Assistant Professor Achilleas Floudas completed his PhD in Immunology at Newcastle University, UK in 2014 following from his undergraduate studies in Molecular Biology at the University of Crete, Greece. In 2015 he was awarded an Irish Research Council Postdoctoral Fellowship to continue his research in Trinity College Dublin and joined the molecular Rheumatology Department in 2017. In 2020 he is awarded the CARD Research Fellow Innovation Award and in 2022 the Health Research Board Emerging Investigator Award and the EULAR abstract award. His research focuses on T cell and synovial fibroblast interactions in Rheumatoid and Psoriatic Arthritis, utilising advanced flow cytometric analysis, in vitro assays with 3D culture systems and bioinformatic analysis of RNAseq data in order to identify opportunities for more targeted therapeutic intervention.
Peer Reviewed Journal
| Year | Publication | |
|---|---|---|
| 2022 | Hunter, JE; Campbell, AE; Butterworth, JA; Sellier, H; Hannaway, NL; Luli, S; Floudas, A; Kenneth, NS; Moore, AJ; Brownridge, PJ; Thomas, HD; Coxhead, J; Taylor, L; Leary, P; Hasoon, MSR; Knight, AM; Garrett, MD; Collins, I; Eyers, CE; Perkins, ND (2022) 'Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance'. The Biochemical journal, 479 (19). [DOI] | |
| 2022 | Fearon, U; Hanlon, MM; Floudas, A; Veale, DJ (2022) 'Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications'. Nature reviews. Rheumatology, 18 (7). [DOI] | |
| 2021 | Marzaioli, V; Canavan, M; Floudas, A; Flynn, K; Mullan, R; Veale, DJ; Fearon, U (2021) 'CD209/CD14+ Dendritic Cells Characterization in Rheumatoid and Psoriatic Arthritis Patients: Activation, Synovial Infiltration, and Therapeutic Targeting'. Frontiers in Immunology, 12 . [DOI] | |
| 2021 | Floudas, A; Neto, N; Orr, C; Canavan, M; Gallagher, P; Hurson, C; Monaghan, MG; Nagpar, S; Mullan, RH; Veale, DJ; Fearon, U (2021) 'Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of rheumatoid arthritis'. Annals Of The Rheumatic Diseases, 81 (2). [DOI] | |
| 2021 | Floudas, A; Smith, CM; Tynan, O; Neto, N; Krishna, V; Wade, SM; Hanlon, M; Cunningham, C; Marzaioli, V; Canavan, M; Fletcher, JM; Mullan, RH; Cole, S; Hao, LY; Monaghan, MG; Nagpal, S; Veale, DJ; Fearon, U (2021) 'Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis'. Annals Of The Rheumatic Diseases, . [DOI] | |
| 2021 | Floudas, A; Gorman, A; Neto, N; Monaghan, MG; Elliott, Z; Fearon, U; Marzaioli, V (2021) 'Inside the Joint of Inflammatory Arthritis Patients: Handling and Processing of Synovial Tissue Biopsies for High Throughput Analysis'. Frontiers in medicine, 9 . [DOI] | |
| 2021 | Floudas, A; Canavan, M; McGarry, T; Mullan, R; Nagpal, S; Veale, DJ; Fearon, U (2021) 'ACPA Status Correlates with Differential Immune Profile in Patients with Rheumatoid Arthritis'. Cells, 10 (3). [DOI] | |
| 2020 | Cunningham, CC; Wade, S; Floudas, A; Orr, C; McGarry, T; Wade, S; Cregan, S; Fearon, U; Veale, DJ (2020) 'Serum miRNA Signature in Rheumatoid Arthritis and At-Risk Individuals'. Frontiers in Immunology, 12 . [DOI] | |
| 2020 | Marzaioli, V; Canavan, M; Floudas, A; Wade, SC; Low, C; Veale, DJ; Fearon, U (2020) 'Monocyte-Derived Dendritic Cell Differentiation in Inflammatory Arthritis Is Regulated by the JAK/STAT Axis via NADPH Oxidase Regulation'. Frontiers in Immunology, 11 . [DOI] | |
| 2020 | Canavan, M; Floudas, A; Veale, DJ; Fearon, U (2020) 'The PD-1:PD-L1 axis in Inflammatory Arthritis'. Bmc Rheumatology, 5 (1). [DOI] | |
| 2020 | Floudas, A; Neto, N; Marzaioli, V; Murray, K; Moran, B; Monaghan, MG; Low, C; Mullan, RH; Rao, N; Krishna, V; Nagpal, S; Veale, DJ; Fearon, U (2020) 'Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint'. Jci Insight, 5 (21). [DOI] | |
| 2020 | Saunders, SP; Floudas, A; Moran, T; Byrne, CM; Rooney, MD; Fahy, CMR; Geoghegan, JA; Iwakura, Y; Fallon, PG; Schwartz, C (2020) 'Dysregulated skin barrier function in Tmem79 mutant mice promotes IL-17A-dependent spontaneous skin and lung inflammation'. Allergy, 75 (12). [DOI] | |
| 2019 | Floudas, A; Aviello, G; Schwartz, C; Jeffery, IB; O'Toole, PW; Fallon, PG (2019) 'Schistosoma mansoni Worm Infection Regulates the Intestinal Microbiota and Susceptibility to Colitis'. Infection and Immunity, 87 (8). [DOI] | |
| 2019 | Ui Mhaonaigh, A; Coughlan, AM; Dwivedi, A; Hartnett, J; Cabral, J; Moran, B; Brennan, K; Doyle, SL; Hughes, K; Lucey, R; Floudas, A; Fearon, U; McGrath, S; Cormican, S; De Bhailis, A; Molloy, EJ; Brady, G; Little, MA (2019) 'Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies'. Frontiers in Immunology, 10 . [DOI] | |
| 2019 | Foley, C; Floudas, A; Canavan, M; Biniecka, M; MacDermott, EJ; Veale, DJ; Mullan, RH; Killeen, OG; Fearon, U (2019) 'Increased T Cell Plasticity With Dysregulation of Follicular Helper T, Peripheral Helper T, and Treg Cell Responses in Children With Juvenile Idiopathic Arthritis and Down Syndrome-Associated Arthritis'. Arthritis & Rheumatology (Hoboken, N.J.), 72 (4). [DOI] | |
| 2018 | Schwartz, C; Moran, T; Saunders, SP; Kaszlikowska, A; Floudas, A; Bom, J; Nunez, G; Iwakura, Y; O'Neill, L; Irvine, AD; McKenzie, ANJ; Ogg, G; Walsh, PT; Demengeot, J; Fallon, PG (2018) 'Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β'. Allergy, 74 (10). [DOI] | |
| 2017 | Floudas, A.; Cluxton, C.D.; Fahel, J.; Khan, A.R.; Saunders, S.P.; Amu, S.; Alcami, A.; Fallon, P.G. (2017) 'Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A'. PLoS Neglected Tropical Diseases, 11 . [Link] [DOI] | |
| 2017 | Floudas, A; Saunders, SP; Moran, T; Schwartz, C; Hams, E; Fitzgerald, DC; Johnston, JA; Ogg, GS; McKenzie, AN; Walsh, PT; Fallon, PG (2017) 'IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation'. Journal of immunology (Baltimore, Md. : 1950), 199 (2). [DOI] | |
| 2016 | Floudas, A; Amu, S; Fallon, PG (2016) 'New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression'. Journal of Clinical Immunology, 36 Suppl 1 . [DOI] | |
| 2014 | Saunders, SP; Moran, T; Floudas, A; Wurlod, F; Kaszlikowska, A; Salimi, M; Quinn, EM; Oliphant, CJ; Núñez, G; McManus, R; Hams, E; Irvine, AD; McKenzie, AN; Ogg, GS; Fallon, PG (2014) 'Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity'. The Journal of allergy and clinical immunology, 137 (2). [DOI] | |
| 2014 | Khan, A.R.; Hams, E.; Floudas, A.; Sparwasser, T.; Weaver, C.T.; Fallon, P.G. (2014) 'PD-L1hi B cells are critical regulators of humoral immunity'. Nature Communications, 6 . [Link] [DOI] | |
| 2013 | Ciechomska, M; Wilson, CL; Floudas, A; Hui, W; Rowan, AD; van Eden, W; Robinson, JH; Knight, AM (2013) 'Antigen-specific B lymphocytes acquire proteoglycan aggrecan from cartilage extracellular matrix resulting in antigen presentation and CD4+ T-cell activation'. Immunology, 141 (1). [DOI] |
Certain data included herein are derived from the © Web of Science (2023) of Clarivate. All rights reserved.
Honors and Awards
Outreach Activities
Media
Research Interests
Immunology Bioinformatics and Single Cell RNAseq analysis Cell-cell interactions – translational research Immunotherapeutics
Research Projects
Teaching Interests
Immunology, Molecular Biology, Translational Research, RNAseq
Promoting a safe, inclusive environment for ideas to be exchanged. Encouraging constructive dialogue with the students and critical thinking through interactive sessions and the use of live polling app