alsberg E, McCarthy HO, Dunne NJ, Haut Donahue TL, Kelly DJ. (2017) 'RALA complexed α-TCP nanoparticle delivery to mesenchymal stem cells induces bone formation in tissue engineered constructs in vitro and in vivo'. Journal of Materials Chemistry B, 5 (9):1753-1764. [DOI]
2017 Clarke SA, Martin J, Nelson J, Hornez JC, Bohner M, Dunne N, Buchanan F. (2017) 'Surrogate outcome measures of in vitro osteoclast resorption of beta-tricalcium phosphate'. Advanced healthcare materials, 6 (1). [DOI]
2017 Ali AA, McCrudden CM, McCaffrey , McBride JW, Cole G, Dunne NJ, Robson T, Kissenpfennig A, Donnelly RF, McCarthy HO. (2017) 'DNA vaccination for cervical cancer: a novel technology platform of RALA mediated gene delivery via polymeric microneedles'. Nanomedicine: Nanotechnology, Biology, and Medicine, 13 (3):921-932. [DOI]
2017 Zhou Z, Cunningham E, Lennon E, McCarthy HO, Buchanan F, Clarke SA, Dunne N. (2017) 'Effects of poly (ε-caprolactone) coating on the properties of three-dimensional printed porous structures'. Journal of the Mechanical Behavior of Biomedical Materials, 70 (6):68-83. [DOI]
2017 Pentlavalli S, Chambers P, Sathy BN, O’Doherty M, Chalanqui M, Kelly DJ, Haut-Donahue T, McCarthy HO, Dunne NJ (2017) 'Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) injectable thermoresponsive hydrogel with the potential for localized and sustained delivery of stem cells and bioactive molecules'. Macromolecular Bioscience, 17 (11). [DOI]
2017 Chalanqui, MJ and Pentlavalli, S and McCrudden, C and Chambers, P and Ziminska, M and Dunne, N and McCarthy, HO (2017) 'Influence of alginate backbone on efficacy of thermo-responsive alginate-gP (NIPAAm) hydrogel as a vehicle for sustained and controlled gene delivery'. Materials Science and Engineering C, . [DOI]
2016 Paz E, Abenojar J, Ballesteros Y, Forriol F, Dunne NJ, Del Real JC. (2016) 'Mechanical and thermal behaviour of an acrylic bone cement modified with a triblock copolymer'. Journal of Materials Science: Materials in Medicine, 27 (4):71-81. [DOI]
2016 McBride JW, Massey AS, McCaffrey J, M McCrudden C, Coulter JA, Dunne NJ, Robson T, McCarthy HO. (2016) 'Development of TMTP-1 targeted designer biopolymers for gene delivery to prostate cancer'. International Journal of Pharmaceutics, (1-2):144-153. [DOI]
2016 Ziminska M, Dunne N, Hamilton A. (2016) 'Porous materials with tunable structure and mechanical properties via templated layer-by-layer assembly'. ACS applied materials & interfaces, 8 (34):21968-21973. [DOI]
2016 Pauly HM, Kelly DJ, Popat KC, Trujillo NA, Dunne NJ, McCarthy HO, Haut Donahue TL. (2016) 'Mechanical properties and cellular response of novel electrospun nanofibers for ligament tissue engineering: Effects of orientation and geometry'. Journal of the Mechanical Behavior of Biomedical Materials, 61 (8):258-270. [DOI]
2016 Chalanqui MJ, O’Doherty M, Dunne NJ, McCarthy HO. (2016) 'MiRNA 34a: A therapeutic target for castration-resistant prostate cancer'. Expert Opinion on Therapeutic Targets, 20 (9):1075-1085. [DOI]
2016 Clarke SA, Choi SY, McKechnie M, Burke G, Dunne N, Walker G, Cunningham E, Buchanan F. (2016) 'Osteogenic cell response to 3-D hydroxyapatite scaffolds developed via replication of natural marine sponges'. Journal of Materials Science: Materials in Medicine, 27 (2):22-33. [DOI]
2016 O’Neill R, Montufar E, Ginebra M-P, D. Wilson I, Cunningham E, McCarthy HO, Lennon A, Dunne N. (2016) 'Extent and mechanism of phase separation during the extrusion of calcium phosphate pastes'. Journal of Materials Science: Materials in Medicine, 27 (2):29-42. [DOI]
2016 Palmer I, Nelson J, Schatton W, Dunne NJ, Buchanan F, Clarke SA. (2016) 'Biocompatibility of calcium phosphate bone cement with optimised mechanical properties: an in vivo study'. Journal of Materials Science: Materials in Medicine, 27 (12):191-201. [DOI]
2016 Palmer I, Nelson J, Schatton W, Dunne N, Buchanan F, Clarke SA. (2016) 'Biocompatibility of calcium phosphate bone cement with optimised mechanical properties'. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 104 (2):308-315. [DOI]
2015 Hagan C, Orr JF, Mitchell CA, Dunne NJ. (2015) 'Critical evaluation of pulse-echo ultrasonic test method for the determination of setting and mechanical properties of acrylic bone cement: Influence of mixing technique'. Ultrasonics, :279-286. [DOI]
2015 Goel S, Beake B, Chan CW, Faisal NH, Dunne N. (2015) 'Twinning anisotropy of tantalum during nanoindentation'. MATERIALS SCIENCE AND ENGINEERING A, 627 (11):249-261. [DOI]
2014 Zhou Z, Buchanan F, Mitchell C, Dunne NJ. (2014) 'Printability of calcium phosphate:calcium sulphate powders for the application of tissue engineered bone scaffolds using the 3D printing technique'. Materials Science and Engineering C, 38 :1-19. [DOI]
2014 McCarthy HO, McCaffrey J, McCrudden CM, Zholobenko A, Ali A, McBride JW, Massey AS, Pentlavalli S, Chen K-H, Cole G, Loughran SP, Dunne NJ, Donnelly RF, Kett VL, Robson T. (2014) 'Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery'. Journal of Controlled Release, 189 (10):141-149. [DOI]
2014 Clements J, Walker G, Pentlavalli S, Dunne NJ. (2014) 'Optimisation of a two-liquid component pre-filled acrylic bone cement system: A design of experiments approach to optimise cement final properties'. JOURNAL OF MATERIALS SCIENCE : MATERIALS IN MEDICINE, 25 (10):2287-2296. [DOI]
2014 Ormsby RW, McNally T, Mitchell C, Musumeci A, Schiller T, Halley P, Gahan L, Martin D, Smith SV, Dunne NJ. (2014) 'Chemical modification of multiwalled carbon nanotube with a bifunctional caged ligand for radioactive labelling'. Acta Materialia, 64 (2):54-61. [DOI]
2014 Tarsuslugil S, O’Hara R, Dunne NJ, F Buchanan, J Orr, D Barton, R Wilcox. (2014) 'A combined experimental and finite element modelling approach to predict, evaluate and compaschre the use of PMMA and calcium phosphate cements for augmentation of traumatically fractured porcine vertebrae using vertebroplasty'. Annals of Biomedical Engineering, 42 (4):751-762. [DOI]
2014 Ormsby RW, Modreanu M, Mitchell CA, Dunne NJ. (2014) 'Carboxyl functionalised MWCNT/Polymethyl methacrylate bone cement for orthopaedic applications'. 29 (2):209-221. [DOI]
2013 Tarsuslugil S, O’Hara R, Dunne NJ, F Buchanan, J Orr, D Barton, R Wilcox. (2013) 'Development of calcium phosphate cements for the augmentation of traumatically fractured porcine specimens using vertebroplasty'. Journal of Biomechanics, 46 (4):711-715. [DOI]
2012 Ormsby R, McNally T, O’Hare P, Burke G, Mitchell C, Dunne NJ. (2012) 'Fatigue and biocompatibility properties of a poly(methyl methacrylate) bone cement with multi-walled carbon nanotubes'. Acta Biomaterialia, 8 (3):1201-1212. [DOI]
2012 Newe C, Cunningham E, Buchanan F, Walker G, Prendergast P, Lennon A, Dunne N. (2012) 'Static and dynamic degradation of sintered calcium phosphate ceramics'. Key Engineering Materials, 493-494 :861-865. [DOI]
2012 O’Hara R, Orr J, Buchanan F, Wilcox R, Barton D, Dunne NJ. (2012) 'Development of a bovine collagen-apatitic calcium phosphate cement for potential fracture treatment through vertebroplasty'. Acta Biomaterialia, 8 (11):4043-4052. [DOI]
2012 Fee K, Walker G, Dunne NJ, Buchanan FJ. (2012) 'Hydrothermal synthesis of coccolith rich chalk to hydroxyapatite'. International Journal of Nano and Biomaterials, 4 (2):81-95. [DOI]
2012 Dunne NJ, O’Hara R, Buchanan F, Orr J. (2012) 'Effect of liquid/powder ratio on the setting, handling and mechanical properties of collagen–apatitic cements'. Key Engineering Materials, 493-494 :415-421. [DOI]
2012 Palmer I. Clarke SA, Nelson J, Schatton W, Dunne NJ, Buchanan Fj. (2012) 'Identification of a suitable sterilisation method for collagen derived from a marine Demosponge'. International Journal of Nano and Biomaterials, 4 (2):148-163. [DOI]
2011 Cunningham E, Dunne NJ, Clarke SA, Choi SY, Walker G, Wilcox R, Unger RE, Buchanan F, Kirkpatrick CJ. (2011) 'Comparative characterization of 3-D hydroxyapatite scaffolds developed via replication of synthetic polymer foams and natural marine sponges'. Journal of Tissue Engineering, 1 :1-9. [DOI]
2011 Ormsby R, McNally T, Mitchell C, Halley P, Martin D, Nicholson T, Dunne N. (2011) 'Effect of MWCNT addition on the thermal and rheological properties of polymethyl methacrylate bone cement'. Carbon, 49 (11):2893-2904. [DOI]
2010 McEleney P, Walker G, Orr JF. Dunne NJ. (2010) 'Investigations on drop penetration and wetting characteristics of powder-liquid systems in relation to the mixing of acrylic bone cement'. International Journal of Nano and Biomaterials, 3 (1):20-35. [DOI]
2010 Ormsby R. McNally T, Mitchell C, Dunne NJ. (2010) 'Incorporation of multiwalled carbon nanotubes to acrylic based bone cements: Effects on mechanical and thermal properties'. Journal of the Mechanical Behavior of Biomedical Materials, 3 (2):136-145. [DOI]
2010 Cunningham E, Dunne NJ, Walker G, Maggs C, Wilcox R, Buchanan FJ. (2010) 'Hydroxyapatite bone substitutes developed via replication of natural marine sponges'. Journal of Materials Science: Materials in Medicine, 21 (8):2255-2261. [DOI]
2010 Ormsby R, McNally T, Mitchell CA, Dunne NJ. (2010) 'Influence of multiwall carbon nanotube functionality and loading on mechanical properties of PMMA/MWCNT bone cements'. Journal of Materials Science: Materials in Medicine, 21 (8):2287-2292. [DOI]
2010 O’Hara RM, Dunne NJ, Orr JF, Buchanan FJ, Wilcox RK, Barton DC. (2010) 'Optimisation of the mechanical and handling properties of an injectable calcium phosphate cement'. Journal of Materials Science: Materials in Medicine, 21 (8):2299-2305. [DOI]
2010 Dunne NJ, Jack, V, O'Hara R, Farrar D, Buchanan FJ. (2010) 'Performance of calcium deficient hydroxyapatite–polyglycolic acid composites: an in vitro study'. Journal of Materials Science: Materials in Medicine, 21 (8):2263-2270. [DOI]
2004 Dunne, NJ; Orr, JF (2004) 'Curing characteristics of acrylic bone cement'. Journal of materials science. Materials in medicine, 13 (1). [DOI]
2002 Dunne, NJ; Orr, JF; Mushipe, MT; Eveleigh, RJ (2002) 'The relationship between porosity and fatigue characteristics of bone cements'. Biomaterials, 24 (2). [DOI]
2001 Dunne, N.J.; Orr, J.F. (2001) 'Thermal characteristics of curing acrylic bone cement'. ITBM-RBM, 22 . [Link] [DOI]
2001 Dunne, NJ; Orr, JF (2001) 'Influence of mixing techniques on the physical properties of acrylic bone cement'. Biomaterials, 22 (13). [DOI]
2000 Dunnc, N.J. (2000) 'Development of a computer model to predict pressure generation around hip replacement stems'. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 214 . [Link] [DOI]
2000 Dunne, N.; Orr, J. (2000) 'Bone cement mixing. Theatre staff's views and opinions'. British journal of perioperative nursing : the journal of the National Association of Theatre Nurses, 10 . [Link] [DOI]

Conference Publication

Year Publication
2022 Spanias, A.; Narayanaswamy, V.; Forzani, E.; Raupp, G.; Kellam, N.; O'Donnell, M.; Barnard, W.; Larson, J.; O'Connor, N.; Dunne, N.; Daniels, S.; Little, S. (2022) 13th International Conference on Information, Intelligence, Systems and Applications, IISA 2022 The ASU-DCU International Research and Workforce Development Program on Sensors and Machine Learning [Link] [DOI]
2004 Hingston J.; McGuinness G.; Looney L.; Dunne N.; Orr J. (2004) Transactions - 7th World Biomaterials Congress Computational analysis of bone cement thermal shrinkage about the stem/cement interface
2004 Orr J.; Dunne N.; Hingston J.; McGuinness G.; Mitchell J.; Cabrera N. (2004) Transactions - 7th World Biomaterials Congress The effect of shrinkage on stresses in a mantle of curing acrylic bone cement

Other Publication

Year Publication
2022 Sun, Y.; Juncos Bombin, A.D.; Boyd, P.; Dunne, N.; McCarthy, H.O. (2022) Application of 3D printing & 3D bioprinting for promoting cutaneous wound regeneration. [Link] [DOI]
2021 Munir, M.; Jena, L.; Kett, V.L.; Dunne, N.J.; McCarthy, H.O. (2021) Spray drying: Inhalable powders for pulmonary gene therapy. [Link] [DOI]
Certain data included herein are derived from the © Web of Science (2023) of Clarivate. All rights reserved.

Professional Associations

Association Function From / To
Institute of Materials, Minerals and Mining Fellow 01/01/2009 -
Higher Education Academy Member 01/01/2004 -
Institute of Materials, Minerals and Mining Chartered Engineer 01/01/2000 -

Honors and Awards

Date Title Awarding Body
01/09/2017 Journal of Materials Science: Materials in Medicine Award Best Paper Award Journal of Materials Science: Materials in Medicine Award Best Paper Award (Springer)
01/09/2010 Royal Academy of Engineering/Leverhulme Trust Senior Research Fellow Award Royal Academy of Engineering & Leverhulme Trust
01/04/2009 Northern Ireland Biomedical Engineering Society Best Paper Award Northern Ireland Biomedical Engineering Society
01/02/2009 Orthopaedic Research Society/British Orthopaedic Research Society Travel Fellowship Orthopaedic Research Society & British Orthopaedic Research Society
01/07/2008 UK Society of Biomaterials Best Paper Award UK Society of Biomaterials
01/04/2008 DePuy International Award Best Paper Award Northern Ireland Biomedical Engineering Society
01/04/2008 Institute of Materials, Minerals and Mining Best Paper Award Institute of Materials, Minerals and Mining
01/09/2007 Journal of Materials Science: Materials in Medicine Award Best Paper Award European Society Meeting
01/01/2006 Reserve Royal Academy of Medicine in Ireland Bronze medal Royal Academy of Medicine in Ireland
01/06/2002 IMechE: Medical Engineering Division Duncan Dowson Prize Institution of Mechanical Engineers

Committees

Committee Function From / To
8th World Biomechanics Congress 01/06/2015 - 30/07/2018
11th World Biomaterials Congress 01/05/2012 - 31/05/2020
UK Society of Biomaterials 01/07/2011 - 30/06/2015
European Society of Biomaterials 01/09/2010 - 01/09/2014
Northern Ireland Biomedical Engineering Society 01/01/2008 - 31/12/2015
Journal of Materials Science – Materials in Medicine 01/01/2014 -
ISRN Biomaterials 01/01/2012 -
BioMed Research International 01/01/2012 -
International Journal of Nano and Biomaterials 01/01/2010 -
The Open Mechanical Engineering Journal 01/01/2007 -

Employment

Employer Position From / To
Trinity College Dubliin Adjunct Professor of Biomaterials Engineering 01/05/2016 -
Queen's University of Belfast Visiting Research Professor of Biomaterials Engineering 01/04/2016 -
Dublin City University Director of Centre for Medical Engineering Research 01/01/2016 -
Dublin City University Full Professor (Chair) of Mechanical & Manufacturing Engineering 01/01/2016 -
Queen's University of Belfast Full Professor of Biomaterials Engineering 01/06/2015 - 31/12/2015
Queen's University of Belfast Director of Advanced Materials and Processes Research Cluster 01/01/2013 - 13/11/2017
Queen's University of Belfast Director of Polymer Processing Research Centre 01/12/2013 - 31/12/2015
Queen's University of Belfast Reader 01/10/2010 - 30/05/2015
Queen's University of Belfast Senior Lecturer of Mechanical & Manufacturing Engineering 01/10/2008 - 30/09/2010
Queen's University Belfast Lecturer of Mechanical & Manufacturing Engineering 01/02/2003 - 03/09/2008
Dublin City University Lecturer of Mechanical & Manufacturing Engineering 01/02/2000 - 31/01/2003
Cork Institute of Technology Lecturer of Mechanical & Manufacturing Engineering 01/09/1998 - 31/01/2000
DePuy International, Leeds (UK) Biomaterials Engineer 01/09/1996 - 31/08/1998

Education

Start date Institution Qualification Subject
Dublin City University / Institute of Leadership & Management University Leadership and Management Programme
Queen's University of Belfast Ph.D.
Queen's University of Belfast Postgraduate Certificate in Higher Education Teaching
Athlone Regional Technical College B.Sc. (Hons.)

Research Interests

Professor Dunne leads a multidisciplinary group focussed on the development of biomaterials and medical devices that simulate an efficacious drug delivery or therapeutic response. This research programme spans understanding fundamental mechanisms at the host/material interface as well as translational research to target non-union bone defects, bone metastases and chronic wounds. 

Research Projects

Title Role Description Start date End date
Controlled immune response to enhance bone healing DCU Co-I 01/06/2023 31/05/2027
A nanoparticle-loaded hydrogel for Epidermolysis Bullosa DCU PI 01/09/2022 31/08/2024
Development of machine learning tools to predict pathological sequalae of traumatic brain injury DCU PI 01/01/2023 31/12/2027
RALA nanocomplexes as a platform to mediate oral delivery of peptides using insulin as a prototype Co-Investigator 01/09/2022 31/08/2024
Sensor Information Processing and Machine Learning for Wearable Devices Co-Investigator 01/06/2022 31/05/2026
Design of Genetically Engineered Tensile Load-Bearing Soft Tissues Inspired by Embryonic Tendon Development Co-Investigator 01/08/2022 31/07/2025
An instant repair biomimetic treatment for brittle bone fracture for patients with osteoporosis Principal Investigator 01/06/2022 31/05/2025
Learning to search with structure (LESS), a unifying algorithmic framework for gray box optimization of biomanufacturing systems DCU PI 01/09/2021 31/08/2025
Biomechanical evaluation of reality-based navigation in total hip replacement DCU Co-I 01/01/2021 31/12/2024
Influence of Surface Coating on the Biofunctionalisation of Additively Manufactured Metallic Orthopaedic Implants DCU PI 01/10/2020 30/09/2022
Application of artificial intelligence in the development of bioprinted scaffolds for cartilage tissue engineering DCU Co-I 01/10/2020 30/09/2024
Osteoinduction Augmented Magnesium Medical Implants for Skeletal Repair DCU PI 01/10/2020 30/09/2024
Combing artificial intelligence and lab-on-a-chip technologies for biomaterials optimisation DCU Co-I 01/10/2020 30/09/2024
Collagen bioink optimisation for 3D bioprinting using artificial intelligence methods Co-Investigator 01/10/2019 30/09/2023
3D Printed Medical-Grade Metal-based Microneedles as a Modular Platform for Minimally Invasive Therapeutic Delivery DCU PI 01/10/2019 31/12/2023
Safety and efficacy of a Class III medical device loaded with nanoparticles for non-union fracture repair DCU PI 01/09/2019 30/08/2021
Active aGeIng and Osteoporosis: The next challenge for smarT nanobiOmaterials and 3D technologies (GIOTTO) PI 01/01/2019 31/03/2022
Additive manufacturing of advanced hybrid medical devices Co-I 01/01/2019 31/12/2019
Non-viral delivery of genetic cargo on biomaterial scaffolds for bone regeneration Co-I 01/01/2019 31/12/2021
Development of a Nanomedicine in an Electrospun Patch for Wound Healing Co-I 01/10/2018 30/09/2022
Development of a Class III medical device loaded with nanoparticles for enhanced in situ bone regeneration Co-I 01/03/2018 28/02/2019
Development of an ultrasound triggered, thermally responsive hydrogel as an on-demand delivery system for bone repair Co-I 01/03/2018 28/02/2019
Engineering collagen based scaffolds for advanced ex vivo culture of breast tumours in a metastatic bone microenvironment PI 02/10/2017 30/09/2019
Identify new life like materials used in medical simulation training that are cost effective, durable and manufacturable using existing technologies Co-I 01/11/2016
A new pro-angiogenic nanomedicine for chronic wound healing Co-I 02/10/2016 30/09/2016
FKBPL Gene Therapy: An alternative anti-angiogenic for macular degeneration Co-I 01/09/2016
Advanced thermo-sensitive medical devices for targeted regeneration of endochondral bone at the bone-tissue interface PI 01/09/2015 31/08/2016
Building the QUB anti-microbial research (AMR) network Co-I 01/09/2015 30/09/2017
Bi-axial Stretching of PLLA-WS2 nanocomposites for thinner and stronger biomedical bi-stretch-4-biomed scaffolds Co-I 01/09/2015 31/08/2019
Development of novel biopolymer functional additives from poultry waste streams Co-I 01/09/2015 30/04/2019
Development of multi-functional thermo-sensitive hydrogels for the treatment of bone metastases Co-I 01/09/2014
Femoral and acetabular implant placement optimisation during total hip arthroplasty PI 01/09/2014 28/02/2018
Growing synthetic load-bearing materials: Nanoscale fabrication of bioinspired materials for macro-scaler structural and biomedical application Co-I 01/08/2014 31/07/2018
Enhanced process monitoring and control technology to accelerate development of bioresorbable polymeric medical devices Co-I 01/12/2013 30/11/2016
Development of a novel bioinspired fibre reinforced hydrogel that recapitulates the developmental processes to regenerate the bone-ligament interface PI 01/12/2013 30/11/2016
Bio TP Seal-Reduction Plastics PI 01/12/2013 30/11/2016
Development of thermo-sensitive growth factor delivering hydrogels incorporating CaP releasing nanoparticles for the targeted promotion of endochondral bone formation to facilitate strategic regeneration of bone-tissue interface PI 01/10/2013 30/09/2015
Development of a fully integrated intelligent bone cement mixing and delivery system PI 01/10/2013 30/09/2015
Measurement and control of pelvic orientation during total hip arthroplasty PI 01/09/2013
Novel polymer systems for closure of laparoscopic port defects PI 01/07/2013 30/06/2015
A minimally invasive solution for the treatment of spinal fractures PI 01/09/2012 31/08/2014

Contract Researchers

Researcher Name Project Funding Body
Srishti Agrawal (Current Postdoctoral Researcher) An instant repair biomimetic treatment for brittle bone fracture for patients with osteoporosis
Ahmed Elkashif (Current Postdoctoral Researcher) Design of Genetically Engineered Tensile Load-Bearing Soft Tissues Inspired by Embryonic Tendon Development
Satish Jaiswal (Current Postdoctoral Researcher) An instant repair biomimetic treatment for brittle bone fracture for patients with osteoporosis
Subrata Mondal (Current Postdoctoral Researcher) Multiscale modelling and design of nanomaterial-based medical devices for osteoporotic fracture repair
Seyedeh Zohreh Mousavi Nejad (Current Postdoctoral Researcher) A nanoparticle-loaded hydrogel for Epidermolysis Bullosa
John Redmond (Current Postdoctoral Researcher) An instant repair biomimetic treatment for brittle bone fracture for patients with osteoporosis
Tehseen Riaz (Current Postdoctoral Researcher) Design of Genetically Engineered Tensile Load-Bearing Soft Tissues Inspired by Embryonic Tendon Development
Ghayadah Al-Kharusi (Current PhD Student) Collagen bioink optimisation for 3D bioprinting using artificial intelligence methods
Peter Bennett (Current PhD Student) Subcutaneous implantable cardiac defibrillator
Halima Boutouil (Current PhD Student) Application of artificial intelligence in the development of bioprinted scaffolds for cartilage tissue engineering
Brian Collins (Current PhD Student) Combing artificial intelligence and lab-on-a-chip technologies for biomaterials optimisation
Oscar Denton (Current PhD Student) Biomechanical evaluation of reality-based navigation in total hip replacement
Cesar Faurat-Narkisian (Current PhD Student) Growing synthetic load-bearing biomaterials
Tina Sadat Hashemi (Current PhD Student) Osteoinduction augmented magnesium medical implants for skeletal repair
Zahra Kharat (Current PhD Student) Controlled immune response to enhance bone healing
Beth Macaulay (Current MSc Student) Influence of surface coating on the biofunctionalisation of additively manufactured metallic orthopaedic implants
Ali Rostamalilou (Current PhD Student) Development of machine learning tools to predict pathological sequalae of traumatic brain injury
Muhammad Saeed (Current PhD Student) Application of machine learning in nanoparticle synthesis for biomaterial-drug combination applications
Chayanika Saha (Current PhD Student) Development of a controlled release DNA vaccine for ovarian cancer
Mohammadali Sahebalzamani (Current PhD Student) Multifunctional bone scaffold materials for segmental bone defect repair
Nikoletta Sargioti (Current PhD Student) 3D printed medical grade metal-based microneedles as a modular platform for minimally invasive therapeutic delivery
Ying Sun (Current PhD Student) 3D printed drug-biomaterial combinations for bone tissue engineering
Antzela Tzagiollari (Current PhD Student) Development of a Bioresorbable and Biomimetic Bone Adhesive for the regeneration of bone defects
Ahlam Abdunnabi Ali (Completed) A new pro-angiogenic nanomedicine for chronic wound healing
Philip Chambers (Completed) Development of the RALA delivery platform
Grace Cole (Completed) FKBPL Gene Therapy: An alternative anti-angiogenic for macular degeneration
Eoin Cunningham (Completed) Collagen fibre-calcium phosphate cement
Lynn Jena (Completed) Safety and efficacy of a Class III medical device loaded with nanoparticles for non-union fracture repair
Rebecca Lane (Completed) Development of a fully integrated intelligent bone cement mixing and delivery system
Ashley Massey (Completed) Collagen fibre-calcium phosphate cement
John McBride (Completed) Additive manufacturing of advanced hybrid medical devices
Emma McErlean (Completed) Development of a mRNA vaccine in a Microneedle Patch for Castrate Resistant Prostate Cancer
Michelle O’Doherty (Completed) Advanced manufacture of thermo-sensitive medical devices for targeted regeneration of endochondral bone at the bone-tissue interface
Ross Ormsby (Completed) Minimally invasive solution for spinal fractures
Iwan Palmer (Completed) Collagen fibre-calcium phosphate composite cement
Sreekanth Pentlavalli (Completed) Novel bioinspired fibre reinforced hydrogel to regenerate the bone-ligament interface
Monika Ziminska (Completed) Development of a Class III medical device loaded with nanoparticles for enhanced in situ bone regeneration
Monika Ziminska (Current) Non-viral delivery of genetic cargo on biomaterial scaffolds for bone regeneration
Jonathan Acheson (Graduated) Layer by layer assembly as a bottom-up nanofabrication technique for the manufacture of engineered bone tissue scaffolds
Ross Blair (Graduated) Combined experimental and computational framework to optimise processing and design of PLLA bioresorbable vascular scaffolds
Marine Chalanqui (Graduated) Development of multi-functional thermo-sensitive hydrogels for the treatment of bone metastases
Philip Chambers (Graduated) Development of a novel bioinspired fibre reinforced hydrogel
Yixuan Chen (Graduated MSc Student) Delivery systems for the genetic engineering of T-Cells
James Clements (Graduated) Optimisation of PMMA bone cement mixing and delivery
Kathryn Fee (Graduated) Development of marine-derived biomaterials for bone tissue engineering
Badriah Fma Al (Graduated) Development of an ultrasound triggered, thermally responsive hydrogel as an on-demand delivery system for bone repair
Sara López de Armentia Hernández (Graduated PhD Student) Development of nanomaterial based scaffolds for bone tissue regeneration
Adrian Juncos Bombin (Graduated PhD Student) Development of a Nanomedicine in an Electrospun Patch for Wound Healing
Chiara MacBhrien (Graduated) Development of computational models of multi-walled carbon nanotube reinforced bone cements to enable long-term simulation of fatigue failure of cemented orthopaedic implants
Thomas McGauran (Graduated) Development of Biopolymers additives from poultry waste
Joanne Millar (Graduated) Cell mediated bioresorption of calcium phosphate bone substitutes
Eoghan Mulholland (Graduated) Nucleic acid based nanomedicine for chronic wound treatment
Miftakuk Munir (Graduated PhD Student) Development of an inhalable nanomedicine for lung cancer therapy
Caroline Newe (Graduated) Development of tissue engineered scaffolds
John O’Connor (Graduated) Femoral and acetabular implant placement optimisation during total hip arthroplasty
Rory O’Neill (Graduated) Computational and experimental optimisation of calcium phosphate for bone augmentation through vertebroplasty
Iwan Palmer (Graduated) In-vitro and In-vivo testing of biomaterials for spinal repair
John Redmond (Completed) Engineering collagen based scaffolds for advanced ex vivo culture of breast tumours in a metastatic bone microenvironment
Paul Ricketts (Graduated) Direct adsorption of antibiotics onto hydroxyapatite surfaces
Megan Rutherford (Graduated PhD Student) Measurement and control of pelvic orientation during total hip arthroplasty
Zuoxin Zhou (Graduated) Design and optimisation of tissue engineering scaffolds
Monika Ziminska (Graduated) Nanocomposite-coated foams for mechanical reinforcement of bone tissue scaffolds and targeted drug delivery

External Collaborators

Type Name Company Role
External Fergal O'Brien Royal College of Surgeons in Ireland Academic
External Professor Helen McCarthy Queen's University Belfast Academic
External Giulia Pedrielli Arizona State University Academic
External Chiara Vitale-Brovarone Politecnico di Torino Academic
External Seth Donahue University of Massachusetts, Amherst Academic
External Spencer Szczesny Penn State University Academic
External David Brayden University College Dublin Academic
External Paula Murphy Trinity College Dublin Academic
External Andreas Spanias Arizona State University Academic
External Gerard Insley PBC Biomed Ltd. Industry

Teaching Interests

The modules that I teach at Undergraduate and Postgraduate level include:

  1. Strength of Materials I (MM211)
  2. Product Development & Regulatory Compliance (MM371)
  3. Biomaterials (MM413)
  4. Advanced Engineering Materials & Manufacturing Processes (MM409)
  5. Research Practice & Methodologies (MM533)

Modules Coordinated

Term Title Subject
2022 Research Practice & Methodology MM533
2022 Strength of Materials I MM211