Jiafu Wang
DR
Dr. Jiafu Wang was
awarded his PhD by Wuhan University in 1999 and recruited immediately as a
lecturer by the Institute of Life Sciences at the same University. Within one
year, he successfully obtained two basic research grants from prestigious Government
Funding Bodies, the National
Natural Science Foundation of China and the Ministry of Education of China,
respectively. To enhance research career opportunities, in 2000 Jiafu joined the neuroscience
research group in Imperial College London as a post-doctoral researcher. Three
years later, he joined the International Centre for Neurotherapeutics newly established in Dublin City University. In 2010
Jiafu was appointed as an Assistant Professor in Neurotherapeutics in Faculty of Science and
Health (permanent position). Dr. Wang is a Molecular Biologist/Protein Engineer, co-inventor of a number of international patents, awardee of several SFI grants, and major contributor of awards from Higher Education Authority (HEA), Enterprise Ireland, International Pharmaceutical Companies.
Peer Reviewed Journal
| Year | Publication | |
|---|---|---|
| 2023 | Zhang, W.; Chen, W.; Shan, C.; Wang, R.; Li, L.; Wang, J.; Meng, J. (2023) 'IL-13 Activates Cutaneous Schwann Cells to Promote CCL7-Dependent Pruritic Signaling in Atopic Dermatitis'. Journal of Investigative Dermatology, 143 . [Link] [DOI] | |
| 2023 | Belinskaia, Mariia; Wang, Jiafu; Kaza, Seshu Kumar; Antoniazzi, Caren; Zurawski, Tomas; Dolly, J. Oliver; Lawrence, Gary W. (2023) 'Bipartite Activation of Sensory Neurons by a TRPA1 Agonist Allyl Isothiocyanate Is Reflected by Complex Ca2+ Influx and CGRP Release Patterns: Enhancement by NGF and Inhibition with VAMP and SNAP-25 Cleaving Botulinum Neurotoxins'. International Journal of Molecular Sciences, 24 (2). [DOI] | |
| 2023 | Wang, R; Dai, X; Chen, W; Wang, J; Wang, H; Yan, X; Zhang, W; Fan, Q; Li, L; Wang, J; Meng, J (2023) 'Matrix Metalloproteinase 9 Plays a Crucial Role in Inflammation and Itch in Allergic Contact Dermatitis by Regulating Toll-Like Receptor 2/1 Signaling'. The Journal of investigative dermatology, . [DOI] | |
| 2023 | Yang, H; Zhu, R; Zhang, W; Chen, W; Yan, X; Shan, C; Xue, S; Wang, R; Dai, X; Wang, J; Larkin, C; Wang, J; Meng, J (2023) 'Urotensin II/GPR14 Pathway Regulates Chronic Itch in Mice'. The Journal of investigative dermatology, 143 (12). [DOI] | |
| 2023 | Dai, X.; Li, L.; Yan, X.; Fan, Q.; Wang, R.; Zhang, W.; Chen, W.; Liu, Y.; Meng, J.; Wang, J. (2023) 'Myeloid Vamp3 deletion attenuates CFA-induced inflammation and pain in mice via ameliorating macrophage infiltration and inflammatory cytokine production'. Frontiers in Immunology, 14 . [Link] [DOI] | |
| 2023 | Li, Y; Chen, W; Zhu, X; Mei, H; Steinhoff, M; Buddenkotte, J; Wang, J; Zhang, W; Li, Z; Dai, X; Shan, C; Wang, J; Meng, J (2023) 'Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27-Driven Itch Pathway'. The Journal of investigative dermatology, . [DOI] | |
| 2022 | Xue, S.; Zhu, R.; Chen, W.; Yang, H.; Wang, J.; Meng, J. (2022) 'Inhibiting Keratinocyte-Derived Signal Transducer and Activator of Transcription 6 Improved Atopic Dermatitis in Mice'. Journal of Investigative Dermatology, 142 . [Link] [DOI] | |
| 2022 | Lu, Z; Xiao, S; Chen, W; Zhu, R; Yang, H; Steinhoff, M; Li, Y; Cheng, W; Yan, X; Li, L; Xue, S; Larkin, C; Zhang, W; Fan, Q; Wang, R; Wang, J; Meng, J (2022) 'IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis'. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36 (6). [DOI] | |
| 2022 | Zhu, R; Yang, H; Xue, S; Fan, Q; Zhang, W; Wang, R; Chen, W; Li, L; Wang, J; Meng, J (2022) 'Intervening GSK3 Signaling Attenuates Cutaneous Inflammation and Itch in Mice: Implication for Future Therapeutic Development'. The Journal of investigative dermatology, 143 (2). [DOI] | |
| 2022 | Chen, W.; Li, Y.; Steinhoff, M.; Zhang, W.; Buddenkotte, J.; Buhl, T.; Zhu, R.; Yan, X.; Lu, Z.; Xiao, S.; Wang, J.; Meng, J. (2022) 'The PLAUR signaling promotes chronic pruritus'. FASEB Journal, 36 . [Link] [DOI] | |
| 2021 | Larkin, C.; Chen, W.; Szabó, I.L.; Shan, C.; Dajnoki, Z.; Szegedi, A.; Buhl, T.; Fan, Y.; O'Neill, S.; Walls, D.; Cheng, W.; Xiao, S.; Wang, J.; Meng, J. (2021) 'Novel insights into the TRPV3-mediated itch in atopic dermatitis'. Journal of Allergy and Clinical Immunology, 147 . [Link] [DOI] | |
| 2021 | Wang, W.; Kong, M.; Dou, Y.; Xue, S.; Liu, Y.; Zhang, Y.; Chen, W.; Li, Y.; Dai, X.; Meng, J.; Wang, J. (2021) 'Selective expression of a snare-cleaving protease in peripheral sensory neurons attenuates pain-related gene transcription and neuropeptide release'. International Journal of Molecular Sciences, 22 . [Link] [DOI] | |
| 2021 | Xiao, S.; Lu, Z.; Steinhoff, M.; Li, Y.; Buhl, T.; Fischer, M.; Chen, W.; Cheng, W.; Zhu, R.; Yan, X.; Yang, H.; Liu, Y.; Dou, Y.; Wang, W.; Wang, J.; Meng, J. (2021) 'Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis'. Brain, Behavior, and Immunity, 98 . [Link] [DOI] | |
| 2019 | Meng, J.; Wang, J.; Buddenkotte, J.; Buhl, T.; Steinhoff, M. (2019) 'Role of SNAREs in Atopic Dermatitis–Related Cytokine Secretion and Skin-Nerve Communication'. Journal of Investigative Dermatology, 139 . [Link] [DOI] | |
| 2019 | Tang, M; Meng, J; Wang, J (2019) 'New Engineered-Botulinum Toxins Inhibit the Release of Pain-Related Mediators'. International Journal of Molecular Sciences, 21 (1). [DOI] | |
| 2019 | Meng, J; Chen, W; Wang, J (2019) 'Interventions in the B-type natriuretic peptide signalling pathway as a means of controlling chronic itch'. British Journal of Pharmacology, 177 (5). [DOI] | |
| 2018 | Meng, J.; Moriyama, M.; Feld, M.; Buddenkotte, J.; Buhl, T.; Szöllösi, A.; Zhang, J.; Miller, P.; Ghetti, A.; Fischer, M.; Reeh, P.W.; Shan, C.; Wang, J.; Steinhoff, M. (2018) 'New mechanism underlying IL-31–induced atopic dermatitis'. Journal of Allergy and Clinical Immunology, 141 . [Link] [DOI] | |
| 2017 | Nugent, M; Yusef, YR; Meng, J; Wang, J; Dolly, JO (2017) 'A SNAP-25 cleaving chimera of botulinum neurotoxin /A and /E prevents TNFα-induced elevation of the activities of native TRP channels on early postnatal rat dorsal root ganglion neurons'. Neuropharmacology, 138 . [DOI] | |
| 2017 | Wang, J.; Casals-Diaz, L.; Zurawski, T.; Meng, J.; Moriarty, O.; Nealon, J.; Edupuganti, O.P.; Dolly, O. (2017) 'A novel therapeutic with two SNAP-25 inactivating proteases shows long-lasting anti-hyperalgesic activity in a rat model of neuropathic pain'. Neuropharmacology, 118 . [Link] [DOI] | |
| 2017 | Nugent, M; Wang, J; Lawrence, G; Zurawski, T; Geoghegan, JA; Dolly, JO (2017) 'Conjugate of an IgG Binding Domain with Botulinum Neurotoxin A Lacking the Acceptor Moiety Targets Its SNARE Protease into TrkA-Expressing Cells When Coupled to Anti-TrkA IgG or Fc-βNGF'. Bioconjugate Chemistry, 28 (6). [DOI] | |
| 2016 | Wang, J; Meng, J; Nugent, M; Tang, M; Dolly, JO (2016) 'Neuronal entry and high neurotoxicity of botulinum neurotoxin A require its N-terminal binding sub-domain'. Scientific Reports, 7 . [DOI] | |
| 2016 | Meng, J.; Wang, J.; Steinhoff, M.; Dolly, J.O. (2016) 'TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion'. Scientific Reports, 6 . [Link] [DOI] | |
| 2015 | Dolly, J. Oliver; Wang, Jiafu (2015) 'Engineering of botulinum neurotoxins as novel therapeutic tools'. COMPREHENSIVE SOURCEBOOK OF BACTERIAL PROTEIN TOXINS, 4TH EDITION, . [DOI] | |
| 2014 | Lawrence, GW; Wang, J; Brin, MF; Aoki, KR; Wheeler, L; Dolly, JO (2014) 'Fusion of Golgi-derived vesicles mediated by SNAP-25 is essential for sympathetic neuron outgrowth but relatively insensitive to botulinum neurotoxins in vitro'. The FEBS journal, 281 (14). [DOI] | |
| 2014 | Ma, H; Meng, J; Wang, J; Hearty, S; Dolly, JO; O'Kennedy, R (2014) 'Targeted delivery of a SNARE protease to sensory neurons using a single chain antibody (scFv) against the extracellular domain of P2X(3) inhibits the release of a pain mediator'. The Biochemical journal, 462 (2). [DOI] | |
| 2014 | Boddul, S.V.; Meng, J.; Dolly, J.O.; Wang, J. (2014) 'SNAP-23 and VAMP-3 contribute to the release of IL-6 and TNFα from a human synovial sarcoma cell line'. FEBS Journal, 281 . [Link] [DOI] | |
| 2013 | Meng, J; Dolly, JO; Wang, J (2013) 'Selective cleavage of SNAREs in sensory neurons unveils protein complexes mediating peptide exocytosis triggered by different stimuli'. Molecular Neurobiology, 50 (2). [DOI] | |
| 2013 | Lawrence, G.W.; Ovsepian, S.V.; Wang, J.; Aoki, K.R.; Dolly, J.O. (2013) 'Therapeutic effectiveness of botulinum neurotoxin A: Potent blockade of autonomic transmission by targeted cleavage of only the pertinent SNAP-25'. Neuropharmacology, 70 . [Link] [DOI] | |
| 2013 | Meng, J; Wang, J; Lawrence, GW; Dolly, JO (2013) 'Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons'. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27 (8). [DOI] | |
| 2013 | Al-Sabi, A; Kaza, SK; Dolly, JO; Wang, J (2013) 'Pharmacological characteristics of Kv1.1- and Kv1.2-containing channels are influenced by the stoichiometry and positioning of their α subunits'. The Biochemical journal, 454 (1). [DOI] | |
| 2012 | Lawrence, G.W.; Ovsepian, S.V.; Wang, J.; Aoki, K.R.; Dolly, J.O. (2012) 'Extravesicular intraneuronal migration of internalized botulinum neurotoxins without detectable inhibition of distal neurotransmission'. Biochemical Journal, 441 . [Link] [DOI] | |
| 2012 | Edupuganti, OP; Ovsepian, SV; Wang, J; Zurawski, TH; Schmidt, JJ; Smith, L; Lawrence, GW; Dolly, JO (2012) 'Targeted delivery into motor nerve terminals of inhibitors for SNARE-cleaving proteases via liposomes coupled to an atoxic botulinum neurotoxin'. The FEBS journal, 279 (14). [DOI] | |
| 2012 | Wang, J; Zurawski, TH; Bodeker, MO; Meng, J; Boddul, S; Aoki, KR; Dolly, JO (2012) 'Longer-acting and highly potent chimaeric inhibitors of excessive exocytosis created with domains from botulinum neurotoxin A and B'. The Biochemical journal, 444 (1). [DOI] | |
| 2012 | Wang, J; Zurawski, TH; Meng, J; Lawrence, GW; Aoki, KR; Wheeler, L; Dolly, JO (2012) 'Novel chimeras of botulinum and tetanus neurotoxins yield insights into their distinct sites of neuroparalysis'. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26 (12). [DOI] | |
| 2011 | Al-Sabi, A; Kaza, S; Le Berre, M; O'Hara, L; Bodeker, M; Wang, J; Dolly, JO (2011) 'Position-dependent attenuation by Kv1.6 of N-type inactivation of Kv1.4-containing channels'. The Biochemical journal, 438 (2). [DOI] | |
| 2011 | Dolly, JO; Wang, J; Zurawski, TH; Meng, J (2011) 'Novel therapeutics based on recombinant botulinum neurotoxins to normalize the release of transmitters and pain mediators'. The FEBS journal, 278 (23). [DOI] | |
| 2010 | Wang, J; Zurawski, TH; Meng, J; Lawrence, G; Olango, WM; Finn, DP; Wheeler, L; Dolly, JO (2010) 'A dileucine in the protease of botulinum toxin A underlies its long-lived neuroparalysis: transfer of longevity to a novel potential therapeutic'. The Journal of biological chemistry, 286 (8). [DOI] | |
| 2010 | Al-Sabi, A; Shamotienko, O; Dhochartaigh, SN; Muniyappa, N; Le Berre, M; Shaban, H; Wang, J; Sack, JT; Dolly, JO (2010) 'Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium'. The Journal of general physiology, 136 (3). [DOI] | |
| 2009 | Meng, J.; Ovsepian, S.V.; Wang, J.; Pickering, M.; Sasse, A.; Aoki, K.R.; Lawrence, G.W.; Dolly, J.O. (2009) 'Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential'. Journal of Neuroscience, 29 . [Link] [DOI] | |
| 2008 | Wang, J; Meng, J; Lawrence, GW; Zurawski, TH; Sasse, A; Bodeker, MO; Gilmore, MA; Fernández-Salas, E; Francis, J; Steward, LE; Aoki, KR; Dolly, JO (2008) 'Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics'. The Journal of biological chemistry, 283 (25). [DOI] | |
| 2007 | Meng, J.; Wang, J.; Lawrence, G.; Dolly, J.O. (2007) 'Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential'. Journal of Cell Science, 120 . [Link] [DOI] | |
| 2006 | Lawrence, G; Wang, J; Chion, CK; Aoki, KR; Dolly, JO (2006) 'Two protein trafficking processes at motor nerve endings unveiled by botulinum neurotoxin E'. The Journal of pharmacology and experimental therapeutics, 320 (1). [DOI] |
Other Publication
| Year | Publication | |
|---|---|---|
| 2022 | Yang, H.; Chen, W.; Zhu, R.; Wang, J.; Meng, J. (2022) Critical Players and Therapeutic Targets in Chronic Itch. [Link] [DOI] | |
| 2015 | Meng, J.; Wang, J. (2015) Role of SNARE proteins in tumourigenesis and their potential as targets for novel anti-cancer therapeutics. [Link] [DOI] | |
| 2015 | Meng, J.; Wang, J.; Steinhoff, M.; Dolly, O. (2015) TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/Syntaxin1/SNAP-25 mediated fusion. | |
| 2022 | Wang, Jiafu; Wang, Wanzhi; Kong, Miaomiao; Dou, Yu; Xue, Shanghai; Liu, Yang; Zhang, Yinghao; Chen, Weiwei; Li, Yanqing; Dai, Xiaolong; Meng, Jianghui (2022) Selective Expression of the Protease of Botulinum Neurotoxin Type A1 in Nociceptive Neurons Persistently Blocks Neurotransmission. | |
| 2021 | Wang, Jiafu; Tang, Minhong; Meng, Jianghui (2021) NOVEL SECRETION INHIBITORS OF PAIN-RELATED MEDIATORS WITH POTENTIAL FOR RELIEVING CHRONIC PAIN. | |
| 2021 | Meng, J; Li, Y; Fischer, MJM; Steinhoff, M; Chen, W; Wang, J (2021) Th2 Modulation of Transient Receptor Potential Channels: An Unmet Therapeutic Intervention for Atopic Dermatitis. [Link] [DOI] |
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