Back to Search

Andrew Kellett

Prof

Profile Photo
Andrew Kellett is Professor of Inorganic and Medicinal Chemistry in the School of Chemical Sciences at Dublin City University, Ireland. His group are based at the Nano Research Facility (NRF) and the National Institute for Cellular Biotechnology (NICB) and focus on artificial gene editing, metallodrug discovery, and therapeutic nucleic acids. He is a back-to-back coordinator of the Horizon 2020 Marie Skłodowska-Curie Innovative Training Network (ITN) ClickGene and NATURE-ETN. His lab is supported by Science Foundation Ireland (SFI), the Irish Research Council (IRC) and the SFI funded Synthesis and Solid-State Pharmaceutical Centre (SSPC) and CÚRAM. He is a graduate of Maynooth University (B.Sc.) and Technological University Dublin (PhD) and was then appointed as A.F. Graves Postdoctoral Fellow at the Focas Research Institute until 2011 and thereafter joined the School of Chemical Sciences at Dublin City University. In 2022 he was named the SSPC's 'Investigator of the Year' and he also received a prestigious Irish Research Council (IRC) Laureate Consolidator Award.   

Group website: http://www.andrewkellettgroup.com

Book Chapter

Year Publication
2022 Anna Banasiak; Nicolò Zuin Fantoni; Andrew Kellett; John Colleran (2022) 'Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors' In: Biomimetic Radical Chemistry and Applications 2021. Basel : MDPI. [Link] [DOI]
2020 Molphy Z., McKee V., Kellett A. (2020) 'Biomimetic Radical Chemistry and Applications' In: Biomimetic Radical Chemistry and Applications. Basel, Switzerland : MDPI.
2019 Kellett, A.; Molphy, Z.; McKee, V.; Slator, C. (2019) 'Recent Advances in Anticancer Copper Compounds' In: Rsc Metallobiology. [Link] [DOI]
2019 Kellett, A; Molphy, Z; Mckee, V; Slator, C (2019) 'Recent Advances in Anticancer Copper Compounds' In: METAL-BASED ANTICANCER AGENTS. CAMBRIDGE : ROYAL SOC CHEMISTRY.
2015 Molphy Z., Slator C., Chatgilialoglu C., Kellett A. (2015) 'DNA oxidation profiles of copper phenanthrene chemical nucleases' In: Monari A., Dumont E. and Chatgilialoglu C(Eds.). Radiation-induced and oxidative DNA damages. Lausanne : Frontiers Media. [DOI]

Peer Reviewed Journal

Year Publication
2023 Bethany Searle; Markus Müller; Thomas Carell; Andrew Kellett (2023) 'Third Generation Sequencing of Epigenetic DNA'. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, . [Link] [DOI]
2023 Seán O’Halloran; Abhay Pandit; Andreas Heise; Andrew Kellett (2023) 'Two-Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies'. Advanced Science (Weinheim, Baden-Wurttemberg, Germany), 10 . [Link] [DOI]
2022 de Souza, ÍP; de Melo, ACC; Rodrigues, BL; Bortoluzzi, A; Poole, S; Molphy, Z; McKee, V; Kellett, A; Fazzi, RB; da Costa Ferreira, AM; Pereira-Maia, EC (2022) 'Antitumor copper(II) complexes with hydroxyanthraquinones and N,N-heterocyclic ligands'. Journal of Inorganic Biochemistry, 241 . [DOI]
2022 McGorman, B; Fantoni, NZ; O'Carroll, S; Ziemele, A; El-Sagheer, AH; Brown, T; Kellett, A (2022) 'Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications'. Nucleic Acids Research, . [DOI]
2022 Banasiak, A.; Fantoni, N.Z.; Kellett, A.; Colleran, J. (2022) 'Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors'. Molecules, 27 . [Link] [DOI]
2022 Anna Clara Milesi Galdino; Lívia Viganor; Matheus Mendonça Pereira; Michael Devereux; Malachy McCann; Marta Helena Branquinha; Zara Molphy; Sinéad O’Carroll; Conor Bain; Georgia Menounou; Andrew Kellett; André Luis Souza dos Santos (2022) 'Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa'. Journal of Biological Inorganic Chemistry, 27 :201-213. [DOI]
2021 Fantoni NZ; Molphy Z; O'Carroll S; Menounou G; Mitrikas G; Krokidis MG; Chatgilialoglu C; Colleran J; Banasiak A; Clynes M; Roche S; Kelly S; McKee V; Kellett A; (2021) 'Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition'. Chemistry - A European Journal, 27 (3). [DOI]
2021 Hennessy, J; McGorman, B; Molphy, Z; Farrell, NP; Singleton, D; Brown, T; Kellett, A (2021) 'A Click Chemistry Approach to Targeted DNA Crosslinking with cis-Platinum(II) Modified Triplex Forming Oligonucleotides'. Angewandte Chemie (International ed. in English), 61 . [DOI]
2021 McStay, N; Slator, C; Singh, V; Gibney, A; Westerlund, F; Kellett, A (2021) 'Click and Cut: a click chemistry approach to developing oxidative DNA damaging agents'. Nucleic Acids Research, . [DOI]
2021 Fantoni, N.Z.; Molphy, Z.; O'Carroll, S.; Menounou, G.; Mitrikas, G.; Krokidis, M.G.; Chatgilialoglu, C.; Colleran, J.; Banasiak, A.; Clynes, M.; Roche, S.; Kelly, S.; McKee, V.; Kellett, A. (2021) 'Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition'. Chemistry (Weinheim an der Bergstrasse, Germany), 27 . [Link] [DOI]
2020 Lauria, T; Slator, C; McKee, V; Muller, M; Stazzoni, S; Crisp, AL; Carell, T; Kellett, A (2020) 'A Click Chemistry Approach to Developing Molecularly Targeted DNA Scissors'. Chemistry - A European Journal, . [DOI]
2020 Rochford, G.; Molphy, Z.; Kavanagh, K.; McCann, M.; Devereux, M.; Kellett, A.; Howe, O. (2020) 'Cu(ii) phenanthroline-phenazine complexes dysregulate mitochondrial function and stimulate apoptosis'. Metallomics, 12 . [Link] [DOI]
2020 Rochford, Garret and Molphy, Zara and Kavanagh, Kevin and McCann, Malachy and Devereux, Michael and Kellett, Andrew and Howe, Orla (2020) 'Cu(ii) phenanthroline–phenazine complexes dysregulate mitochondrial function and stimulate apoptosis'. 12 :65-78. [Link] [DOI]
2020 Suk, M; Haiss, A; Westphal, J; Jordan, A; Kellett, A; Kapitanov, IV; Karpichev, Y; Gathergood, N; Kummerer, K (2020) 'Design rules for environmental biodegradability of phenylalanine alkyl ester linked ionic liquids'. Green Chemistry, 22 :4498-4508. [DOI]
2020 Panattoni A; El-Sagheer AH; Brown T; Kellett A; Hocek M; (2020) 'Oxidative DNA Cleavage with Clip-Phenanthroline Triplex-Forming Oligonucleotide Hybrids'. ChemBioChem, (7):991-1000. [DOI]
2020 Fantoni, NZ; McGorman, B; Molphy, Z; Singleton, D; Walsh, S; El-Sagheer, AH; McKee, V; Brown, T; Kellett, A (2020) 'Development of Gene-Targeted Polypyridyl Triplex-Forming Oligonucleotide Hybrids'. ChemBioChem, . [DOI]
2020 Panattoni, A; El-Sagheer, AH; Brown, T; Kellett, A; Hocek, M (2020) 'Oxidative DNA Cleavage with Clip-Phenanthroline Triplex-Forming Oligonucleotide Hybrids'. ChemBioChem, 21 :991-1000. [DOI]
2020 Suk, Morten and Haiß, Annette and Westphal, Janin and Jordan, Andrew and Kellett, Andrew and Kapitanov, Illia V. and Karpichev, Yevgen and Gathergood, Nicholas and Kümmerer, Klaus (2020) 'Design rules for environmental biodegradability of phenylalanine alkyl ester linked ionic liquids'. . [Link] [DOI]
2019 Zuin Fantoni N.; Molphy Z.; Slator C.; Menounou G.; Toniolo G.; Mitrikas G.; McKee V.; Chatgilialoglu C.; Kellett A. (2019) 'Polypyridyl-Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease'. Chemistry - A European Journal, . [DOI]
2019 McStay N.; Reilly A.; Gathergood N.; Kellett A. (2019) 'Efficient DNA Condensation by a C3-Symmetric Codeine Scaffold'. ChemPlusChem, . [DOI]
2019 Kapitanov, I.V.; Jordan, A.; Karpichev, Y.; Spulak, M.; Perez, L.; Kellett, A.; Kümmerer, K.; Gathergood, N. (2019) 'Synthesis, self-assembly, bacterial and fungal toxicity, and preliminary biodegradation studies of a series of l-phenylalanine-derived surface-active ionic liquids'. Green Chemistry, 21 . [Link] [DOI]
2019 de Souza, IP; Machado, BD; de Carvalho, AB; Binatti, I; Krambrock, K; Molphy, Z; Kellett, A; Pereira-Maia, EC; Silva-Caldeira, PP (2019) 'Exploring the DNA binding, oxidative cleavage, and cytotoxic properties of new ternary copper(II) compounds containing 4-aminoantipyrine and N,N-heterocyclic co-ligands'. Journal of Molecular Structure, 1178 :18-28. [DOI]
2019 Molphy, Zara and McKee, Vickie and Kellett, Andrew (2019) 'Copper bis-Dipyridoquinoxaline Is a Potent DNA Intercalator that Induces Superoxide-Mediated Cleavage via the Minor Groove'. 24 (23). [Link] [DOI]
2019 Krokidis, Marios G. and Molphy, Zara and Efthimiadou, Eleni K. and Kokoli, Marianna and Argyri, Smaragda-Maria and Dousi, Irini and Masi, Annalisa and Papadopoulos, Kyriakos and Kellett, Andrew and Chatgilialoglu, Chryssostomos (2019) 'Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N-alkyl-acridones and N,N′-dialkyl-9,9′-biacridylidenes'. 9 (5). [Link] [DOI]
2020 Barrett, S.; De Franco, M.; Kellett, A.; Dempsey, E.; Marzano, C.; Erxleben, A.; Gandin, V.; Montagner, D. (2020) 'Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes'. Journal of Biological Inorganic Chemistry, 25 . [Link] [DOI]
2019 Kellett, A.; Molphy, Z.; Slator, C.; McKee, V.; Farrell, N.P. (2019) 'Molecular methods for assessment of non-covalent metallodrug-DNA interactions'. Chemical Society Reviews, 48 . [Link] [DOI]
2019 I.V. Kapitanov; A. Jordan; Y. Karpichev; M. Spulak; L. Perez; A. Kellett, K. Kümmerer; N. Gathergood (2019) 'Synthesis, self-assembly, bacterial and fungal toxicity, and preliminary biodegradation studies of a series of L-phenylalanine-derived surface-active ionic liquids'. Green Chemistry, 21 :1777-1794. [DOI]
2019 Molphy Z.; McKee V.; Kellett A. (2019) 'Copper bis-Dipyridoquinoxaline Is a Potent DNA Intercalator that Induces Superoxide-Mediated Cleavage via the Minor Groove'. Molecules, 24 (23). [DOI]
2019 Krokidis, M.G.; Molphy, Z.; Efthimiadou, E.K.; Kokoli, M.; Argyri, S.M.; Dousi, I.; Masi, A.; Papadopoulos, K.; Kellett, A.; Chatgilialoglu, C. (2019) 'Assessment of dna topoisomerase i unwinding activity, radical scavenging capacity, and inhibition of breast cancer cell viability of n-alkylacridones and n,n′-dialkyl-9,9′-biacridylidenes'. Biomolecules, 9 . [Link] [DOI]
2019 Ude, Z.; Kavanagh, K.; Twamley, B.; Pour, M.; Gathergood, N.; Kellett, A.; Marmion, C.J. (2019) 'A new class of prophylactic metallo-antibiotic possessing potent anti-cancer and anti-microbial properties'. Dalton Transactions, 48 . [Link] [DOI]
2018 Toniolo G.; Louka M.; Menounou G.; Fantoni N.; Mitrikas G.; Efthimiadou E.; Masi A.; Bortolotti M.; Polito L.; Bolognesi A.; Kellett A.; Ferreri C.; Chatgilialoglu C. (2018) '[Cu(TPMA)(Phen)](ClO4)2: Metallodrug Nanocontainer Delivery and Membrane Lipidomics of a Neuroblastoma Cell Line Coupled with a Liposome Biomimetic Model Focusing on Fatty Acid Reactivity'. Acs Omega, 3 (11):15952-15965. [DOI]
2018 Slator, C; Molphy, Z; Mckee, V; Long, C; Brown, T; Kellett, A (2018) 'Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination'. Nucleic Acids Research, 46 :2733-2750. [DOI]
2018 McGivern T.; Slator C.; Kellett A.; Marmion C. (2018) 'Innovative DNA-Targeted Metallo-prodrug Strategy Combining Histone Deacetylase Inhibition with Oxidative Stress'. Molecular Pharmaceutics, . [DOI]
2018 Molphy, Z.; Montagner, D.; Bhat, S.S.; Slator, C.; Long, C.; Erxleben, A.; Kellett, A. (2018) 'A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage'. Nucleic Acids Research, 46 . [Link] [DOI]
2018 Rochford G.; Molphy Z.; Browne N.; Surlis C.; Devereux M.; McCann M.; Kellett A.; Howe O.; Kavanagh K. (2018) 'In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes'. Journal of Inorganic Biochemistry, 186 :135-146. [DOI]
2017 McStay, N; Molphy, Z; Coughlan, A; Cafolla, A; McKee, V; Gathergood, N; Kellett, A (2017) 'C-3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, 45 :527-540. [DOI]
2017 McStay, N; Molphy, Z; Gathergood, N; Kellett, A (2017) 'OPIOID ARCHITECTURES AS NEW DNA BINDING MOLECULES'. Symmetry-Culture And Science, 28 :195-198.
2017 Slator, C.; Molphy, Z.; McKee, V.; Kellett, A. (2017) 'Triggering autophagic cell death with a di-manganese(II) developmental therapeutic'. Redox Biology, 12 . [Link] [DOI]
2017 McStay, N.; Molphy, Z.; Gathergood, N.; Kellett. A. (2017) 'Opioid architectures as new DNA binding molecules'. Symmetry, 28 (24):195-198. [Link] http://journal-scs.symmetry.hu/content-pages/volume-28-number-2-pages-161-240-2017/
2016 Terzidis, M.A.; Prisecaru, A.; Molphy, Z.; Barron, N.; Randazzo, A.; Dumont, E.; Krokidis, M.G.; Kellett, A.; Chatgilialoglu, C. (2016) 'Radical-induced purine lesion formation is dependent on DNA helical topology'. Free Radical Research, 50 . [Link] [DOI]
2016 McStay N; Molphy Z; Coughlan A; Cafolla A; McKee V; Gathergood N; Kellett A; (2016) 'C3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, . [DOI]
2016 Kelly, P.S.; McSweeney, S.; Coleman, O.; Carillo, S.; Henry, M.; Chandran, D.; Kellett, A.; Bones, J.; Clynes, M.; Meleady, P.; Barron, N. (2016) 'Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics'. Biotechnology Progress, 32 . [Link] [DOI]
2016 Thornton L.; Dixit V.; Assad L.; Ribeiro T.; Queiroz D.; Kellett A.; Casey A.; Colleran J.; Pereira M.; Rochford G.; McCann M.; O'Shea D.; Dempsey R.; McClean S.; Kia A.; Walsh M.; Creaven B.; Howe O.; Devereux M. (2016) 'Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity'. Journal of Inorganic Biochemistry, 159 :120-132. [DOI]
2016 Viganor, L.; Galdino, A.C.M.; Nunes, A.P.F.; Santos, K.R.N.; Branquinha, M.H.; Devereux, M.; Kellett, A.; McCann, M.; Santos, A.L.S. (2016) 'Anti-Pseudomonas aeruginosa activity of 1,10-phenanthroline-based drugs against both planktonic- and biofilm-growing cells'. Journal of Antimicrobial Chemotherapy, 71 . [Link] [DOI]
2016 Kelly, PS; McSweeney, S; Coleman, O; Carillo, S; Henry, M; Chandran, D; Kellett, A; Bones, J; Clynes, M; Meleady, P; Barron, N (2016) 'Process-Relevant Concentrations of the Leachable bDtBPP Impact Negatively on CHO Cell Production Characteristics'. Biotechnology Progress, 32 :1547-1558. [DOI]
2016 Slator C., Barron N., Howe O., Kellett A. (2016) '[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction'. ACS chemical biology, 11 :159-171. [DOI]
2015 Molphy Z., Slator C., Chatgilialoglu C., and Kellett A. (2015) 'DNA Oxidation Profiles of Copper Phenanthrene Chemical Nucleases'. FRONTIERS IN CHEMISTRY, 3 :1-9. [Link] [DOI]
2015 Fantoni N.; Lauria T.; Kellett A. (2015) 'Genome Engineering with Synthetic Copper Nucleases'. Synlett, 26 (19):2623-2626. [DOI]
2015 Larragy R.; Fitzgerald J.; Prisecaru A.; McKee V.; Leonard P.; Kellett A. (2015) 'Protein engineering with artificial chemical nucleases'. Chemical Communications, 51 (65):12908-12911. [DOI]
2015 Larragy, R; Fitzgerald, J; Prisecaru, A; Mckee, V; Leonard, P; Kellett, A (2015) 'Protein engineering with artificial chemical nucleases'. Chemical Communications, 51 :12908-12911. [DOI]
2014 Molphy, Z.; Prisecaru, A.; Slator, C.; Barron, N.; McCann, M.; Colleran, J.; Chandran, D.; Gathergood, N.; Kellett, A. (2014) 'Copper phenanthrene oxidative chemical nucleases'. Inorganic Chemistry, 53 . [Link] [DOI]
2014 Prisecaru A.; Molphy Z.; Kipping R.; Peterson E.; Qu Y.; Kellett A.; Farrell N. (2014) 'The phosphate clamp: Sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes'. Nucleic Acids Research, 42 (22):13474-13487. [DOI]
2013 Prisecaru, A.; McKee, V.; Howe, O.; Rochford, G.; McCann, M.; Colleran, J.; Pour, M.; Barron, N.; Gathergood, N.; Kellett, A. (2013) 'Regulating bioactivity of Cu2+ Bis-1,10-phenanthroline artificial metallonucleases with sterically functionalized pendant carboxylates'. Journal of Medicinal Chemistry, 56 . [Link] [DOI]
2013 McCann M., McGinley J., Ni K., O'Connor M., Kavanagh K., McKee V., Colleran J., Devereux M., Gathergood N., Barron N., Prisecaru A. and Kellett A. (2013) 'A new phenanthroline-oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction'. CHEMICAL COMMUNICATIONS (PRINT), 49 :2341-2343. [DOI]
2013 Mc Cann, M.; Mc Ginley, J.; Ni, K.; O’connor, M.; Kavanagh, K.; Mc Kee, V.; Colleran, J.; Devereux, M.; Gathergood, N.; Barron, N.; Prisecaru, A.; Kellett, A. (2013) 'A new phenanthroline–oxazine ligand: Synthesis, coordination chemistry and atypical DNA binding interaction'. Chemical Communications, 49 . [Link] [DOI]
2013 McCann M.; Curran R.; Ben-Shoshan M.; McKee V.; Devereux M.; Kavanagh K.; Kellett A. (2013) 'Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles'. Polyhedron, 56 :180-188. [DOI]
2013 Kellett A.; Prisecaru A.; Slator C.; Molphy Z.; McCann M. (2013) 'Metal-based antimicrobial protease inhibitors'. Current Medicinal Chemistry, 20 (25):3134-3151. [DOI]
2012 McCann M.; Santos A.; Da Silva B.; Romanos M.; Pyrrho A.; Devereux M.; Kavanagh K.; Fichtner I.; Kellett A. (2012) 'In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(ii) and silver(i) complexes'. Toxicology Research, 1 (1):47-54. [DOI]
2012 McCann M.; Curran R.; Ben-Shoshan M.; McKee V.; Tahir A.; Devereux M.; Kavanagh K.; Creaven B.; Kellett A. (2012) 'Silver(i) complexes of 9-anthracenecarboxylic acid and imidazoles: Synthesis, structure and antimicrobial activity'. Dalton Transactions, 41 (21):6516-6527. [DOI]
2012 O'Connor, M.; Kellett, A.; McCann, M.; Rosair, G.; McNamara, M.; Howe, O.; Creaven, B.S.; McClean, S.; Foltyn-Arfa Kia, A.; O'Shea, D.; Devereux, M. (2012) 'Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines'. Journal of Medicinal Chemistry, 55 . [Link] [DOI]
2012 Kellett A.; McCann M.; Howe O.; O'Connor M.; Devereux M. (2012) 'DNA cleavage reactions of the dinuclear chemotherapeutic agent copper(II) bis-1,10- Phenanthroline terephthalate'. International Journal of Clinical Pharmacology and Therapeutics, 50 (1):79-81. [DOI]
2012 Prisecaru, A.; Devereux, M.; Barron, N.; McCann, M.; Colleran, J.; Casey, A.; McKee, V.; Kellett, A. (2012) 'Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(μ-terephthalate)(1,10-phen)4]2+n'. Chemical Communications, 48 . [Link] [DOI]
2012 McCann, M.; Kellett, A.; Kavanagh, K.; Devereux, M.; Santos, A.L.S. (2012) 'Deciphering the antimicrobial activity of phenanthroline chelators'. Current Medicinal Chemistry, 19 . [Link]
2012 Kellett, A.; Howe, O.; O'Connor, M.; McCann, M.; Creaven, B.S.; McClean, S.; Foltyn-Arfa Kia, A.; Casey, A.; Devereux, M. (2012) 'Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2′-dipyridyl'. Free Radical Biology and Medicine, 53 . [Link] [DOI]
2012 Santos, A.L.S.; Sodré, C.L.; Valle, R.S.; Silva, B.A.; Abi-Chacra, E.A.; Silva, L.V.; Souza-Gonçalves, A.L.; Sangenito, L.S.; Gonçalves, D.S.; Souza, L.O.P.; Palmeira, V.F.; D'Avila-Levy, C.M.; Kneipp, L.F.; Kellett, A.; McCann, M.; Branquinha, M.H. (2012) 'Antimicrobial action of chelating agents: Repercussions on the microorganism development, virulence and pathogenesis'. Current Medicinal Chemistry, 19 . [Link]
2011 Kellett A., OConnor M., McCann M., Howe O., Casey A., McCarron P., McNamara M., Kennedy S., May D. D., Skell P. S., OShea D., Devereux M. (2011) 'Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development'. MEDICAL CHEMISTRY COMMUNICATIONS, 2 :569-676. [DOI]
2011 Kellett A., OConnor M., McCann M., McNamara M., Lynch P., Rosair G., McKee V., Creaven B., Walsh M., McClean S., Foltyn A., OShea D., Howe O., Devereux M. (2011) 'Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with self-activating metallo-nuclease and DNA binding properties'. 40 :1024-1027.
2010 Kellett, A., Rosair G., Devereux M., McNamara M., McCann M. (2010) 'Hexakis(prop-2-enamide)copper(II) bis(perchlorate) and hexakis(prop-2-enamide)manganese(II) bis(perchlorate)'. ACTA CRYSTALLOGRAPHICA SECTION C, 66 :M358-M362.
2010 Creaven B. S., Czeglédi E., Devereux M., Enyedy É. A., Foltyn-Arfa Kia A., Karcz D., Kellett A., McClean S., Nagy N. V., Noble A., Rockenbauer A.,Szabó-Plánka T., Walsh M. (2010) 'Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands'. 39 :10854-10865.
2009 Creaven B. S., Devereux M., Karcz D., Kellett A., McCann M., Noble A., Walsh M. (2009) 'Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity'. Journal of Inorganic Biochemistry, 103 :1196-1203.
2007 Devereux M., O'Shea D., Kellett A., McCann M., Walsh M., Egan D., Deegan C., Kgdziora K., Rosair G., Mulller-Bunz H. (2007) 'Synthesis, X-ray crystal structures and biomimetic and anticancer activities of novel copper(II)benzoate complexes incorporating 2-(4'-thiazolyl)benzimidazole (thiabendazole), 2-(2-pyridyl)benzimidazole and 1,10-phenanthroline as chelating nitrogen donor ligands'. Journal of Inorganic Biochemistry, 101 :881-892.
2007 Devereux M., O'Shea D., O'Connor M., Grehan H., Connor G., McCann M., Rosair G., Lyng F., Kellett A., Walsh M., Egan D., Thati B. (2007) 'Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: X-ray crystal structures of [Cu(BZA)(2)(bipy)(H2O)], [Cu(SalH)(2)(BZDH)(2)] and [Cu(CH3COO)(2)(5,6-DMBZDH)(2)] (SalH(2) =salicylic acid; BZAH = benzoic acid; BZDH = benzimidazole and 5,6-DMBZDH=5,6-dimethylbenzimidazole)'. Polyhedron, 26 :4073-4084.
2006 Devereux M., McCann M., O'Shea D., O'Connor M., Kiely E., McKee V., Naughton D., Fisher A., Kellett A., Walsh M., Egan D., Deegan C. (2006) 'Synthesis, superoxide dismutase mimetic and anticancer activities of metal complexes of 2,2-dimethylpentanedioic acid(2dmepdaH(2)) and 3,3-dimethylpentanedioic acid(3dmepdaH(2)): X-ray crystal structures of [Cu(3dmepda)(bipy)](2)center dot 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2)center dot 4EtOH (bipy=2,2 ' bipyridine)'. Bioinorganic Chemistry and Applications, 80283 .
2021 Galdino, ACM; Viganor, L; Pereira, MM; Devereux, M; McCann, M; Branquinha, MH; Molphy, Z; O'Carroll, S; Bain, C; Menounou, G; Kellett, A; Dos Santos, ALS (2021) 'Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa'. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, . [DOI]
2017 McStay, N; Molphy, Z; Coughlan, A; Cafolla, A; McKee, V; Gathergood, N; Kellett, A (2017) 'C-3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, 45 :527-540. [DOI]
2017 Slator, C; Molphy, Z; Mckee, V; Kellett, A (2017) 'Triggering autophagic cell death with a di-manganese(II) developmental therapeutic'. Redox Biology, 12 :150-161. [DOI]
2016 Slator, C.; Barron, N.; Howe, O.; Kellett, A. (2016) 'Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction'. ACS chemical biology, 11 . [Link] [DOI]
2016 McStay N; Molphy Z; Coughlan A; Cafolla A; McKee V; Gathergood N; Kellett A; (2016) 'C3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, . [DOI]
2016 McStay N; Molphy Z; Coughlan A; Cafolla A; McKee V; Gathergood N; Kellett A; (2016) 'C3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, . [DOI]
2016 Terzidis, MA; Prisecaru, A; Molphy, Z; Barron, N; Randazzo, A; Dumont, E; Krokidis, MG; Kellett, A; Chatgilialoglu, C (2016) 'Radical-induced purine lesion formation is dependent on DNA helical topology'. Free Radical Research, 50 :91-101. [DOI]
2016 McStay N; Molphy Z; Coughlan A; Cafolla A; McKee V; Gathergood N; Kellett A; (2016) 'C3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, . [DOI]
2016 McStay N; Molphy Z; Coughlan A; Cafolla A; McKee V; Gathergood N; Kellett A; (2016) 'C3-symmetric opioid scaffolds are pH-responsive DNA condensation agents'. Nucleic Acids Research, . [DOI]
2015 Larragy, R; Fitzgerald, J; Prisecaru, A; Mckee, V; Leonard, P; Kellett, A (2015) 'Protein engineering with artificial chemical nucleases'. Chemical Communications, 51 :12908-12911. [DOI]
2015 Larragy R., Fitzgerald J., Prisecaru A., McKee V., Leonard P. and Kellett A. (2015) 'Protein engineering with artificial chemical nucleases'. CHEMICAL COMMUNICATIONS (PRINT), 51 :12908-12911. [DOI]
2015 Molphy, Z.; Slator, C.; Chatgilialoglu, C.; Kellett, A. (2015) 'DNA oxidation profiles of copper phenanthrene chemical nucleases'. FRONTIERS IN CHEMISTRY, 3 . [Link] [DOI]
2015 Fantoni N., Lauria T., Kellett A. (2015) 'Genome Engineering with Synthetic Copper Nucleases'. in press . [DOI]
2014 Molphy Z., Prisecaru A., Slator C., Barron, N., McCann M., Colleran J., Chandran D., Gathergood N. and Kellett A. (2014) 'Copper Phenanthrene Oxidative Chemical Nucleases'. Inorganic Chemistry, 53 :5392-5404.
2014 Prisecaru A., Molphy Z., Kipping R.G., Peterson E.J., Qu Y., Kellett A., and Farrell N.P. (2014) 'The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes'. 42 :13474-87.
2013 Kellett, A; Prisecaru, A; Slator, C; Molphy, Z; McCann, M (2013) 'Metal-Based Antimicrobial Protease Inhibitors'. Current Medicinal Chemistry, 20 :3134-3151.
2013 Kellett A., Prisecaru A., Slator C., Molphy Z., McCann M. (2013) 'Metal-Based Antimicrobial Protease Inhibitors'. Current Medicinal Chemistry, 20 :3134-3151.
2013 Prisecaru A., Mckee V., Howe O., Rochford G., McCann M, Colleran J., Barron N., Pour M., Gathergood N. and Kellett A. (2013) 'Regulating Bioactivity of Cu2+ Bis-1,10-Phenanthroline Artificial Metallonucleases with Sterically Functionalised Pendant Carboxylates'. Journal of Medicinal Chemistry, 56 :8599-8615.
2013 McCann M., Curran R., Ben-Shoshana M., McKee V., Devereux M., Kavanagh K., Kellett A. (2013) 'Synthesis, Structure and Biological Activity of Silver(I) Complexes of Substituted Imidazoles'. Polyhedron, 56 :180-188.
2012 Prisecaru A., Devereux M., Barron N., McCann M., Colleran J., Casey A., McKee V. and Kellett A. (2012) 'Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(terephthalate)(1,10-phen)4]2+'. CHEMICAL COMMUNICATIONS (PRINT), 48 :6906-6908. [DOI]
2012 McCann M., Santos A., da Silva B., Romanos M., Pyrrho A., Devereux M., Kavanagh K., Fichtner I. and Kellett A. (2012) 'In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(II) and silver(I) complexes'. Toxicology Research, 1 :47-54.
2012 O'Connor M., Kellett A., McCann M., Rosair G., McNamara M., Howe O., Creaven B., McClean S., Foltyn-Arfa Kia A., O'Shea D. and Devereux M. (2012) 'Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities exhibit low toxicity and display promising chemotherapeutic potential with fast acting in-vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines'. Journal of Medicinal Chemistry, 55 :1957-1968.
2012 André L.S. Santos, Cátia L. Sodré, Roberta S. Valle, Bianca A. Silva, Érika A. Abi-chacra, Lívia V. Silva, Ana Luiza Souza-Gonçalves, Leandro S. Sangenito, Diego S. Gonçalves, Lucieri O.P. Souza, Vanila F. Palmeira, Claudia M. dAvila-Levy, Lucimar F. Kneipp, Andrew Kellett, Malachy McCann, Marta H. Branquinha (2012) 'Antimicrobial Action of Chelating Agents: Repercussions on the Microorganism Development, Virulence and Pathogenesis'. Current Medicinal Chemistry, 19 :2715-2737.
2012 Andrew Kellett, Malachy McCann, Orla Howe, Mark OConnor and Michael Devereux (2012) 'DNA Cleavage Reactions of the Dinuclear Chemotherapeutic Agent Copper(II) Bis-1,10-Phenanthroline Terephthalate'. International Journal of Clinical Pharmacology and Therapeutics, 50 :79-81.
2012 Kellett A., Howe O., OConnor M., McCann M., Creaven B., McClean S., Foltyn-Arfa Kia A., Casey A. and Devereux M. (2012) 'Radical Induced DNA Damage by Cytotoxic Square-Planar Copper(II) Complexes Incorporating o-Phthalate and 1,10-Phenanthroline or 2,2'-Dipyridyl'. Free Radical Biology and Medicine, 53 :564-576. [DOI]
2012 Malachy McCann, Andrew Kellett, Kevin Kavanagh, Michael Devereux and André L. S. Santos (2012) 'Deciphering the Antimicrobial Activity of Phenanthroline Chelators'. Current Medicinal Chemistry, 19 :2703-2714.
2012 McCann M., Curran R., Ben-Shoshan M., McKee V., Tahir A., Devereux M., Kavanagh K., Creaven B. and Kellett A. (2012) 'Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity'. 41 :6516-6527.
2011 Kellett, A.; O'Connor, M.; McCann, M.; Howe, O.; Casey, A.; McCarron, P.; Kavanagh, K.; McNamara, M.; Kennedy, S.; May, D.D.; Skell, P.S.; O'Shea, D.; Devereux, M. (2011) 'Water-soluble bis(1,10-phenanthroline) octanedioate Cu 2+ and Mn 2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: Promising leads for chemotherapeutic drug development'. MedChemComm, 2 . [Link] [DOI]

Conference Publication

Year Publication
2018 Rochford, G; Molphy, Z; Browne, N; Surlis, C; Devereux, M; McCann, M; Kellett, A; Howe, O; Kavanagh, K (2018) JOURNAL OF INORGANIC BIOCHEMISTRY In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes [DOI]

Conference Contribution

Year Publication
2016 Andrew Kellett (2016) TBSI Chemistry Seminar Series Metallodrugs as Inducers or Inhibitors of Chemical Nuclease Activity Trinity College Dublin, 25/02/2016-25/02/2016.
2015 Kellett A. (2015) Wolfson CRL Chemical Biology Seminar Series Metallodrugs as inducers or inhibitors of chemical nuclease activity University of Oxford, 18/11/2015-18/11/2015.
2015 Kellett A. (2015) 13th International Symposium on Applied Bioinorganic Chemistry (ISABC13) Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity NUI Galway, 12/06/2015-15/06/2015.
2015 Kellett A. (2015) Invited Lecture Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity NUI Galway, 05/03/2015-05/03/2015.
2014 Kellett A. (2014) Brazilian Meeting on Inorganic Chemistry (BMIC) XVII, Invited Talk Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity Araxá, Brazil, 10/08/2014-14/08/2014.
2014 Kellett, A. (2014) Invited talk Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity Universidade Federal do Rio de Janeiro, Brazil, 08/08/2014-08/08/2014.
2014 Kellett, Andrew (2014) Invited Talk Copper(II) Oxidative Chemical Nucleases Department of Chemistry, Loughborough University, UK, 29/01/2014-29/01/2014.
2014 Kellett, A. (2014) EUCHEM Conference on Organic Free Radicals Metallodrugs as Inducers and Inhibitors of Chemical Nuclease Activity Prague, 29/06/2014-04/07/2014.
2014 Kellett A. (2014) COST Action CM1201: Biomimetic Radical Chemistry, WG4/WG1 Inter-Working Group Meeting NCI‐60 chemotherapeutic action of copper metallointercalators bear apoptotic hallmarks of hydroxyl radical induced death Puerto de la Cruz, Tenerife, Spain, 01/10/2014-03/10/2014.
2014 Kellett, A. (2014) Invited talk Deciphering the Antimicrobial Action of Copper Phenazines through Proteomic Analysis Universidade Federal do Rio de Janeiro, Brazil, 07/08/2014-07/08/2014.
2013 Andrew Kellett (2013) COST Action CM1201: Biomimetic Radical Chemistry, 1st Working Group Meeting (WG 2: Models of DNA Damage and Consequences) Copper Phenanthrene Oxidative Chemical Nucleases Athens, Greece, 17/10/2013-19/10/2013.
2012 Andrew Kellett (2012) 2012 Symposium on Inorganic Chemistry in Ireland Copper Metallo-Nucleases in Cancer Chemotherapy National University of Ireland, Galway, 07/12/2012-.
2011 Andrew Kellett (2011) Chemistry Lecture Seminar Series DNA activation by phenanthroline dicarboxylate complexes: new frontiers for metal-based drugs? Dublin City University, 13/04/2011-.
2011 Andrew Kellett, Michael Devereux, Malachy McCann, Mark OConnor, Pauraic McCarron, Alan Casey, and Orla Howe (2011) Central European Society for Anticancer Drug Research (CESAR) Annual Meeting DNA activation by phenanthroline dicarboxylate complexes: new frontiers for metal-based drugs? Greifswald University Germany, 16/06/2011-18/06/2011.
2010 Pauraic Mc Carron, Malachy McCann, Andrew Kellett, Michael Devereux (2010) 62nd Irish Universities Chemistry Research Colloquium Synthesis and Chemotherapeutic Potential of Manganese(II) 1,10-Phenanthroline/Phthalate Complexes Queens University Belfast, 01/07/2010-02/07/2010.
2010 Andrew Kellett, Michael Devereux, Mary McNamara, Malachy McCann, Mark OConnor, Orla Howe, Alan Casey, Sean Kennedy, Vickie McKee, Georgina Rosair (2010) 2nd Symposium on Inorganic Chemistry in Ireland Bis-Phenanthroline Copper(II) Complexes of Aromatic and Aliphatic Dicarboxylates are Potent In Vitro Antitumour Agents with ‘Self-Activating’ Metallo-Nuclease & DNA Binding Properties Queens University Belfast, 17/09/2010-.
2009 A. Kellett, M. Devereux, M. McNamara, M. McCann, M. OConnor, D. OShea, G. Rosair, V. McKee, M. Walsh and O. Howe (2009) Irish Institute of Metal Based Drugs (IIMBD) Symposium Anti-Tumor Potential & Mechanistic Studies of New Copper(II) Complexes Dublin Institute of Technology, 26/11/2009-.
2009 Andrew Kellett, Michael Devereux, Mary McNamara, Malachy McCann, Mark OConnor, Orla Howe, Alan Casey, Sean Kennedy, Vickie McKee, Georgina Rosair (2009) NUI Maynooth Chemistry Seminar Series Anti-Tumor Potential & Mechanistic Studies of New Copper(II) Complexes National University of Ireland Maynooth, 14/10/2009-.
2007 Michael Devereux, Denis OShea, Mark OConnor, Helen Grehan, Gavin Connor, Malachy McCann, Georgina Rosair, Fiona Lyng, Andrew Kellett, Maureen Walsh, Denise Egan and Bhumika Thati (2007) 59th Irish Universities Chemistry Research Colloquium Copper(II) Superoxide Dismutase Mimetics as Potential Anticancer Drugs Dublin City University, 13/06/2007-15/06/2007.
2006 McCann M., Rowan R., Devereux D., Kellett A., Hilger R. (2006) Central European Society for Anticancer Drug Research (CESAR) Annual Meeting Silver Bullets in Anticancer Chemotherapy University Hospital, Essen, Germany, 12/07/2006-.
2005 Andrew Kelett, Maureen Walsh, Michael Devereux, Helge Muller-Bunz, Vickie McKee and Georgina Rosair (2005) 3nd Annual Science Research Day ITTD Synthesis, characterisation and biological activity of copper(II) carboxylates incorporating selective N-donor ligands Institute of Technology Tallaght Dublin, 31/03/2005-.
2004 Andrew Kellett, Michael Devereux, Maureen Walsh, Bernie Creaven, Malachy McCann, Denis O'Shea, Helge Muller-Bunz (2004) 8th annual science and computing research colloquium Novel Cu(II) Benzimidazole Complexes for the treatment of Candida Albicans Related Infections Waterford Institute of Technology, 26/05/2004-28/05/2004.
2004 Andrew Kellett, Michael Devereux, Malachy McCann, Denis O'Shea, Maureen Walsh, Bernie Creaven, Helge Muller-Bunz (2004) 56th Irish Universities Chemistry Research Colloquium Copper(II) benzoate complexes incorporating benzimidazole ligands: Synthesis, structures and antifungal activity University of Limerick, 23/06/2004-25/06/2004.

Abstract

Year Publication
2017 McGivern, T; Ude, Z; Kenny, R; Kellett, A; Marmion, CJ (2017) Rational design and development of metallodrug chemotypes for therapeutic exploitation. NEW YORK: ABST
2017 Montagner, D; Erxleben, A; Miguel, PS; Kavanagh, K; Kellett, A (2017) Estrogens-functionalized metal complexes: selective anticancer and antibacterial activity. NEW YORK: ABST

Review Articles

Year Publication
2019 Kellett, A; Molphy, Z; Slator, C; McKee, V; Farrell, NP (2019) Molecular methods for assessment of non-covalent metallodrug-DNA interactions. CAMBRIDGE: REV [DOI]

Other Publication

Year Publication
2023 O'Halloran, S.; Pandit, A.; Heise, A.; Kellett, A. (2023) Two-Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies. [Link] [DOI]
2021 Fantoni, N.Z.; Brown, T.; Kellett, A. (2021) DNA-Targeted Metallodrugs: An Untapped Source of Artificial Gene Editing Technology. [Link] [DOI]
Certain data included herein are derived from the © Web of Science (2023) of Clarivate. All rights reserved.

Research Interests


  • Design of inorganic materials as molecular scissors for DNA excision.
  • Nucleic acid binding interactions.
  • Free radical chemical biology at the DNA interface.
  • Metallo-cytotoxic drug design and mechanism.
  • Coordinator of the multimillion EU funded Marie Curie ITN research programme, ClickGene: Click Chemistry for Future Gene Therapies to Benefit Citizens, Researchers and Industry (H2020 - MSCA - ITN). www.clickgene.eu

Funding Opportunities

Irish Research Council

Link: www.research.ie

Postgraduate and Postdoctoral scholarship funding opportunities are regularly available through the IRC. Suitable candidates wishing to join this group are welcome to apply for an IRC scholarship, for more information please contact me by email.

Modules Coordinated

Term Title Subject
2022 Inorganic Chemistry Laboratory CS254
2022 Computational and Inorganic Chemistry CS308
2022 Inorganic & Physical Chemistry Lab CS260
2022 Advanced Medicinal Chemistry CS414
2022 Medicinal Chemistry CS311
2022 Advanced Inorganic Chemistry CS406