Researcher Details |

Jianghui Meng

Dr. Jianghui Meng is a PI in Molecular Neuroscience and Neurotherapeutics in the National Institute of Cellular Biotechnology, is funded by SFI, Sanofi, and LEO foundation on the translational neuroscience and dermatology. Dr. Meng’s current research interests are focused on defining the itch and pain signaling pathways, elucidating neuroimmune modulation of chronic itch and pain, and developing novel analgesics and antipruritics. These therapeutics have advantages being effective and cost-efficient, with abilities to change patients’ life in a meaningful way. Dr. Meng has established several novel concepts for itch and pain management and identified novel therapeutic interventions, which formed the new basis for the accomplishment of transformational “mechanism-based” high-quality treatments.

Peer Reviewed Journal

	Year	Publication
	2024	Li, Y.; Chen, W.; Zhu, X.; Mei, H.; Steinhoff, M.; Buddenkotte, J.; Wang, J.; Zhang, W.; Li, Z.; Dai, X.; Shan, C.; Wang, J.; Meng, J. (2024) 'Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27–Driven Itch Pathway'. Journal of Investigative Dermatology, . [Link] [DOI]
	2023	Wang, R; Dai, X; Chen, W; Wang, J; Wang, H; Yan, X; Zhang, W; Fan, Q; Li, L; Wang, J; Meng, J (2023) 'Matrix Metalloproteinase 9 Plays a Crucial Role in Inflammation and Itch in Allergic Contact Dermatitis by Regulating Toll-Like Receptor 2/1 Signaling'. The Journal of investigative dermatology, . [DOI]
	2023	Dai, X.; Li, L.; Yan, X.; Fan, Q.; Wang, R.; Zhang, W.; Chen, W.; Liu, Y.; Meng, J.; Wang, J. (2023) 'Myeloid Vamp3 deletion attenuates CFA-induced inflammation and pain in mice via ameliorating macrophage infiltration and inflammatory cytokine production'. Frontiers in Immunology, 14 . [Link] [DOI]
		Meng J; Steinhoff M; 'Molecular mechanisms of pruritus'. Current Research In Translational Medicine, 64 (4). [DOI]
	2023	Yang, H; Zhu, R; Zhang, W; Chen, W; Yan, X; Shan, C; Xue, S; Wang, R; Dai, X; Wang, J; Larkin, C; Wang, J; Meng, J (2023) 'Urotensin II/GPR14 Pathway Regulates Chronic Itch in Mice'. The Journal of investigative dermatology, 143 (12). [DOI]
	2022	Steinhoff, M.; Ahmad, F.; Pandey, A.; Datsi, A.; AlHammadi, A.; Al-Khawaga, S.; Al-Malki, A.; Meng, J.; Alam, M.; Buddenkotte, J. (2022) 'Neuroimmune communication regulating pruritus in atopic dermatitis'. Journal of Allergy and Clinical Immunology, 149 . [Link] [DOI]
	2022	Zhu, R; Yang, H; Xue, S; Fan, Q; Zhang, W; Wang, R; Chen, W; Li, L; Wang, J; Meng, J (2022) 'Intervening GSK3 Signaling Attenuates Cutaneous Inflammation and Itch in Mice: Implication for Future Therapeutic Development'. The Journal of investigative dermatology, 143 (2). [DOI]
	2022	Chen, W.; Li, Y.; Steinhoff, M.; Zhang, W.; Buddenkotte, J.; Buhl, T.; Zhu, R.; Yan, X.; Lu, Z.; Xiao, S.; Wang, J.; Meng, J. (2022) 'The PLAUR signaling promotes chronic pruritus'. FASEB Journal, 36 . [Link] [DOI]
	2023	Zhang, W.; Chen, W.; Shan, C.; Wang, R.; Li, L.; Wang, J.; Meng, J. (2023) 'IL-13 Activates Cutaneous Schwann Cells to Promote CCL7-Dependent Pruritic Signaling in Atopic Dermatitis'. Journal of Investigative Dermatology, 143 . [Link] [DOI]
	2022	Lu, Z.; Xiao, S.; Chen, W.; Zhu, R.; Yang, H.; Steinhoff, M.; Li, Y.; Cheng, W.; Yan, X.; Li, L.; Xue, S.; Larkin, C.; Zhang, W.; Fan, Q.; Wang, R.; Wang, J.; Meng, J. (2022) 'IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis'. FASEB Journal, 36 . [Link] [DOI]
	2021	Xiao, S.; Lu, Z.; Steinhoff, M.; Li, Y.; Buhl, T.; Fischer, M.; Chen, W.; Cheng, W.; Zhu, R.; Yan, X.; Yang, H.; Liu, Y.; Dou, Y.; Wang, W.; Wang, J.; Meng, J. (2021) 'Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis'. Brain, Behavior, and Immunity, 98 . [Link] [DOI]
	2021	Wang, W.; Kong, M.; Dou, Y.; Xue, S.; Liu, Y.; Zhang, Y.; Chen, W.; Li, Y.; Dai, X.; Meng, J.; Wang, J. (2021) 'Selective expression of a snare-cleaving protease in peripheral sensory neurons attenuates pain-related gene transcription and neuropeptide release'. International Journal of Molecular Sciences, 22 . [Link] [DOI]
	2021	Larkin, C.; Chen, W.; Szabó, I.L.; Shan, C.; Dajnoki, Z.; Szegedi, A.; Buhl, T.; Fan, Y.; O'Neill, S.; Walls, D.; Cheng, W.; Xiao, S.; Wang, J.; Meng, J. (2021) 'Novel insights into the TRPV3-mediated itch in atopic dermatitis'. Journal of Allergy and Clinical Immunology, 147 . [Link] [DOI]
	2020	Tang, M.; Meng, J.; Wang, J. (2020) 'New engineered-botulinum toxins inhibit the release of pain-related mediators'. International Journal of Molecular Sciences, 21 . [Link] [DOI]
	2019	Meng, J; Chen, W; Wang, J (2019) 'Interventions in the B-type natriuretic peptide signalling pathway as a means of controlling chronic itch'. British Journal of Pharmacology, 177 (5). [DOI]
	2019	Szöllősi, A.G.; McDonald, I.; Szabó, I.L.; Meng, J.; van den Bogaard, E.; Steinhoff, M. (2019) 'TLR3 in Chronic Human Itch: A Keratinocyte-Associated Mechanism of Peripheral Itch Sensitization'. Journal of Investigative Dermatology, 139 . [Link] [DOI]
	2019	Meng, J.; Wang, J.; Buddenkotte, J.; Buhl, T.; Steinhoff, M. (2019) 'Role of SNAREs in Atopic Dermatitis–Related Cytokine Secretion and Skin-Nerve Communication'. Journal of Investigative Dermatology, 139 . [Link] [DOI]
	2018	Meng, J.; Moriyama, M.; Feld, M.; Buddenkotte, J.; Buhl, T.; Szöllösi, A.; Zhang, J.; Miller, P.; Ghetti, A.; Fischer, M.; Reeh, P.W.; Shan, C.; Wang, J.; Steinhoff, M. (2018) 'New mechanism underlying IL-31–induced atopic dermatitis'. Journal of Allergy and Clinical Immunology, 141 . [Link] [DOI]
	2018	Nugent, M.; Yusef, Y.R.; Meng, J.; Wang, J.; Dolly, J.O. (2018) 'A SNAP-25 cleaving chimera of botulinum neurotoxin /A and /E prevents TNFα−induced elevation of the activities of native TRP channels on early postnatal rat dorsal root ganglion neurons'. Neuropharmacology, 138 . [Link] [DOI]
	2017	Wang, J.; Casals-Diaz, L.; Zurawski, T.; Meng, J.; Moriarty, O.; Nealon, J.; Edupuganti, O.P.; Dolly, O. (2017) 'A novel therapeutic with two SNAP-25 inactivating proteases shows long-lasting anti-hyperalgesic activity in a rat model of neuropathic pain'. Neuropharmacology, 118 . [Link] [DOI]
	2016	Wang, J; Meng, J; Nugent, M; Tang, M; Dolly, JO (2016) 'Neuronal entry and high neurotoxicity of botulinum neurotoxin A require its N-terminal binding sub-domain'. Scientific Reports, 7 . [DOI]
	2016	Meng, Jianghui; Wang, Jiafu; Steinhoff, Martin; Dolly, James Oliver (2016) 'TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion'. Scientific Reports, 6 . [DOI]
	2016	Meng, J.; Wang, J.; Steinhoff, M.; Dolly, J.O. (2016) 'TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion'. Scientific Reports, 6 . [Link] [DOI]
	2014	Ma, H.; Meng, J.; Wang, J.; Hearty, S.; Dolly, J.O.; O'Kennedy, R. (2014) 'Targeted delivery of a SNARE protease to sensory neurons using a single chain antibody (scFv) against the extracellular domain of P2X3 inhibits the release of a pain mediator'. Biochemical Journal, 462 . [Link] [DOI]
	2013	Meng, J; Dolly, JO; Wang, J (2013) 'Selective cleavage of SNAREs in sensory neurons unveils protein complexes mediating peptide exocytosis triggered by different stimuli'. Molecular Neurobiology, 50 (2). [DOI]
	2014	Boddul, S.V.; Meng, J.; Dolly, J.O.; Wang, J. (2014) 'SNAP-23 and VAMP-3 contribute to the release of IL-6 and TNFα from a human synovial sarcoma cell line'. FEBS Journal, 281 . [Link] [DOI]
	2013	Meng, J; Wang, J; Lawrence, GW; Dolly, JO (2013) 'Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons'. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27 (8). [DOI]
	2012	Wang, J; Zurawski, TH; Bodeker, MO; Meng, J; Boddul, S; Aoki, KR; Dolly, JO (2012) 'Longer-acting and highly potent chimaeric inhibitors of excessive exocytosis created with domains from botulinum neurotoxin A and B'. The Biochemical journal, 444 (1). [DOI]
	2012	Wang, J; Zurawski, TH; Meng, J; Lawrence, GW; Aoki, KR; Wheeler, L; Dolly, JO (2012) 'Novel chimeras of botulinum and tetanus neurotoxins yield insights into their distinct sites of neuroparalysis'. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26 (12). [DOI]
	2011	Wang, J.; Zurawski, T.H.; Meng, J.; Lawrence, G.; Olango, W.M.; Finn, D.P.; Wheeler, L.; Dolly, J.O. (2011) 'A dileucine in the protease of botulinum toxin A underlies its long-lived neuroparalysis: Transfer of longevity to a novel potential therapeutic'. Journal of Biological Chemistry, 286 . [Link] [DOI]
	2009	Meng, J.; Ovsepian, S.V.; Wang, J.; Pickering, M.; Sasse, A.; Aoki, K.R.; Lawrence, G.W.; Dolly, J.O. (2009) 'Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential'. Journal of Neuroscience, 29 . [Link] [DOI]
	2008	Wang, J.; Meng, J.; Lawrence, G.W.; Zurawski, T.H.; Sasse, A.; Bodeker, M.O.; Gilmore, M.A.; Fernández-Salas, E.; Francis, J.; Steward, L.E.; Aoki, K.R.; Dolly, J.O. (2008) 'Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics'. Journal of Biological Chemistry, 283 . [Link] [DOI]
	2008	Cheong, SC; Wang, Y; Meng, JH; Hill, R; Sweeney, K; Kirn, D; Lemoine, NR; Hallden, G (2008) 'E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models'. Cancer Gene Therapy, 15 :40-50. [DOI]
	2007	Meng, J.; Wang, J.; Lawrence, G.; Dolly, J.O. (2007) 'Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential'. Journal of Cell Science, 120 . [Link] [DOI]
	2009	Dolly, JO; Lawrence, GW; Meng, J; Wang, J; Ovsepian, SV (2009) 'Neuro-exocytosis: botulinum toxins as inhibitory probes and versatile therapeutics'. Current Opinion in Pharmacology, 9 (3). [DOI]
	2022	Xue, S.; Zhu, R.; Chen, W.; Yang, H.; Wang, J.; Meng, J. (2022) 'Inhibiting Keratinocyte-Derived Signal Transducer and Activator of Transcription 6 Improved Atopic Dermatitis in Mice'. Journal of Investigative Dermatology, 142 . [Link] [DOI]

Book Chapter

	Year	Publication
	2009	Dolly, J.O.; Meng, J.; Wang, J.; Lawrence, G.W.; Bodeker, M.; Zurawski, T.H.; Sasse, A. (2009) 'Multiple steps in the blockade of exocytosis by botulinum neurotoxins' In: Botulinum Toxin: Therapeutic Clinical Practice and Science, Expert Consult - Online and Print. [Link] [DOI]
	2009	Dolly, J.O.; Meng, J.; Wang, J.; Lawrence, G.W.; Bodeker, M.; Zurawski, T.H.; Sasse, A. (2009) 'Multiple Steps in the Blockade of Exocytosis by Botulinum Neurotoxins' In: Botulinum Toxin: Therapeutic Clinical Practice and Science. [Link] [DOI]

Other Publication

	Year	Publication
	2017	Meng, J. (2017) Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer. [Link] [DOI]
	2011	Dolly, J.O.; Wang, J.; Zurawski, T.H.; Meng, J. (2011) Novel therapeutics based on recombinant botulinum neurotoxins to normalize the release of transmitters and pain mediators. [Link] [DOI]
	2022	Yang, H.; Chen, W.; Zhu, R.; Wang, J.; Meng, J. (2022) Critical Players and Therapeutic Targets in Chronic Itch. [Link] [DOI]
	2015	Meng, J.; Wang, J.; Steinhoff, M.; Dolly, O. (2015) TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/Syntaxin1/SNAP-25 mediated fusion.
	2020	Meng, J.; Chen, W.; Wang, J. (2020) Interventions in the B-type natriuretic peptide signalling pathway as a means of controlling chronic itch. [Link] [DOI]
	2022	Wang, Jiafu; Wang, Wanzhi; Kong, Miaomiao; Dou, Yu; Xue, Shanghai; Liu, Yang; Zhang, Yinghao; Chen, Weiwei; Li, Yanqing; Dai, Xiaolong; Meng, Jianghui (2022) Selective Expression of the Protease of Botulinum Neurotoxin Type A1 in Nociceptive Neurons Persistently Blocks Neurotransmission.
	2022	Meng, Jianghui; Wang, Jiafu; Xiao, Song; Chen, Weiwei; Zhu, Renkai; Yang, Hua; Li, Yanqing; Cheng, Wenke; Yan, Xinrong; Li, Lianlian; Xue, Shanghai; Larkin, Ciara; Zhang, Wenhao; Fan, Qianqian; Wang, Ruizhen; Joy, Febu; Buddenkotte, Jorg; Steinhoff, Martin (2022) INTERLEUKIN-20 PROMOTES NEURO-INFLAMMATION AND PRURITUS IN ATOPIC DERMATITIS.
	2021	Meng, J.; Li, Y.; Fischer, M.J.M.; Steinhoff, M.; Chen, W.; Wang, J. (2021) Th2 Modulation of Transient Receptor Potential Channels: An Unmet Therapeutic Intervention for Atopic Dermatitis. [Link] [DOI]
	2021	Meng, Jianghui; Wang, Jiafu; Buddenkotte, Joerg; Buhl, Timo; Steinhoff, Martin (2021) ROLE OF SNARES IN ATOPIC DERMATITIS-RELATED CYTOKINE SECRETION AND SKINNERVE COMMUNICATION.
	2021	Wang, Jiafu; Tang, Minhong; Meng, Jianghui (2021) NOVEL SECRETION INHIBITORS OF PAIN-RELATED MEDIATORS WITH POTENTIAL FOR RELIEVING CHRONIC PAIN.
	2018	Meng, J. M.; Moriyama, M. M.; Feld, M. F.; Buddenkotte, J. B.; Buhl, T. B.; Szollosi, A. S.; Zhang, J. Z.; Miller, P. M.; Ghetti, A. G.; Fischer, M. F.; Reeh, P. R.; Shan, C. S.; Wang, J. W.; Steinhoff, M. S. (2018) Role of brain-derived natriuretic peptide in atopic dermatitis.

Review Articles

	Year	Publication
	2015	Meng, Jianghui; Wang, Jiafu (2015) Role of SNARE proteins in tumourigenesis and their potential as targets for novel anti-cancer therapeutics. REV [DOI]

Research Projects

Title	Role	Start date	End date
Delineating Chronic Itch Mechanism and Developing Targeted Therapeutics	DCU PI	01/07/2024	30/06/2028
Developing Innovative Antipruritic Drug Targeting Chronic Itch	DCU PI	01/09/2022	31/08/2025
Molecular Mechanism for SNAREs in euro-epidermal communication in Atopic Dermatitis and development of their targeted therapeutics	DCU PI	01/10/2020	01/09/2021
Unravelling the role of SNARE proteins in pruritus(itch) and developing novel SNARE-targetingbiotherapeutics for treating chronic itch	DCU PI	01/11/2016	31/10/2020