Patricia Johnson
Dr
Dr
Johnson’s career spans several years of researching in the area of Biomedical
Science. Her PhD project explored the underlying immune mechanisms involved in
the development of immune pathologies associated with primary and secondary
vasculitis (published manuscripts: Clin Exp Immunol 1997; 108:234-242. Clin Exp
Immunol 1997; 111:98-105). Owing to her contributions to this area, she was
commissioned to carry out a review of associated patent literature and
intellectual property (ExpOpin in Therapeutic Patents. 2002 12 (10) 1517-1525.)
and to present an educational article for Nature Encyclopaedia of Life
Sciences. (Nature Publishing Group. 2003).
Dr
Johnson continued to work post-doctorally in the area of Biomedical Science
contributing to an EU project with Professor Kingston Mills, (TCD, formerly
NUIM) on DNA vaccines against influenza virus. (J of Gen Virol 2000,
81;1737-1745). These studies occasioned further investigations on the
immunomodulation associated with mixed infections (J Infect Dis 2000 182(4):1286-9).
Success with DNA vaccine studies led to further funding from Glaxo Smithkline,
to investigate DNA vaccine constructs encoding surface glycoproteins from HIV
(J of Clin Virol. 2000 18:303 and Vaccine 2005 Jan 4;23(7):963-74).
On
completion her postdoctoral study she established her own research team, the
Viral Immunology Group (VIG), at the Institute of Immunology, NUIM, under the
PPRTLI programme. Her research team identified a novel immune-modulation
mechanism associated with influenza virus (J. Gen Virol 2005, 86, 1885-90). She
then secured funding from the EU to develop a novel vaccine construct against
childhood respiratory diseases, leading to published studies;- J. Leuk Biol
2007 Apr;81(4):952-6; J Virol. 2008 82(9299-302). In May 2005 Dr Johnson moved
to a tenured position in DCU and continued to grow her research laboratory. She
has since secured funding from the Wellcome Trust, HRB, IRCSET, EI and MUH with
several published, in submission or submission-ready manuscripts from these
projects (Drug Discovery Today-DM 2010; 6(4): 107-112; Br J Anaesth. 2014 113
Suppl 1:i56-62, BJA ms no#-2013-01344: In submission JI-CE 13-03246: Submission
ready JCI, JCV).
Dr
Johnson has also presented her findings at many national and international
meetings and has participated in numerous research-support roles; She has acted
as expert reviewer for the EU 5th
Framework Control of Infectious Disease Programme and has attended and
reviewed two mid-term EU 5th framework
progress meetings at Epalinges University Campus Lausanne, and the Istituto
Superiore di Sanità, Rome. She have also organized and hosted and 5th &
6th EU framework meetings and served as
coordinator for the joint ISI/UIG Annual Meeting at NUIM and ISI annual meeting
held in DCU.
Dr
Johnson has successfully supervised three PhD students to completion directly
under her supervision. All of her students have presented their findings at
international meetings and have published their findings in peer reviewed
medium to high impact journals in the field. Dr Johnson has also acted as
research supervisor to a successful MD candidate and is currently supervising
an additional PhD candidate and postgraduate Erasmus Training Programme
student. In addition, she has supervised numerous undergraduate and short
research projects students (> 25) in both DCU and NUIM.
Peer Reviewed Journal
Year | Publication | |
---|---|---|
2021 | Maguire, PT;Loughran, ST;Harvey, R;Johnson, PA (2021) 'A TLR5 mono-agonist restores inhibited immune responses to Streptococcus pneumoniae during influenza virus infection in human monocytes'. PLoS ONE, 16 (10). [DOI] | |
2020 | McQuaid SL;Loughran ST;Power PA;Maguire P;Szczygiel A;Johnson PA; (2020) 'Low-dose IL-2 induces CD56bright NK regulation of T cells via NKp44 and NKp46'. Clinical and Experimental Immunology, 200 (3). [DOI] | |
2019 | O'Reilly D.;Johnson P.;Buchanan P. (2019) 'Hypoxia induced cancer stem cell enrichment promotes resistance to androgen deprivation therapy in prostate cancer'. Steroids, 152 . [DOI] | |
2018 | Loughran, ST;Power, PA;Maguire, PT;McQuaid, SL;Buchanan, PJ;Jonsdottir, I;Newman, RW;Harvey, R;Johnson, PA (2018) 'Influenza infection directly alters innate IL-23 and IL-12p70 and subsequent IL-17A and IFN-gamma responses to pneumococcus in vitro in human monocytes'. PLoS ONE, 13 . [DOI] | |
2018 | McQuaid, S;Loughran, S;Power, P;Maguire, P;Walls, D;Cusi, MG;Orvell, C;Johnson, P (2018) 'Haemagglutinin-neuraminidase from HPIV3 mediates human NK regulation of T cell proliferation via NKp44 and NKp46'. Journal of General Virology, 99 :763-767. [DOI] | |
2014 | Buckley A, McQuaid S, Johnson PA, Buggy DJ, (2014) 'Serum from women undergoing breast cancer surgery, randomized to distinct anaesthetic techniques, exerts different effects on healthy Natural Killer cell anti-tumour activity: A Pilot Study'. British Journal of Anaesthesia, 113 (Suppl 1):56-62. | |
2014 | Buckley A.;McQuaid S.;Johnson P.;Buggy D. (2014) 'Effect of anaesthetic technique on the natural killer cell anti-tumour activity of serum from women undergoing breast cancer surgery: A pilot study'. British Journal of Anaesthesia, 113 (SUPPL. 1):i56-i62. [DOI] | |
2010 | Power P, Loughran S and Johnson PA. (2010) 'Modelling the Effect of Infection on Asthma. Drug Discovery Today-Disease Models 2010; 6 (4): 107-112'. 6 :107-112. | |
2009 | Madsen D, Cantwell ER, O’Brien T, Johnson PA and Mahon BP (2009) 'AAV-2 induces cell mediated immune responses directed against multiple epitopes of the capsid protein VP1'. Journal of General Virology, 90 :2622-2633. | |
2008 | Noone, C.M., Lewis, E.A., Loetscher, M., Newman, R.W., Johnson, P.A. (2008) 'Natural killer cells regulate T cell proliferation during Human Parainfluenza Virus infection'. Journal of Virology, 82 . | |
2007 | Noone CM, Lewis EA, Newman RW and Johnson PA (2007) 'Artificially generated dendritic cells misdirect antiviral immune responses'. JOURNAL OF LEUKOCYTE BIOLOGY, 8 :952-956. | |
2007 | Noone, C;Manahan, E;Newman, R;Johnson, P (2007) 'Artificially generated dendritic cells misdirect antiviral immune responses'. Journal Of Leukocyte Biology, 81 :952-956. [DOI] | |
2005 | Daly L M,. Johnson PA. Nicolson C, Robertson J and Kingston H.G. Mills (2005) 'Innate IL-10 rpromotes the induction of type 2 T cell responses with plasmid DNA coding for HIVgp120'. Vaccine, 23 :967-974. | |
2005 | Noone C M, Frawely AB, Doyle MF, Mahon BP, Mills KH and. Johnson PA (2005) 'Novel mechanism of immunosuppression by influenza virus haemagglutinin: selective suppression of IL-12p35 transcription'. Journal of General Virology, 86 :1885-1890. | |
2002 | Johnson P.A. (2002) 'Molecules that target key events in macrophage migration'. EXPERT OPINION IN THERAPEUTIC PATENTS, 12 :1517-1525. | |
2000 | Daly LM, Johnson PA, Mills KHG (2000) 'DNA vaccines strategies for selective induction of Th1 or Th2 cells. Journal of Clinical Virology'. Journal of Clinical Virology, 18 :303-303. | |
2000 | Johnson PA, Conway M, Daly L, Nicolson C, Robertson J, Mills KHG (2000) 'Plasmid DNA coding for influenza virus haemagglutinin induces Th1 cells and protects against respiratory infection despite its limited ability to generate antibody'. Journal of General Virology, 81 :1737-1745. | |
2000 | McGuirk P, Johnson PA, Ryan EJ and Mills KHG (2000) 'Filamentous haemagglutin and pertussis toxin from Bordetella pertussis modulate immune responses to unrelated antigens'. JOURNAL OF INFECTIOUS DISEASE, 182 :1286-1289. | |
1999 | Johnson PA, Conway M, Cox-Brokstad R, Haaheim L, Daly J, Robertson J, Mills KHG. (1999) 'Selective Induction of Th1 cells with Plasmid DNA coding for influenza virus haemaggluttin. In Proceedings of European Biotechnology meeting on Vaccines'. . | |
1998 | Johnson PA, Conway M and Mills KHG (1998) 'DNA vaccines: Mechanism of antigen presentation leading to selective induction of Th1 cells'. Immunology, 95 . | |
1997 | Johnson PA, Alexander HD, McMillan SA, Maxwell AP (1997) 'Up-regulation of the endothelial cell adhesion molecule intercellular adhesion molecule-1 (ICAM-1) by autoantibodies in autoimmune vasculitis'. 108 :234-242. | |
1997 | Johnson PA, Alexander HD, McMillan SA, Maxwell AP (1997) 'The up-regulation of the granulocyte adhesion molecule Mac-1 in Autoimmune Vasculitis'. 107 :513-519. |
Review Articles
Year | Publication | |
---|---|---|
2009 | Power P.;Loughran S.;Johnson P. (2009) Modelling the effect of infection on asthma. REV [DOI] |
Certain data included herein are derived from the © Web of Science (2022) of Clarivate. All rights reserved.
Honors and Awards
Research Interests
Viral Immunology particularly immune responses associated with respiratory viruses such as Human Parainfluenza Virus (HPIV), Influenza, Respiratory Syncytial Virus (RSV) and Rhino Virus (RV).
Viral subversion of immune responses and the induction of immune regulation.
Role of anti-viral immune responses in the development of associated secondary conditions such as bacterial superinfections and asthma.
Development of human cellular model systems to predict immune responses to viruses, viral vaccines and other therapeutic interventions.