Researcher Details |

Barry Byrne

October 2020-Present: Biological and General Safety Officer, Faculty of Science & Health, Dublin City University.

September 2021-Present: Module Coordinator (Biosafety/Project Management). Faculty of Science & Health, Dublin City University.

January 2017-September 2020: Project Manager, Fraunhofer Project Centre for Embedded Bioanalytical Sciences at Dublin City University (FPC@DCU).

July 2011 - December 2016: Integration Manager, Biomedical Diagnostics Institute.

September 2009 - June 2011: Laboratory Manager, Centre for Bioanalytical Sciences, Dublin City University.

December 2005 - August 2009: Postdoctoral Researcher. Centre for Bioanalytical Sciences and Applied Biochemistry Group, Dublin City University.

October 2004 - November 2005: Postdoctoral Researcher. Prion Research Group, University College Dublin.

October 1999 - April 2004: Ph.D. Researcher. Polyketide Engineering Group, University College Dublin.

Conference Contribution

	Year	Publication
		McGrath, R.T., McKinnon, T.A.J., Byrne, B., O'Kennedy, R., Terraube, V., McRae, E., Preston, R.J.S., Laffan, M. and O'Donnell, J.S. Haematology Association Ireland, Annual Meeting, 2009 Sialic Acid Expression on von Willebrand Factor - A Novel Critical Regulator of ADAMTS13 Proteolysis and Functional Activity .
		Byrne, B. and Caffrey, P. Society for General Microbiology (SGM) Meeting 2004 Novel polyenes produced by engineered Streptomyces nodosus strains .
		McGrath, R.T., Van den Biggelaar, M., Byrne, B., McRae, E., Rawley, O., Preston, R.J.S., O'Kennedy, R., Voorberg, J. and O'Donnell, J.S. Haematology Association Ireland, Annual Meeting, 2010 Platelet-derived von Willebrand factor demonstrates specific resistance to ADAMTS13 proteolysis .
		Reeves, E.P., Williamson, M., Byrne, B., O'Kennedy, R., O'Neill, S.J., Greally, P. and McElvaney, N.G. Annual North American Cystic Fibrosis Conference, 2009 Interleukin-8 dictates glycosaminoglycan binding and stability of interleukin-18 in cystic fibrosis .
		McGrath, R., McKinnon, T.A.J., Byrne, B., O’Kennedy, R., Laffan, M.A., McRae, E., Preston, R.J.S. and O’Donnell, J.S. 51st American Society of Haematology Meeting and Exposition, 2009 Terminal alpha-2,6-linked sialic acid expression enhances VWF proteolysis by ADAMTS13 .
		McGrath, R.T., McKinnon, T.A.J., Byrne, B., O'Kennedy, R., Terraube, V., McRae, E., Preston, R.J.S., Laffan, M. and O'Donnell, J.S. 51st American Society of Haematology Meeting and Exposition, 2009 Sialic Acid Expression on von Willebrand Factor - A Novel Critical Regulator of ADAMTS13 Proteolysis and Functional Activity .

Book Chapter

	Year	Publication
	2017	Byrne, B.;Barrett, L.M. (2017) 'Lab-on-a-Chip immunoassay systems' In: Immunoassays: Development, Applications and Future Trends. Link
	2014	Byrne B.;Gilmartin N.;Lakshmanan R.;O'Kennedy R. (2014) 'Antibodies, enzymes, and nucleic acid sensors for high throughput screening of microbes and toxins in food' In: High Throughput Screening for Food Safety Assessment: Biosensor Technologies, Hyperspectral Imaging and Practical Applications.
	2014	Gilmartin, N.;Byrne, B. (2014) 'Nanobiotechnology for the detection of food-borne pathogens' In: Microbial Food Safety And Preservation Techniques. Link
	2010	Arora, S., Pastorella, G., Byrne, B., Marsili, E. and O'Kennedy, R. (2010) 'Microbial cells and biosensing: a dual approach' In: Reviews in Pharmaceutical and Biomedical Analysis. In Press. : 0.
	2010	Byrne, B., Stack, E. and O'Kennedy, R. (2010) 'The application of biosensors for the sensitive detection of agricultural contaminants, pathogens and food-borne toxins' In: Food Biochemistry and Food Processing. In Press. : Wiley.
	2008	Byrne B., Carolan N. and O'Kennedy R. (2008) 'Biosensor-based technologies for the evaluation of quality' In: Paliyath G, Murr D.P., Handa A.K. and Lurie S. (Eds.). Post Harvest Biology and Technology of Fruits, Vegetables and Flowers. : Blackwell Publishing.

Conference Publication

	Year	Publication
	2013	Lakshmanan, R.S.;Efremov, V.;Cullen, S.;Byrne, B.;Killard, A.J. (2013) Progress in Biomedical Optics and Imaging - Proceedings of SPIE *Monitoring the effects of fibrinogen concentration on blood coagulation using quartz crystal microbalance (QCM) and its comparison with thromboelastography* Link

Peer Reviewed Journal

	Year	Publication
	2018	Efremov, V.;Lakshmanan, R.S.;Byrne, B.;Killard, A.J. (2018) 'Simple and convenient measurement of RBC deformability using QCM integrated with a novel model of cell viscoelasticity'. Sensors and Actuators, B: Chemical, 266 . Link
	2018	Fitzgerald S.;O'Reilly J.;Wilson E.;Joyce A.;Farrell R.;Kenny D.;Kay E.;Fitzgerald J.;Byrne B.;Kijanka G.;O'Kennedy R. (2018) 'Measurement of the IgM and IgG Autoantibody Immune Responses in Human Serum has High Predictive Value for the Presence of Colorectal Cancer'. Clinical Colorectal Cancer, .
	2017	Byrne, Barry;Barrett, Louise M. (2017) 'Lab-on-a-Chip Immunoassay Systems'. IMMUNOASSAYS: DEVELOPMENT, APPLICATIONS AND FUTURE TRENDS, :117-160.
	2016	O'Sullivan J.;Jenkins P.;Rawley O.;Gegenbauer K.;Chion A.;Lavin M.;Byrne B.;O'Kennedy R.;Preston R.;Brophy T.;O'Donnell J. (2016) 'Galectin-1 and galectin-3 constitute novel-binding partners for Factor VIII'. Arteriosclerosis, Thrombosis, and Vascular Biology, 36 (5):855-863.
	2016	O'Sullivan J.;Jenkins P.;Rawley O.;Gegenbauer K.;Chion A.;Lavin M.;Byrne B.;O'Kennedy R.;Preston R.;Brophy T.;O'Donnell J. (2016) 'Galectin-1 and galectin-3 constitute novel-binding partners for Factor VIII'. Arteriosclerosis, Thrombosis, and Vascular Biology, 36 (5):855-863.
	2016	Ralph, A;Somers, M;Cowman, J;Voisin, B;Hogan, E;Dunne, H;Dunne, E;Byrne, B;Kent, N;Ricco, AJ;Kenny, D;Wong, S (2016) 'Computational Tracking of Shear-Mediated Platelet Interactions with von Willebrand Factor'. Cardiovascular Engineering and Technology, 7 :389-405.
	2016	Cowman, J;Quinn, N;Geoghegan, S;Mullers, S;Oglesby, I;Byrne, B;Somers, M;Ralph, A;Voisin, B;Ricco, AJ;Molloy, EJ;Kenny, D (2016) 'Dynamic platelet function on von Willebrand factor is different in preterm neonates and full-term neonates: changes in neonatal platelet function'. Journal of Thrombosis and Haemostasis, 14 :2027-2035.
	2015	Cowman, J;Dunne, E;Oglesby, I;Byrne, B;Ralph, A;Voisin, B;Mullers, S;Ricco, AJ;Kenny, D (2015) 'Age-related changes in platelet function are more profound in women than in men'. Scientific Reports, 5 .
	2015	Gilmartin, Niamh;Byrne, Barry (2015) 'Nanobiotechnology for the Detection of Food-Borne Pathogens'. Microbial Food Safety And Preservation Techniques, :161-170.
	2015	Ravidà A.;Musante L.;Kreivi M.;Miinalainen I.;Byrne B.;Saraswat M.;Henry M.;Meleady P.;Clynes M.;Holthofer H. (2015) 'Glycosylation patterns of kidney proteins differ in rat diabetic nephropathy'. Kidney International, 87 (5):963-974.
	2015	Murphy, C;Stack, E;Krivelo, S;McPartlin, DA;Byrne, B;Greef, C;Lochhead, MJ;Husar, G;Devlin, S;Elliott, CT;O'Kennedy, RJ (2015) 'Detection of the cyanobacterial toxin, microcystin-LR, using a novel recombinant antibody-based optical-planar waveguide platform'. Biosensors and Bioelectronics, 67 :708-714.
	2015	Ravida, A;Musante, L;Kreivi, M;Miinalainen, I;Byrne, B;Saraswat, M;Henry, M;Meleady, P;Clynes, M;Holthofer, H (2015) 'Glycosylation patterns of kidney proteins differ in rat diabetic nephropathy'. Kidney International, 87 :963-974.
	2015	Ravida, A;Musante, L;Kreivi, M;Miinalainen, I;Byrne, B;Saraswat, M;Henry, M;Meleady, P;Clynes, M;Holthofer, H (2015) 'Glycosylation patterns of kidney proteins differ in rat diabetic nephropathy'. Kidney International, 87 :963-974.
	2014	Efremov, V.;Lakshmanan, R.S.;Byrne, B.;Cullen, S.M.;Killard, A.J. (2014) 'Modelling of blood component flexibility using quartz crystal microbalance'. Journal of Biorheology, 28 . Link
	2013	Musante, L.;Saraswat, M.;Ravidà, A.;Byrne, B.;Holthofer, H. (2013) 'Recovery of urinary nanovesicles from ultracentrifugation supernatants'. Nephrology Dialysis Transplantation, 28 . Link
	2013	McGrath, R.T.;Van Den Biggelaar, M.;Byrne, B.;O’Sullivan, J.M.;Rawley, O.;O’Kennedy, R.;Voorberg, J.;Preston, R.J.S.;O’Donnell, J.S. (2013) 'Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis'. Blood, 122 . Link
	2012	Musante L, Saraswat M, Duriez E, Byrne B, Ravida A, Domon B and Holthofer H. (2012) 'Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment'. 7 .
	2012	Musante, L.;Saraswat, M.;Duriez, E.;Byrne, B.;Ravidà, A.;Domon, B.;Holthofer, H. (2012) 'Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment'. PLoS ONE, 7 . Link
	2011	Whelehan, M., Byrne, B., O'Shea, D.G. and Marison, I.W. (2011) 'Successful application of capsular perstraction as a novel in-situ product recovery technique: removal and purification of geldanamycin from Streptomyces hygroscopicus cultures'. Process Biochemistry, In Review .
	2011	Welbeck K.;Leonard P.;Gilmartin N.;Byrne B.;Viguier C.;Arora S.;O'Kennedy R. (2011) 'Generation of an anti-NAGase single chain antibody and its application in a biosensor-based assay for the detection of NAGase in milk'. Journal of Immunological Methods, 364 (1-2):14-20.
	2011	Saraswat, M., Byrne, B., Ravidà, A., Musante, L. and Holthofer, H. (2011) 'Preparative purification of recombinant proteins of medicinal interest: Current and future trends. Annals of Medicine'. In Review .
	2010	McGrath R.;McKinnon T.;Byrne B.;O'Kennedy R.;Terraube V.;McRae E.;Preston R.;Laffan M.;O'Donnell J. (2010) 'Expression of terminal α2-6-linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13'. Blood, 115 (13):2666-2673.
	2010	McGrath, R.T., McKinnon, T.A., Byrne, B., O'Kennedy, R., Terraube, V., McRae, E., Preston, R.J., Laffan, M.A. and O'Donnell, J.S. (2010) 'Expression of terminal {alpha}2-6 linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13'. Blood, 115 :2666-2673.
	2010	Arora, Sushrut;Pastorella, Gabriele;Byrne, Barry;Marsili, Enrico;O'Kennedy, Richard (2010) 'Microbial Cells and Biosensing: A Dual Approach - Exploiting Antibodies and Microbial Cells as Analytical/Power Systems'. REVIEWS IN PHARMACEUTICAL & BIOMEDICAL ANALYSIS, :63-75.
	2010	O'Kennedy, R., Townsend, S., Donohoe, G.G., Leonard, P., Hearty, S. and Byrne, B. (2010) 'Speedy, Small, Sensitive and Specific - reality or myth for future analytical methods'. Analytical Letters, 43 :1630-1648.
	2010	Reeves, E.P.;Williamson, M.;Byrne, B.;Bergin, D.A.;Smith, S.G.J.;Greally, P.;O'Kennedy, R.;O'Neill, S.J.;McElvaney, N.G. (2010) 'IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis'. Journal of Immunology, 184 . Link
	2010	O'Kennedy R.;Townsend S.;Donohoe G.;Leonard P.;Hearty S.;Byrne B. (2010) 'Speedy, small, sensitive, and specific-reality or myth for future analytical methods'. Analytical Letters, 43 (10-11):1630-1648.
	2010	Hearty, S., Conroy, P., Ayyar, B.V., Byrne, B. and O'Kennedy, R. (2010) 'Surface Plasmon Resonance for Vaccine Design and Efficacy Studies: Recent Applications and Future Trends'. Expert Review of Vaccines, 9 :645-664.
	2010	Welbeck K, Leonard P, Gilmartin N, Byrne B, Viguier C, Arora S and O'Kennedy R (2010) 'Generation of an anti-NAGase single chain antibody and its application in a biosensor-based assay for the detection of NAGase in milk'. Journal of Immunological Methods, In Press .
	2010	Reeves, E.P., Williamson, M., Byrne, B., Bergin, D.A., Smith, S.G.J., Greally, P., O'Kennedy, R., O'Neill, S.J. and McElvaney, N.G. (2010) 'IL-8 Dictates Glycosaminoglycan Binding and Stability of IL-18 in Cystic Fibrosis'. Journal of Immunology, 184 :1642-1652.
	2009	Byrne B., Stack E., Gilmartin N. and O'Kennedy R. (2009) 'Antibody-based sensors: principles, problems and potential for detection of pathogens and associated toxins'. Sensors, 9 :4407-4445.
	2007	Byrne B., Donohoe G. and O'Kennedy R. (2007) 'Sialic acids: carbohydrate moieties that influence the biological and physical properties of biopharmaceutical proteins and living cells. '. 12 :319-326.
	2005	Carmody M., Murphy B., Byrne B., Power P., Rai D., Rawlings B. and Caffrey P. (2005) 'Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups. '. Journal of Biological Chemistry, 280 :34420-34426.
	2004	Carmody M., Byrne B., Murphy B., Breen C., Lynch S., Flood E., Finnan S. and Caffrey P. (2004) 'Analysis and manipulation of amphotericin biosynthetic genes by means of modified phage KC515 transduction techniques'. Gene, 343 :107-115.
	2003	Byrne B., Carmody M., Gibson E., Rawlings B. and Caffrey P. (2003) 'Biosynthesis of deoxyamphotericins and deoxyamphoteronolides by engineered strains of Streptomyces nodosus'. CHEMISTRY & BIOLOGY, 10 :1215-1224.

Review Articles

	Year	Publication
	2010	Hearty S.;Conroy P.;Ayyar B.;Byrne B.;O'Kennedy R. (2010) Surface plasmon resonance for vaccine design and efficacy studies: Recent applications and future trends. REV
	2009	Byrne B.;Stack E.;Gilmartin N.;O'Kennedy R. (2009) Antibody-based sensors: Principles, problems and potential for detection of pathogens and associated toxins. REV
	2007	Byrne, Barry;Donohoe, Gerard G.;O'Kennedy, Richard (2007) Sialic acids: carbohydrate moieties that influence the biological and physical properties of biopharmaceutical proteins and living cells. REV

Other Publication

	Year	Publication
		Doctor Barry Byrne
	2016	Egan, K;Alonso, AL;Jose, B;Gilmartin, N;McCluskey, P;Byrne, B;Ricco, A;Kenny, D (2016) A Novel Platelet Function Test Rapidly Detects Drug Effects in Patients with Cardiovascular Disease. LONDON:
	2013	Saraswat, M.;Musante, L.;Ravidá, A.;Shortt, B.;Byrne, B.;Holthofer, H. (2013) Preparative purification of recombinant proteins: Current status and future trends. Link
	2013	Efremov, V.;Killard, A.J.;Byrne, B.;Lakshmanan, R.S. (2013) The modelling of blood coagulation using the quartz crystal microbalance. Link
	2011	McGrath, R. T.;van den Biggelaar, M.;Byrne, B.;McRae, E.;Rawley, O.;O'Kennedy, R.;Voorberg, J.;O'Donnell, J. S. (2011) Platelet-derived von Willebrand factor glycosylation mediates resistance to ADAMTS13 proteolysis.
	2009	McGrath, Rachel Therese;McKinnon, Thomas A. J.;Byrne, Barry;O'Kennedy, Richard;Laffan, Michael;McRae, Emily;Preston, Roger J. S.;O'Donnell, James S. (2009) Terminal alpha 2-6 Linked Sialic Acid Expression On VWF Specifically Enhances Proteolysis by ADAMTS13.
	2009	Reeves, E. P.;Williamson, M.;Byrne, B.;O'Kennedy, R.;O'Neill, S. J.;Greally, P.;McElvaney, N. G. (2009) A TALE OF TWO CYTOKINES: INTERLEUKIN-8 AND INTERLEUKIN-18 COMPETITIVELY COMPETE FOR SURVIVAL WITHIN THE CYSTIC FIBROSIS LUNG.
	2004	Byrne B. (2004) The production of novel polyenes by engineering early and late stages of amphotericin biosynthesis. University College Dublin:

Other Journal

	Year	Publication
	2009	McGrath, R., McKinnon, T.A.J., Byrne, B., O'Kennedy, R., Laffan, M.A., McRae, E., Preston, R.J.S. and O'Donnell, J.S. (2009) 'Terminal alpha-2,6-linked sialic acid expression enhances VWF proteolysis by ADAMTS13' 114 :18-18.
	2009	Reeves, E.P., Williamson, M. Byrne, B., O'Kennedy, R., O'Neill, S.J., Greally, P. and McElvaney, N.G. (2009) 'A tale of two cytokines: interleukin-8 and interleukin-18 competitively compete for survival within the cystic fibrosis lung' 44 :257-257.